A Drug‐Free Tumor Therapy Strategy: Cancer‐Cell‐Targeting Calcification

Zhao, Ruibo; Wang, Ben; Yang, Xinyan; Xiao, Yun; Wang, Xiaoyu; Shao, Changyu; Tang, Ruikang

doi:10.1002/anie.201601364

Cited by 102 publications

(72 citation statements)

References 44 publications

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“…Meanwhile, scientists investigated a complete calcification‐based tumour therapy. In the calcification treatment, the nuclei of tumour cells become agglutinated and abnormal, indicating that the CaP mineral coat promotes cell death (Figure C,D). It should be noted that both folate and calcium are essential ingredients in human metabolism and exhibit drug‐free features, which is a primary advantage of CCTC.…”

Section: Biological Strategy For Organism Modificationmentioning

confidence: 99%

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Biomineralization: From Material Tactics to Biological Strategy

et al. 2017

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Biomineralization is an important tactic by which biological organisms produce hierarchically structured minerals with marvellous functions. Biomineralization studies typically focus on the mediation function of organic matrices on inorganic minerals, which helps scientists to design and synthesize bioinspired functional materials. However, the presence of inorganic minerals may also alter the native behaviours of organic matrices and even biological organisms. This progress report discusses the latest achievements relating to biomineralization mechanisms, the manufacturing of biomimetic materials and relevant applications in biological and biomedical fields. In particular, biomineralized vaccines and algae with improved thermostability and photosynthesis, respectively, demonstrate that biomineralization is a strategy for organism evolution via the rational design of organism-material complexes. The successful modification of biological systems using materials is based on the regulatory effect of inorganic materials on organic organisms, which is another aspect of biomineralization control. Unlike previous studies, this study integrates materials and biological science to achieve a more comprehensive view of the mechanisms and applications of biomineralization.

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Section: Biological Strategy For Organism Modificationmentioning

confidence: 99%

Section: Biological Strategy For Organism Modificationmentioning

confidence: 99%

Biomineralization: From Material Tactics to Biological Strategy

et al. 2017

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“…For example, a report showed that folate‐induced calcium phosphate formation at the surface of HeLa cells (and cancerous cells in vivo) ruptured the integrity of cell membranes and induced cell death. [ 28 ] This in situ mineralization approach might be applied to microbial cells, which have tougher cell walls, for the formation of self‐repairing shells.…”

Section: Dynamic Shellsmentioning

confidence: 99%

Single‐Cell Nanoencapsulation: From Passive to Active Shells

et al. 2020

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Single‐cell nanoencapsulation is an emerging field in cell‐surface engineering, emphasizing the protection of living cells against external harmful stresses in vitro and in vivo. Inspired by the cryptobiotic state found in nature, cell‐in‐shell structures are formed, which are called artificial spores and which show suppression or retardation in cell growth and division and enhanced cell survival under harsh conditions. The property requirements of the shells suggested for realization of artificial spores, such as durability, permselectivity, degradability, and functionalizability, are demonstrated with various cytocompatible materials and processes. The first‐generation shells in single‐cell nanoencapsulation are passive in the operation mode, and do not biochemically regulate the cellular metabolism or activities. Recent advances indicate that the field has shifted further toward the formation of active shells. Such shells are intimately involved in the regulation and manipulation of biological processes. Not only endowing the cells with new properties that they do not possess in their native forms, active shells also regulate cellular metabolism and/or rewire biological pathways. Recent developments in shell formation for microbial and mammalian cells are discussed and an outlook on the field is given.

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“…In this approach, certain in situ macromolecular systems are introduced or formed in situ inside the cell or subcellular compartments to lead to cell death either by physical damage or by inhibition of the metabolic function. Self-assembly, aggregation, polymerization, and biomineralization inside the cancer cells are emerging examples that could tackle cancer cells efficiently [68]. In the drug-free approach, the anticancer activity turns on once the macromolecular system interacts with the targeted cancer cell component while being inactive in their molecular state, thus inducing fewer side effects both in vivo and in vitro.…”

Section: Mitochondria-targeted Drug-free Agentsmentioning

confidence: 99%

Recent Progress in Mitochondria-Targeted Drug and Drug-Free Agents for Cancer Therapy

Jeena

Kim

Jin

et al. 2019

Cancers

106

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The mitochondrion is a dynamic eukaryotic organelle that controls lethal and vital functions of the cell. Being a critical center of metabolic activities and involved in many diseases, mitochondria have been attracting attention as a potential target for therapeutics, especially for cancer treatment. Structural and functional differences between healthy and cancerous mitochondria, such as membrane potential, respiratory rate, energy production pathway, and gene mutations, could be employed for the design of selective targeting systems for cancer mitochondria. A number of mitochondria-targeting compounds, including mitochondria-directed conventional drugs, mitochondrial proteins/metabolism-inhibiting agents, and mitochondria-targeted photosensitizers, have been discussed. Recently, certain drug-free approaches have been introduced as an alternative to induce selective cancer mitochondria dysfunction, such as intramitochondrial aggregation, self-assembly, and biomineralization. In this review, we discuss the recent progress in mitochondria-targeted cancer therapy from the conventional approach of drug/cytotoxic agent conjugates to advanced drug-free approaches.In healthy cells, mitochondria execute a controlled regulation of multiple functions to maintain the cellular growth-death cycle. However, in the case of tumor cells, to meet the higher metabolic demand of rapidly proliferating cells, dysregulation of mitochondrial metabolism occurs [14,15]. The difference between cancer cell mitochondria and normal cells includes several functional alterations, such as mutation of mtDNA that lead to OXPHOS (oxidative phosphorylation) inhibition and thus deficient respiration and ATP generation, mutation of mtDNA-encoded mitochondrial enzymes, such as SDH (succinate dehydrogenase), IDH1 (isocitrate dehydrogenase 1), IDH2 (isocitrate dehydrogenase 2) [16], and structural differences, such as higher membrane potential of cancer cell mitochondria and higher basicity inside the mitochondrial lumen. The evasion of cell death or inhibition of mitochondria-mediated apoptosis is a hallmark for cancer. Mitochondria generate ROS, which is necessary for signaling under normal conditions. However, when apoptosis is inhibited in the case of cancer, ROS contributes to the neoplastic transformation. Furthermore, for supporting tumor cell survival under harsh tumorigenic conditions, such as nutrient depletion and hypoxia, mitochondria provide flexibility in several pathways either by up-or downregulation [17]. This altered mitochondrial metabolism of cancer cells compared with that of their normal counterparts is advantageous for the selective targeting of cancer mitochondria in therapeutics, which focuses on the cancer mitochondria specific features [18]. Directing the therapeutic agent to the mitochondria is an efficient way of eliminating cancer cells because the designed drug molecules could act at the central point of the cell, and therefore, engineering mitochondrial-targeted therapeutic agents have gained much interest in cancer thera...

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A Drug‐Free Tumor Therapy Strategy: Cancer‐Cell‐Targeting Calcification

Cited by 102 publications

References 44 publications

Biomineralization: From Material Tactics to Biological Strategy

Biomineralization: From Material Tactics to Biological Strategy

Single‐Cell Nanoencapsulation: From Passive to Active Shells

Recent Progress in Mitochondria-Targeted Drug and Drug-Free Agents for Cancer Therapy

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