A dual-modal ROS generator based on multifunctional PDA–MnO₂@Ce6 nanozymes for synergistic chemo-photodynamic antibacterial therapy

Abstract

The rapid emergence of drug-resistant bacteria has attracted great attention to exploring advanced antibacterial methods. However, single-modal antibacterial therapy is difficult to eliminate drug-resistant bacteria completely due to its low...

Nanoarchitectonics of Bimetallic Cu-/Co-Doped Nitrogen–Carbon Nanozyme-Functionalized Hydrogel with NIR-Responsive Phototherapy for Synergistic Mitigation of Drug-Resistant Bacterial Infections

“…Various metallic nanomaterials including monometallic Co NPs, Cu NPs, CoS NSs, chitosan (CS)-Cu-GA NCs, MnO 2 @Ce 6 , ICG@hMnO x , bimetallic Cu 2 O-SnO 2 , MoS 2 /CoS 2 NFs, FeCo@PDA NPs, Cu 1.5 Mn 1.5 O 4 cage-like frame (CF) NSs, cobalt copper glycerate hollow nanospheres (CCG-HNSs), and trimetallic Mo/Fe@CuO 2 have been reported. In this work, bimetallic CuCo/NC exhibits POD-like, OXD-like, photothermal, and photodynamic activities, the MIC value in the CuCo/NC+H 2 O 2 system is 40 μg mL –1 , and the sterilization rate of CuCo/NC-HG+H 2 O 2 +NIR system against MRSA and Amp r E. coli is 99.79 and 99.70%, respectively.…”

Advanced nanozymes possess peroxidase-like catalytic activities in biomedical and antibacterial fields: review and progress

“…To mitigate the issues of insufficient specificity and reduced catalytic efficiency caused by substrate competition inhibition, Yuan et al synthesized octahedral, rod-shaped, and cubic CeO 2 nanozymes, each with their respective dominant crystal facets: Ce 7c (111), Ce 6c (110), and Ce 6c (100) (Fig. 5).…”

“…5). 41 The coordination of seven oxygen atoms with cerium atoms on the Ce 7c (111) facet allows it to form monodentate peroxides upon binding with H 2 O 2 , endowing it with haloperoxidase-like activity (one of the pathways for the CeO 2 activation of H 2 O 2 , specifically the peroxide pathway). Another activation pathway for CeO 2 is the free radical pathway, activated by the formation of bidentate peroxides with H 2 O 2 on the Ce 6c (110) and Ce 6c (100) facets.…”

“…The authors have successfully loaded the photosensitizer Ce6 onto PDA-MnO 2 . 111 Under the influence of singlet oxygen generated through photodynamic processes, and • OH produced by POD, the anti- bacterial efficacy is significantly enhanced compared to the solitary CDT method, achieving near 100% elimination of S. aureus and E. coli. In antibacterial therapies reliant on external light sources, the majority of utilized light belongs to the NIR spectrum due to its superior penetration capabilities.…”

Recent design strategies for boosting chemodynamic therapy of bacterial infections

“…[57] By combining CDT and PDT for sterilization, the limitations of PDT can be overcome while improving the sterilization effectiveness of CDT, which promotes the use of CDT in the antimicrobial field. [58] PDA-MnO 2 @Ce6/liposome (PMCL) Ce6 Self-supplying oxygen to enhance 1 O 2 generation [59] PLNP-PS Cyanine probe (PS) Activable fluorescence imaging photodynamic therapy [61] ZIF-ICG@ZIF-GOX@MPN Indocyanine green (ICG) Inducing 1 O 2 generation under near-infrared light irradiation [21] FeP@PL:ZnPc (COOH) 8 ZnPc(COOH) 8 GSH depletion, inducing ROS generation [62] F I G U R E  CDT-PDT combined antibacterial therapy. A TPCI/MMT NPs for CDT-PDT.…”