A double safety lock tumor-specific device for suicide gene therapy in breast cancer

Piña, Maria J.; Girotti, Alessandra; Serrano, Sofía; Muñoz, Raquel; Rodríguez‐Cabello, José Carlos; Arias, Francisco J.

doi:10.1016/j.canlet.2019.11.031

Cited by 11 publications

(12 citation statements)

References 67 publications

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“…For example, researchers have developed an elastin-like recombinant (ELR) and specific MUC1 aptamers for intracellular delivery of the MUC1 gene to breast tumors [193]. More recently, the same group developed a double protection tumor-specific nanomaterial device for gene therapy in breast cancer [86]. The functionalized peptides/ligands can also improve the delivery of nucleic acid-complexed NPs to tumors [95,194,195].…”

Section: Breast Cancer Therapymentioning

confidence: 99%

In vivo gene delivery mediated by non-viral vectors for cancer therapy

Mohammadinejad

Dehshahri

Madamsetty

et al. 2020

Journal of Controlled Release

177

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Section: Breast Cancer Therapymentioning

confidence: 99%

In vivo gene delivery mediated by non-viral vectors for cancer therapy

Mohammadinejad

Dehshahri

Madamsetty

et al. 2020

Journal of Controlled Release

177

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“…Gene therapy is a new treatment modality for tumors. [113,114] A major problem associated gene therapy is the efficient transfer of genetic material to the tumor cells with minimal side effect. [115] Although viral vehicles can mediate gene transfer with high efficacy, [111] their high cost, triggering of host immune responses and security hinder their practical applications.…”

Section: Nanohydroxyapatite Enters the Tumorous Site As A Gene Transf...mentioning

confidence: 99%

The Janus Nature of Nanohydroxyapatite in Tumor Progression

Shen

Wan

et al. 2021

Adv Funct Materials

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Nanohydroxyapatite (nHAP) has broad applications because of its nanoscopical dimension, large specific surface area, biocompatibility, and low cytotoxicity. Researchers recently discovered that nHAP synthesized in vitro inhibits the growth of different types of tumor cells. Nanohydroxyapatite with potent drug adsorption and loading capacity has potential applications in tumor diagnosis and treatment. Because local tumors and areas of tumor metastasis also produce pathological nHAP in vivo to promote progression and invasion, the role of nHAP in tumorigenesis and development is perceived literature by many as Janus, the double‐faced deity in ancient Roman mythology. In the present review, two types of nHAP (those synthesized in vitro and those produced in vivo) that are affiliated with tumors, their mechanisms in tumor progression as well as their applications in tumor treatment are elucidated to create a backdrop for future research in this exciting, yet controversial arena.

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“…These innovative in vivo therapies were further developed by the same group in a more recent work [31] in which the authors described a double-lock device comprising the polyplex ELR-PEG-5TR1 loaded with therapeutic DNA, with which an increase in the potential harm with no damage to non-tumor cells could be achieved both in vitro and in vivo. The therapeutic agent designed for this research was pDhMUC1-ricin, which comprises the hMUC1 promoter, a MUC1 tumor-specific promoter, preprotrypsin leader sequence, and ricin gene.…”

Section: Cancer Therapymentioning

confidence: 99%

“…The first lock is the specificity of the 5TR1 aptamer for breast cancer cells, while the second lock ensures expression of the cytotoxic drug ricin in MUC1 overexpressing cells only. Indeed, the therapeutic DNA gene is under control of the hMUC1 promoter, while the preprotrypsin leader guarantees over-synthesis and ensures secretion of cytotoxic ricin to obtain a ripple effect in adjacent cells [31].…”

Section: Cancer Therapymentioning

confidence: 99%

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Aptamer-Functionalized Natural Protein-Based Polymers as Innovative Biomaterials

et al. 2020

Self Cite

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Biomaterials science is one of the most rapidly evolving fields in biomedicine. However, although novel biomaterials have achieved well-defined goals, such as the production of devices with improved biocompatibility and mechanical properties, their development could be more ambitious. Indeed, the integration of active targeting strategies has been shown to allow spatiotemporal control of cell–material interactions, thus leading to more specific and better-performing devices. This manuscript reviews recent advances that have led to enhanced biomaterials resulting from the use of natural structural macromolecules. In this regard, several structural macromolecules have been adapted or modified using biohybrid approaches for use in both regenerative medicine and therapeutic delivery. The integration of structural and functional features and aptamer targeting, although still incipient, has already shown its ability and wide-reaching potential. In this review, we discuss aptamer-functionalized hybrid protein-based or polymeric biomaterials derived from structural macromolecules, with a focus on bioresponsive/bioactive systems.

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A double safety lock tumor-specific device for suicide gene therapy in breast cancer

Abstract: Due to his experience with nanotechnology approaches applied to naturalderived biomaterials in order to obtain biomedical devices with improved structural and multifunctional properties, to control cell behaviour and organization, to be used in therapies.

Cited by 11 publications

References 67 publications

In vivo gene delivery mediated by non-viral vectors for cancer therapy

In vivo gene delivery mediated by non-viral vectors for cancer therapy

The Janus Nature of Nanohydroxyapatite in Tumor Progression

Aptamer-Functionalized Natural Protein-Based Polymers as Innovative Biomaterials

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