A Dramatic Accumulation of Glycogen in the Brown Adipose Tissue of Rats Following Recovery from Cold Exposure

Farkas, Viktória; Kelényi, G; Sándor, Attila

doi:10.1006/abbi.1999.1157

Cited by 30 publications

(39 citation statements)

References 27 publications

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“…However, in the reacclimation period, the phosphorylation of Akt and GSK-3 increased markedly, indicating that enhanced insulin signaling during reacclimation is not restricted to BAT. This finding supports our earlier proposal concerning a "post-cold glycogen replenishment" in muscle (6).…”

Section: Discussionsupporting

confidence: 93%

“…1-3) mostly referred to FA metabolism. As for glucose metabolism, we reported previously a marked accumulation of glycogen in BAT of rats during reacclimation (6). Here, further investigations are presented on the mechanism of this effect.…”

Section: Changes In Signal Transduction and Other Conditions Lead To mentioning

confidence: 66%

“…The second part of this work was devoted to an examination of glucose metabolism, namely, the mechanism of glycogen accumulation in BAT and muscle during reacclimation (6). The endocrine and enzymatic changes under this condition, as well as glucose metabolism, especially the insulin signaling cascade, were investigated.…”

Section: Discussionmentioning

confidence: 99%

“…ACC and CitLy activities were measured spectrophotometrically as reported previously (13,14). Glycogen content was measured as described previously (6).…”

Section: Fatty Acid and Glycogen Synthesis In Bat And Watmentioning

confidence: 99%

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Cooperation between BAT and WAT of rats in thermogenesis in response to cold, and the mechanism of glycogen accumulation in BAT during reacclimation

Jakus

Sándor

Janáky

et al. 2008

Journal of Lipid Research

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Rats were exposed to cold and then reacclimated at neutral temperature. Changes related to fatty acid and glucose metabolism in brown and white adipose tissues (BAT and WAT) and in muscle were then examined. Of the many proteins involved in the metabolic response, two lipogenic enzymes, acetyl-coenzyme A carboxylase (ACC) and ATPcitrate lyase, were found to play a pervasive role and studied in detail. Expression of the total and phosphorylated forms of both lipogenic enzymes in response to cold increased in BAT but decreased in WAT. Importantly, in BAT, only the phosphorylation of the ACC1 isoenzyme was enhanced, whereas that of ACC2 remained unchanged. The activities of these enzymes and the in vivo rate of FFA synthesis together suggested that WAT supplies BAT with FFA and glucose by decreasing its own synthetic activity. Furthermore, cold increased the glucose uptake of BAT by stimulating the expression of components of the insulin signaling cascade, as observed by the enhanced expression and phosphorylation of Akt and GSK-3. In muscle, these changes were observed only during reacclimation, when serum insulin also increased. Such changes may be responsible for the extreme glycogen accumulation in the BAT of rats reacclimated from cold.-Jakus, P. B., A. Sandor, T. Janaky, and V. Farkas. Cooperation between BAT and WAT of rats in thermogenesis in response to cold, and the mechanism of glycogen accumulation in BAT during reacclimation. J. Lipid Res. 2008. 49: 332-339.

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Section: Discussionsupporting

confidence: 93%

Section: Changes In Signal Transduction and Other Conditions Lead To mentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

“…ACC and CitLy activities were measured spectrophotometrically as reported previously (13,14). Glycogen content was measured as described previously (6).…”

Section: Fatty Acid and Glycogen Synthesis In Bat And Watmentioning

confidence: 99%

See 2 more Smart Citations

Cooperation between BAT and WAT of rats in thermogenesis in response to cold, and the mechanism of glycogen accumulation in BAT during reacclimation

Jakus

Sándor

Janáky

et al. 2008

Journal of Lipid Research

Self Cite

View full text Add to dashboard Cite

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“…GYS activity in BAT was reported to be significantly increased by cold acclimation (29), but the glycogen content in BAT decreased by cold exposure (10,25). We observed an induction of Gys1 and Gys2 mRNA expression at days 2 and 4 of cold exposure, but no increase in GYS1/2 protein levels after 8 days.…”

Section: E386mentioning

confidence: 46%

Transcriptome profiling of brown adipose tissue during cold exposure reveals extensive regulation of glucose metabolism

Qin

Yadav

Basse

et al. 2015

American Journal of Physiology-Endocrinology and Metabolism

106

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We applied digital gene expression profiling to determine the transcriptome of brown and white adipose tissues (BAT and WAT, respectively) during cold exposure. Male C57BL/6J mice were exposed to cold for 2 or 4 days. A notable induction of genes related to glucose uptake, glycolysis, glycogen metabolism, and the pentose phosphate pathway was observed in BAT from cold-exposed animals. In addition, glycerol-3-phosphate dehydrogenase 1 expression was induced in BAT from cold-challenged mice, suggesting increased synthesis of glycerol from glucose. Similarly, expression of lactate dehydrogenases was induced by cold in BAT. Pyruvate dehydrogenase kinase 2 (Pdk2) and Pdk4 were expressed at significantly higher levels in BAT than in WAT, and Pdk2 was induced in BAT by cold. Of notice, only a subset of the changes detected in BAT was observed in WAT. Based on changes in gene expression during cold exposure, we propose a model for the intermediary glucose metabolism in activated BAT: 1) fluxes through glycolysis and the pentose phosphate pathway are induced, the latter providing reducing equivalents for de novo fatty acid synthesis; 2) glycerol synthesis from glucose is increased, facilitating triacylglycerol synthesis/fatty acid re-esterification; 3) glycogen turnover and lactate production are increased; and 4) entry of glucose carbon into the tricarboxylic acid cycle is restricted by PDK2 and PDK4. In summary, our results demonstrate extensive and diverse gene expression changes related to glucose handling in activated BAT.

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Glycogen‐binding protein STBD1: Molecule and role in pathophysiology

Tang

Liu

Zhao

et al. 2023

Journal Cellular Physiology

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Starch‐binding domain‐containing protein 1 (STBD1) is a glycogen‐binding protein discovered in skeletal muscle gene differential expression that is pivotal to cellular energy metabolism. Recent studies have indicated that STBD1 is involved in many physiological processes, such as glycophagy, glycogen accumulation, and lipid droplet formation. Moreover, dysregulation of STBD1 causes multiple diseases, including cardiovascular disease, metabolic disease, and even cancer. Deletions and/or mutations in STBD1 promote tumorigenesis. Therefore, STBD1 has garnered considerable interest in the pathology community. In this review, we first summarized the current understanding of STBD1, including its structure, subcellular localization, tissue distribution, and biological functions. Next, we examined the roles and molecular mechanisms of STBD1 in related diseases. Based on available research, we discussed the novel function and future of STBD1, including its potential application as a therapeutic target in glycogen‐related diseases. Given the significance of STBD1 in energy metabolism, an in‐depth understanding of the protein is crucial for understanding physiological processes and developing therapeutic strategies for related diseases.

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A Dramatic Accumulation of Glycogen in the Brown Adipose Tissue of Rats Following Recovery from Cold Exposure

Cited by 30 publications

References 27 publications

Cooperation between BAT and WAT of rats in thermogenesis in response to cold, and the mechanism of glycogen accumulation in BAT during reacclimation

Cooperation between BAT and WAT of rats in thermogenesis in response to cold, and the mechanism of glycogen accumulation in BAT during reacclimation

Transcriptome profiling of brown adipose tissue during cold exposure reveals extensive regulation of glucose metabolism

Glycogen‐binding protein STBD1: Molecule and role in pathophysiology

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