A Double Weibull Input Function Describes the Complex Absorption of Sustained-Release Oral Sodium Valproate

Biopharmaceutics of β-cyclodextrin derivative-based formulations of acitretin in sprague-dawley rats

“…We noticed that there was a secondary peak at about 7–9 h after dosing in the concentration‐versus‐time graph for rats given the acitretin suspension whereas such a phenomenon was not observed for the rats receiving RMBCD‐acitretin. A similar double‐peak phenomenon has been observed for some other oral drugs 38–40. Several mechanisms have been proposed to account for the phenomenon: enterohepatic recycling,41 discontinued or variable absorption along the gastrointestinal tract,42 and variable gastric emptying 43.…”

IN VITRO CHARACTERIZATION OF LAMOTRIGINEN2-GLUCURONIDATION AND THE LAMOTRIGINE-VALPROIC ACID INTERACTION

“…Because VPA is essentially completely absorbed from the gastrointestinal tract, f a is 1.0 (Bressolle et al, 1994). The absorption rate constant (k a ) for VPA was assumed to be 0.1/h (Ito et al, 2004).…”

Population In Vitro-In Vivo Correlation Model for Pramipexole Slow-Release Oral Formulations

“…The analysis of the in vitro data revealed that for all SR formulations, the model selected was the Weibull model. This model has been widely used to describe (i) the in vitro release kinetics of many different dosage formulations (23)(24)(25)(26) and (ii) although less frequently, the in vivo drug absorption process (27)(28)(29)(30).…”