A dramatic case of acne fulminans responding to adalimumab

Miguel, Diana; Tittelbach, Jörg; Elsner, Peter

doi:10.1111/ddg.13842

Cited by 14 publications

(46 citation statements)

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“…However, in some patients isotretinoin has been considered a triggering factor of AF. TNF-alpha inhibitors have been also suggested as a treatment option in AF [9].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Successful Treatment of Coexistent Acne Fulminans and Severe Hidradenitis Suppurativa with Adalimumab

Kontochristopoulos

Agiasofitou

Platsidaki

et al. 2021

Skin Appendage Disord

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The coexistence of hidradenitis suppurativa (HS) and acne fulminans (AF) has only recently been reported in the literature. We present a case of a 17-year-old man who presented with a 2 years history of severe acne and HS. He was initially started on oral clindamycin and rifampicin for 3 months with no clinical improvement. Acne lesions became worse with the presence of nodules and necrotic ulcers, while weight loss, low-grade fever, back and knee pain, and psychological distress were noted. We prescribed adalimumab in its standard dosing regimen. Remission of AF was achieved in 3 months, whereas adalimumab has not been as effective in treating the HS lesions. Its dosage was increased to 80 mg weekly and more than 80% clinical improvement of HS lesions was obtained in 2 months. The patient maintained on this dosage till this day and efficacy is sustained. TNF-α inhibitors are considered an effective option in the treatment of HS, while it has been also suggested as a treatment option in AF. Our patient was successfully treated with adalimumab. Since the coexistence of HS and AF has a devastating emotional effect on the patient, there is an urgent need to implement therapeutic approaches.

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“…However, in some patients isotretinoin has been considered a triggering factor of AF. TNF-alpha inhibitors have been also suggested as a treatment option in AF [9].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Successful Treatment of Coexistent Acne Fulminans and Severe Hidradenitis Suppurativa with Adalimumab

Kontochristopoulos

Agiasofitou

Platsidaki

et al. 2021

Skin Appendage Disord

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“…ADA, an anti-TNF-α monoclonal antibody, has been approved for the treatment of multiple pediatric conditions [8]. Moreover, the efficacy of off-label therapy with ADA in the treatment of several dermatological disorders, including pyoderma gangrenosum, and IIAF has been reported [9][10][11]. In a previous study, it has been demonstrated that mTOR gene expression was reduced by ADA, suggesting the tight relationship between mTOR pathway and TNF-α [12].…”

Section: Discussionmentioning

confidence: 99%

Adalimumab in the Management of Isotretinoin-Induced Acne Fulminans: Report of a Case

Marasca

Fabbrocini

Abategiovanni

et al. 2021

Skin Appendage Disord

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Acne fulminans (AF) is a rare, acute, and severe form of acne vulgaris often associated with systemic symptoms. Its treatment is challenging and controversial. We report a case of isotretinoin-induced AF (IIAF) in a 12-year-old boy resistant to traditional therapies (oral steroids and isotretinoin). The patient was successfully treated with adalimumab that can be considered an effective off-label option in the treatment of resistant IIAF in children.

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“…There are a few cases reported in the literature on the effects of biologic agents like adalimumab, etanercept, and infliximab in the treatment of AF [50,58,69]. Improvement of AF with biological treatment leads to speculation about whether or not AF may represent an atypical presentation of hidradenitis suppurativa.…”

Section: Dermatology Online Journal || Case Reportmentioning

confidence: 99%

Acne fulminans induced by a low dose isotretinoin: case report and review of the literature

Fakih¹,

Goens²,

Grozdev³

et al. 2020

Dermatology Online Journal

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A dramatic case of acne fulminans responding to adalimumab

Cited by 14 publications

References 0 publications

Successful Treatment of Coexistent Acne Fulminans and Severe Hidradenitis Suppurativa with Adalimumab

Successful Treatment of Coexistent Acne Fulminans and Severe Hidradenitis Suppurativa with Adalimumab

Adalimumab in the Management of Isotretinoin-Induced Acne Fulminans: Report of a Case

Acne fulminans induced by a low dose isotretinoin: case report and review of the literature

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