A dual-action chitosan-based nanogel system of triclosan and flurbiprofen for localised treatment of periodontitis

Aminu, Nafiu; Chan, Siok-Yee; Yam, Mun-Fei; Toh, Seok-Ming

doi:10.1016/j.ijpharm.2019.118659

Cited by 74 publications

(36 citation statements)

References 48 publications

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“…Periodontitis is a chronic inflammatory disease of the periodontium caused by the bacteria Porphyromonas gingivalis and Streptococcus strains that accumulate in periodontal pockets, leading to the loss of teeth ( Aminu et al, 2013 , Aminu et al, 2017 , Van Dyke and Sima, 2020 ). Treatment of periodontitis using systemic antimicrobial drugs is known to cause undesirable side effects; therefore, it would be interesting to explore the use of appropriate drug delivery systems for local antimicrobial drug delivery to the periodontal pocket ( Aminu et al, 2019 ). Concerning with the local drug delivery system, not only the ease in injection, release of the drug in a controlled manner but also the biodegradability, biocompatibility and non-irritating to the tissue should be considered.…”

Section: Introductionmentioning

confidence: 99%

Doxycycline hyclate-loaded in situ forming gels composed from bleached shellac, Ethocel, and Eudragit RS for periodontal pocket delivery

Senarat

Lwin

Mahadlek

et al. 2021

Saudi Pharmaceutical Journal

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Polymeric material plays an important role as a matrix former in the modulation of drug release of antimicrobial-loaded in situ forming gel (ISG) for efficient periodontitis treatment. This study was conducted to compare three polymers, namely bleached shellac (BS), Ethocel (EC) and Eudragit RS (ERS), as matrix formers of doxycycline hyclate (DH)-loaded solvent exchange-induced ISG. All prepared ISGs, except 25% EC ISG, exhibited the Newtonian flow behaviour. Transformation from solution into matrix-like was achieved rapidly within 5 min. Increasing the amount of these polymers extended the release of DH. DH-loaded EC and ERS ISG systems exhibited high antimicrobial activity, and all ISGs were effective in inhibiting the growth of Staphylococcus aureus , Escherichia coli , Streptococcus mutans , Porphyromonas gingivalis and Candida albicans . By comparison, the DH-loaded ERS ISG, through the solvent exchange mechanism, was found to be ease in injection with low viscosity and sustained the release with higher concentration, meanwhile, it also exhibited interesting in vitro degradability and antimicrobial activities. Therefore, the DH-loaded ERS ISG exhibited a potential use for localized periodontal drug delivery system for the treatment periodontitis.

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Section: Introductionmentioning

confidence: 99%

Doxycycline hyclate-loaded in situ forming gels composed from bleached shellac, Ethocel, and Eudragit RS for periodontal pocket delivery

Senarat

Lwin

Mahadlek

et al. 2021

Saudi Pharmaceutical Journal

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“…Polymeric nanoparticles of PCL encapsulating the anti-microbial agent triclosan were synthesized by Aminu et al These nanoparticles were further loaded into a chitosan nanogel containing the non-steroidal anti-inflammatory drug flurbiprofen. An in vivo study in rats demonstrated the dual-activity of the nano-formulation providing resolution of gingival inflammation and reduction of accumulated plaque [129].…”

Section: Polymeric Nanoparticles For Drug Delivery and Immunomodulationmentioning

confidence: 99%

Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications

et al. 2021

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The risk of secondary bacterial infections resulting from dental procedures has driven the design of antimicrobial and antifouling dental materials to curb pathogenic microbial growth, biofilm formation and subsequent oral and dental diseases. Studies have investigated approaches based primarily on contact-killing or release-killing materials. These materials are designed for addition into dental resins, adhesives and fillings or as immobilized coatings on tooth surfaces, titanium implants and dental prosthetics. This review discusses the recent developments in the different classes of biomaterials for antimicrobial and antifouling dental applications: polymeric drug-releasing materials, polymeric and metallic nanoparticles, polymeric biocides and antimicrobial peptides. With modifications to improve cytotoxicity and mechanical properties, contact-killing and anti-adhesion materials show potential for incorporation into dental materials for long-term clinical use as opposed to short-lived antimicrobial release-based coatings. However, extended durations of biocompatibility testing, and adjustment of essential biomaterial features to enhance material longevity in the oral cavity require further investigations to confirm suitability and safety of these materials in the clinical setting. The continuous exposure of dental restorative and regenerative materials to pathogenic microbes necessitates the implementation of antimicrobial and antifouling materials to either replace antibiotics or improve its rational use, especially in the day and age of the ever-increasing problem of antimicrobial resistance.

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“…Anti-inflammatory and antimicrobial CS-based nanogels using triclosan and flurbiprofen were obtained. Flurbiprofen was directly loaded into the nanogel, and Triclosan was prepared as nanoparticles using poly(ε-caprolactone) (PCL) [ 24 ]. The two systems showed a sustained and rapid in vitro release of drugs.…”

Section: Polymer–drug Systemsmentioning

confidence: 99%

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

et al. 2021

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Periodontal diseases are worldwide health problems that negatively affect the lifestyle of many people. The long-term effect of the classical treatments, including the mechanical removal of bacterial plaque, is not effective enough, causing the scientific world to find other alternatives. Polymer–drug systems, which have different forms of presentation, chosen depending on the nature of the disease, the mode of administration, the type of polymer used, etc., have become very promising. Hydrogels, for example (in the form of films, micro-/nanoparticles, implants, inserts, etc.), contain the drug included, encapsulated, or adsorbed on the surface. Biologically active compounds can also be associated directly with the polymer chains by covalent or ionic binding (polymer–drug conjugates). Not just any polymer can be used as a support for drug combination due to the constraints imposed by the fact that the system works inside the body. Biopolymers, especially polysaccharides and their derivatives and to a lesser extent proteins, are preferred for this purpose. This paper aims to review in detail the biopolymer–drug systems that have emerged in the last decade as alternatives to the classical treatment of periodontal disease.

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A dual-action chitosan-based nanogel system of triclosan and flurbiprofen for localised treatment of periodontitis

Cited by 74 publications

References 48 publications

Doxycycline hyclate-loaded in situ forming gels composed from bleached shellac, Ethocel, and Eudragit RS for periodontal pocket delivery

Doxycycline hyclate-loaded in situ forming gels composed from bleached shellac, Ethocel, and Eudragit RS for periodontal pocket delivery

Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

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