A dual-emission and large Stokes shift fluorescence probe for real-time discrimination of ROS/RNS and imaging in live cells

Guo, Ting; Cui, Lei; Shen, Jiaoning; Wang, Rui; Zhu, Weiping; Xu, Yufang; Qian, Xuhong

doi:10.1039/c3cc38471c

Cited by 102 publications

(43 citation statements)

References 43 publications

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“…To address the challenges inherent in the in vivo monitoring of HOCl, fluorescent and/or colorimetric indicators based on unique reaction mechanisms have been recently reported by several research groups. These indicator mechanisms include p -methoxyphenol oxidation to p -benzoquinones, 18–23 oxime oxidation to aldehydes, 24–29 the chlorination of thioesters and amides, 30–40 p -aminophenol analog oxidation, 4,41–44 thioether to sulfonate and selenide to selenoxide transformations, 5,45–59 the cleavage of carbon-carbon double bonds, 2,60–62 and oxidative processes in metal complexes. 7,63–67 This review classifies probes for HOCl based on the seven different detection mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Recent progress in chromogenic and fluorogenic chemosensors for hypochlorous acid

Yue

Huo

Yin

et al. 2016

Analyst

168

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Due to the biological and industrial importance of hypochlorous acid, the development of optical probes for HOCl has been an active research area. Hypochlorous acid and hypochlorite can oxidize electron-rich analytes with accompanying changes in molecular sensor spectroscopic profiles. Probes for such processes may monitor HOCl levels in the environment or in an organism and via bio-labeling or bioimaging techniques. This review summarizes recent developments in the area of chromogenic and fluorogenic chemosensors for HOCl.

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Section: Introductionmentioning

confidence: 99%

Recent progress in chromogenic and fluorogenic chemosensors for hypochlorous acid

Yue

Huo

Yin

et al. 2016

Analyst

168

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“…1,2 Fluorescent probes with high sensitivity and selectivity have become a powerful non-destructive tool for real-time monitoring. 3,4 Fluorescent probes can sensitively detect toxic metal ions in the environment. Moreover, the emergence of metal ion imaging to examine changes in the intracellular distribution and the mobilization upon physiological or pathological stimuli is expected within the decade.…”

Section: Studies Have Indicated That Mgmentioning

confidence: 99%

Solvent Effect on the Fluorescence Response of Hydroxycoumarin Bearing a Dipicolylamine Binding Site to Metal Ions

et al. 2014

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The fluorescence behavior of a probe dpa-HC, which has a coumarin derivative that acts as a fluorophore and a dipicolylamine (DPA) unit that functions as a metal ion-recognition site, was investigated with various metal ions in aqueous and several non-aqueous solvents. In aqueous solution, the fluorescence of dpa-HC was enhanced by Zn 2+ and Cd 2+ , but was quenched by other metal ions. On the other hand, in an acetonitrile solution, only Mg 2+ enhanced the fluorescence, and the addition of a small amount of water quenched this fluorescence. This dramatic selectivity change is explained by stabilization of a metal-dpa-HC complex due to acetonitrile coordination and ON-OFF switching of the intramolecular photoinduced electron transfer (PET) from the nitrogen lone pair of DPA to the coumarin derivative. Scheme 1 Synthesis of 8-(2,2′-dipicolylaminomethyl)-7-hydroxycoumarin (dpa-HC). Keywords

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“…In another probe (33) for hypochlorite [14], a deacylation is trigger by the recognition event (Fig. 10).…”

Section: Probe Design Via Modification Of -Nh 2 At C-3mentioning

confidence: 99%

Naphthalimides for labeling and sensing applications

Jia

et al. 2014

Pure and Applied Chemistry

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Naphthalimide has now become a class of most popular fluorophores for probe design, along with coumarin, fluorescein, rhodamine, BODIPY and cyanine. This account aims at the first-year graduate students as the primary audience and showcases the versatile design principles applicable to the naphthalimide fluorophore when designing a probe or label, with focused examples from the Qian research laboratory. We also provide a general synthetic scheme to naphthalimides of various substitution patterns.

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A dual-emission and large Stokes shift fluorescence probe for real-time discrimination of ROS/RNS and imaging in live cells

Cited by 102 publications

References 43 publications

Recent progress in chromogenic and fluorogenic chemosensors for hypochlorous acid

Recent progress in chromogenic and fluorogenic chemosensors for hypochlorous acid

Solvent Effect on the Fluorescence Response of Hydroxycoumarin Bearing a Dipicolylamine Binding Site to Metal Ions

Naphthalimides for labeling and sensing applications

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