A doxycycline‐treated hydroxyapatite implant surface attenuates the progression of peri‐implantitis: A radiographic and histological study in mice

Lin, Ding; Zhang, Peng; Wang, Xin; Kasugai, Shohei

doi:10.1111/cid.12695

Cited by 18 publications

(16 citation statements)

References 32 publications

(72 reference statements)

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“…Nyon, Switzerland) [ 22 ]. A tetracycline hydrochloride powder was then mixed with saline solution (B. Braun, Melsugen AG, Germany) and applied on the surgical site for about 2 min [ 23 ]. Another cycle of copious irrigation with saline solution (B. Braun, Melsugen AG, Germany) for 1 min followed the previous step.…”

Section: Methodsmentioning

confidence: 99%

Peri-Implantitis: Application of a Protocol for the Regeneration of Deep Osseous Defects. A Retrospective Case Series

Verardi

Valente

2021

IJERPH

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Background and aims: Peri-implantitis is a complex pathology, both in its diagnosis and in the identification of etiological causes. Although we have been studying more and more over the years to try to answer the many questions that remain regarding everything that circulates around this disease which affects implants, nothing has yet been taken as an official consensus regarding its surgical treatment. There are still many proposed protocols, each of which has been shown to have comforting results and promising prospects, but no total predictability. The aim of this case series is to assess the clinical outcomes of a mixed protocol for the regeneration of deep osseous defects. Materials and methods: The data and clinical records of 23 patients, with 29 implants affected by peri-implantitis treated surgically in private practice, were analyzed retrospectively. The method used for the surgical treatment was a mixed protocol of mechanical–chemical decontamination and bone regeneration with bovine xenograft. Results: All patients were followed for at least 2 years, averaging 28.9 months (a range of 24–38 months) with a reduction in the probing depth (PD) at one year from the initial 8.14 ± 1.156 mm to 3.72 ± 0.649 mm, and to 4.14 ± 1.093 mm at the final assessment. The differences between assessment time points were always statistically significant. The data regarding bleeding on probing (BoP) and suppuration also showed a statistically significant reduction at the final time point compared to the baseline. Only one patient, at 24 months, still showed BoP, suppuration, and a PD deeper than 5 mm, indicating a recurrence of the disease compared to the initial improvement of the PD (5 mm) at one year. Conclusions: In conclusion, within the limits of this retrospective analysis, it can be affirmed that this combined mechanical–chemical and regenerative decontamination therapy is effective in the treatment of peri-implantitis.

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Section: Methodsmentioning

confidence: 99%

Peri-Implantitis: Application of a Protocol for the Regeneration of Deep Osseous Defects. A Retrospective Case Series

Verardi

Valente

2021

IJERPH

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“… Peri-implantitis was also obtained in a recent study of oral infection with Porphyromonas gingivalis [ 408 ]. Since the model has been well established, some applications have emerged, namely, analysis of the impact of different implant surfaces on peri-implantitis [ 409 ] or inflammation pathways [ 410 ]. Summary : Mice seem to be a promising model for genetic research thanks to the ability to perform knock-out studies and the availability of models of human disease.…”

Section: Appendix A1 Research In Non-human Primatesmentioning

confidence: 99%

Section: Appendix A1 Research In Non-human Primatesmentioning

confidence: 99%

Pre-Clinical Models in Implant Dentistry: Past, Present, Future

et al. 2021

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Biomedical research seeks to generate experimental results for translation to clinical settings. In order to improve the transition from bench to bedside, researchers must draw justifiable conclusions based on data from an appropriate model. Animal testing, as a prerequisite to human clinical exposure, is performed in a range of species, from laboratory mice to larger animals (such as dogs or non-human primates). Minipigs appear to be the animal of choice for studying bone surgery around intraoral dental implants. Dog models, well-known in the field of dental implant research, tend now to be used for studies conducted under compromised oral conditions (biofilm). Regarding small animal models, research studies mostly use rodents, with interest in rabbit models declining. Mouse models remain a reference for genetic studies. On the other hand, over the last decade, scientific advances and government guidelines have led to the replacement, reduction, and refinement of the use of all animal models in dental implant research. In new development strategies, some in vivo experiments are being progressively replaced by in vitro or biomaterial approaches. In this review, we summarize the key information on the animal models currently available for dental implant research and highlight (i) the pros and cons of each type, (ii) new levels of decisional procedures regarding study objectives, and (iii) the outlook for animal research, discussing possible non-animal options.

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“…Although results demonstrated successful antibiofilm effects, bacterial resistance against tetracyclines is common, and due to their photo-oxidative potential, tetracyclines can cause purple staining of teeth, limiting their use clinically [57,63]. However, their anti-inflammatory, antibacterial, anticollagenase, and immunosuppressive properties have seen the use of doxycyclines in bone scaffolds to promote bone growth and reduce peri-implantitis [64,65].…”

Section: Tetracyclinesmentioning

confidence: 99%

Antimicrobials in Dentistry

2021

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Dental caries (decay) is caused by pathogenic bacterial species, which afflicts nearly a third of the world′s population from early childhood to old age. Treatment of tooth decay often involves the use of filling materials to restore the cavity; however, if untreated, it can cause pain, infection and eventually lead to tooth loss. Since the oral environment is colonised by many different microorganisms, bacterial biofilms can form on these filling materials, contributing to secondary caries that can eventually lead to the failure of the dental restoration. Thus, preventing the formation of bacterial biofilms is an important strategy in the management of caries, which has led to research enabling antimicrobial capabilities in dental materials. Materials and pharmaceutical sciences are in a continuous race against microbial resistance but are trying to balance between beneficial biota associated with the oral cavity, and, of course, avoiding a harmful effect on tissues is challenging. This has, therefore, stemmed a substantial interest in both preventive and restorative measures that would enable limiting the formation of secondary caries, oral microbial biofilms, and the retention of tooth mineral. Thus, innovative strategies are being explored and here we present a review with a focus on strategies that can inhibit or limit the formation of bacterial biofilms.

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A doxycycline‐treated hydroxyapatite implant surface attenuates the progression of peri‐implantitis: A radiographic and histological study in mice

Cited by 18 publications

References 32 publications

Peri-Implantitis: Application of a Protocol for the Regeneration of Deep Osseous Defects. A Retrospective Case Series

Peri-Implantitis: Application of a Protocol for the Regeneration of Deep Osseous Defects. A Retrospective Case Series

Pre-Clinical Models in Implant Dentistry: Past, Present, Future

Antimicrobials in Dentistry

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