A dual flip angle 3D bSSFP magnetization transfer‐like method to differentiate between recent and old myocardial infarction

Germain, Philippe; Ghannudi, Soraya El; Labani, Aïssam; Jeung, Mi Young; Gangi, Afshin; Ohlmann, Patrick; Roy, Catherine

doi:10.1002/jmri.25821

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Weber et al assessed MT effects in MI based on 2 sets of balanced SSFP (bSSFP) images with different levels of RF power deposition, which are achieved by varying the RF excitation pulse length while keeping the flip angle constant. In contrast, dual‐flip angle bSSFP images have also been used to exploit MT effects in MI, and the normalized signal differences between those bSSFP images were found to be strongly correlated with standard LGE measures …”

Section: Introductionmentioning

confidence: 99%

Non‐contrast myocardial infarct scar assessment using a hybrid native T₁ and magnetization transfer imaging sequence at 1.5T

Duan

Zhu

Jang

et al. 2018

Magnetic Resonance in Med

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Purpose To develop a gadolinium‐free cardiac MR technique that simultaneously exploits native T1 and magnetization transfer (MT) contrast for the imaging of myocardial infarction. Methods A novel hybrid T one and magnetization transfer (HYTOM) method was developed based on the modified look‐locker inversion recovery (MOLLI) sequence, with a train of MT‐prep pulses placed before the balanced SSFP (bSSFP) readout pulses. Numerical simulations, based on Bloch‐McConnell equations, were performed to investigate the effects of MT induced by (1) the bSSFP readout pulses, and (2) the MT‐prep pulses, on the measured, “apparent,” native T1 values. The HYTOM method was then tested on 8 healthy adult subjects, 6 patients, and a swine with prior myocardial infarction (MI). The resulting imaging contrast between normal myocardium and infarcted tissues was compared with that of MOLLI. Late gadolinium enhancement (LGE) images were also obtained for infarct assessment in patients and swine. Results Numerical simulation and in vivo studies in healthy volunteers demonstrated that MT effects, resulting from on‐resonance bSSFP excitation pulses and off‐resonance MT‐prep pulses, reduce the measured T1 in both MOLLI and HTYOM. In vivo studies in patients and swine showed that the HYTOM sequence can identify locations of MI, as seen on LGE. Furthermore, the HYTOM method yields higher myocardium‐to‐scar contrast than MOLLI (contrast‐to‐noise ratio: 7.33 ± 1.67 vs. 3.77 ± 0.66, P < 0.01). Conclusion The proposed HYTOM method simultaneously exploits native T1 and MT contrast and significantly boosts the imaging contrast for myocardial infarction.

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Section: Introductionmentioning

confidence: 99%

Non‐contrast myocardial infarct scar assessment using a hybrid native T₁ and magnetization transfer imaging sequence at 1.5T

Duan

Zhu

Jang

et al. 2018

Magnetic Resonance in Med

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“…However, breath-holding can be difficult in sick patients, where the length of breath-hold may limit the spatial resolution and different breath-hold positions may lead to misregistration artefacts between slices. Germain et al has recently proposed a diaphragmatic navigated free-breathing 3D on-resonance MT approach [ 19 ], where they show some agreement between LGE enhancement and reduced MT effects in patients with acute or recent MI. However, partial volume effects and likely residual motion seem to have caused significant intra- and intersubject variability.…”

Section: Introductionmentioning

confidence: 99%

Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization

López

Neji

Mukherjee

et al. 2020

Magn Reson Mater Phy

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Objective To develop a three-dimensional (3D) high-resolution free-breathing magnetization transfer ratio (MTR) sequence for contrast-free assessment of myocardial infarct and coronary vein anatomy. Materials and methods Two datasets with and without off-resonance magnetization transfer preparation were sequentially acquired to compute MTR. 2D image navigators enabled beat-to-beat translational and bin-to-bin non-rigid motion correction. Two different imaging sequences were explored. MTR scar localization was compared against 3D late gadolinium enhancement (LGE) in a porcine model of myocardial infarction. MTR variability across the left ventricle and vessel sharpness in the coronary veins were evaluated in healthy human subjects. Results A decrease in MTR was observed in areas with LGE in all pigs (non-infarct: 25.1 ± 1.7% vs infarct: 16.8 ± 1.9%). The average infarct volume overlap on MTR and LGE was 62.5 ± 19.2%. In humans, mean MTR in myocardium was between 37 and 40%. Spatial variability was between 15 and 20% of the mean value. 3D whole heart MT-prepared datasets enabled coronary vein visualization with up to 8% improved vessel sharpness for non-rigid compared to translational motion correction. Discussion MTR and LGE showed agreement in infarct detection and localization in a swine model. Free-breathing 3D MTR maps are feasible in humans but high spatial variability was observed. Further clinical studies are warranted.

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Review of Myocardial Ischemia, Scar, and Viability Estimation with Molecular Magnetic Resonance Imaging

Sillanmäki,

Hartikainen,

Ylä-Herttuala

2024

Biomedicines

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Background: Cardiovascular diseases, particularly myocardial ischemia from coronary artery obstruction, remain a leading cause of global morbidity. This review explores cardiac molecular magnetic resonance imaging (mMRI) and other molecular imaging techniques for the evaluation of myocardial ischemia, scarring, and viability. Results and findings: mMRI imaging methods provide detailed information on myocardial ischemia, edema, and scar tissue using techniques like cine imaging, T1 and T2 mapping, and gadolinium-based contrast agents. These methods enable the precise assessment of the myocardial tissue properties, crucial in diagnosing and treating cardiovascular diseases. Advanced techniques, such as the T1ρ and RAFFn methods, might provide enhanced contrast and sensitivity for the detection of myocardial scarring without contrast agents. Molecular probes, including gadolinium-based and protein-targeted contrast agents, improve the detection of molecular changes, facilitating early diagnosis and personalized treatment. Integrating MRI with positron emission tomography (PET) combines the high spatial and temporal resolution with molecular and functional imaging. Conclusion: Recent advancements in mMRI and molecular imaging have changed the evaluation of myocardial ischemia, scarring, and viability. Despite significant progress, extensive research is needed to validate these techniques clinically and further develop imaging methods for better diagnostic and prognostic outcomes.

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A dual flip angle 3D bSSFP magnetization transfer‐like method to differentiate between recent and old myocardial infarction

Abstract: 3 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:798-808.

Cited by 3 publications

References 37 publications

Non‐contrast myocardial infarct scar assessment using a hybrid native T₁ and magnetization transfer imaging sequence at 1.5T

Non‐contrast myocardial infarct scar assessment using a hybrid native T₁ and magnetization transfer imaging sequence at 1.5T

Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization

Review of Myocardial Ischemia, Scar, and Viability Estimation with Molecular Magnetic Resonance Imaging

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A dual flip angle 3D bSSFP magnetization transfer‐like method to differentiate between recent and old myocardial infarction

Abstract: 3 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:798-808.

Cited by 3 publications

References 37 publications

Non‐contrast myocardial infarct scar assessment using a hybrid native T1 and magnetization transfer imaging sequence at 1.5T

Non‐contrast myocardial infarct scar assessment using a hybrid native T1 and magnetization transfer imaging sequence at 1.5T

Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization

Review of Myocardial Ischemia, Scar, and Viability Estimation with Molecular Magnetic Resonance Imaging

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Product

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Non‐contrast myocardial infarct scar assessment using a hybrid native T₁ and magnetization transfer imaging sequence at 1.5T

Non‐contrast myocardial infarct scar assessment using a hybrid native T₁ and magnetization transfer imaging sequence at 1.5T