A double photon coincidence detection method for medical gamma-ray imaging

Uenomachi, Mizuki; Shimazoe, Kenji; Takahashi, Hiroyuki

doi:10.2478/bioal-2022-0080

Cited by 10 publications

(2 citation statements)

References 47 publications

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“…While the means for distinguishing between prompt and annihilation gamma ray signals may be feasible based on these findings, development of such a technique constitutes future work. We have demonstrated eventby-event discrimination based purely on ∆ϕ filtering yields poor but better than nothing classification results, as expected [26]. Despite this, Kim et al has recently demonstrated an in increase to signal-to-noise ratio in reconstructed images based solely on ∆ϕ filtered coincidence data [28].…”

Section: Discussionsupporting

confidence: 77%

Quantum Entanglement Filtering: A PET Feasibility Study in Imaging Dual-Positron and Prompt Gamma Emission via Monte Carlo Simulation

Romanchek,

Shoop,

Gholami

et al. 2024

IEEE Trans. Radiat. Plasma Med. Sci.

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In this article, we investigate quantum entanglement (QE) filtering to address the challenges in multi-isotope positron emission tomography (PET) or in PET studies utilizing radiotracers with dual-positron and prompt gamma emissions. Via GATE simulation, we demonstrate the efficacy of QE filtering using a one-of-a-kind cadmium zinc telluride (CZT) PET system -establishing its viability as a multimodal scanner and ability to perform QE filtering. We show the high Compton scattering probability in this CZT-based scanner with 44.2% of gammas undergoing a single scatter prior to absorption. Additionally, the overall system sensitivity as a standard PET scanner (11.29%), QE-PET scanner (6.81%), and Compton Camera (11.29%) is quantified. Further, we find a 23% decrease in the double Compton scatter (DCSc) frequency needed for QE filtering for each mm decrease in crystal resolution and an increase in mean absolute error (MAE) of their ∆ϕs from 6.8 o for 1 mm resolution to 9.5 o , 12.2 o , and 15.3 o for 2, 4, and 8 mm resolution, respectively. These results reinforce the potential of CZT detectors to lead next generation PET systems taking full advantage of the QE information of positron annihilation photons.

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Section: Discussionsupporting

confidence: 77%

Quantum Entanglement Filtering: A PET Feasibility Study in Imaging Dual-Positron and Prompt Gamma Emission via Monte Carlo Simulation

Romanchek,

Shoop,

Gholami

et al. 2024

IEEE Trans. Radiat. Plasma Med. Sci.

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“…On the other hand, this kind of cascade gamma emission has also been discussed for effective use as multi-photon imaging. 23,24) While the use of 124 I for o-Ps lifetime imaging would seem to be challenging, we focused on this radionuclide as it has been studied for such applications as dosimetry in 131 I thyroid cancer treatment, 25,26) imaging of various in vivo cancer tumors, 27) and immunoPET imaging using tumorspecific antibodies. 28,29) No report has appeared on the use of 124 I for o-Ps lifetime imaging as far as we know.…”

mentioning

confidence: 99%

Positron annihilation lifetime measurement with TOF-PET detectors: feasibility of Iodine-124 use

Takyu,

Ikeda,

Wakizaka

et al. 2023

Appl. Phys. Express

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Positronium (Ps) imaging is getting attention for nuclear medicine applications, but appropriate radionuclides have not been evaluated systematically. This paper investigated the use of 124I, which is a positron emitter with 603 keV prompt gamma ray emission with a fraction of 11.7%. The accuracy of Ps lifetime measurement with 124I was compared with 22Na, which is often used in Ps lifetime measurement, for certified reference materials. Results obtained with TOF-PET detectors suggested that accuracy of the lifetime value estimation was slightly worse than that for 22Na, while the Ps lifetime measurement using 124I was a feasible choice.

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Efficiency determination of J-PET: first plastic scintillators-based PET scanner

et al. 2023

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Background The Jagiellonian Positron Emission Tomograph is the 3-layer prototype of the first scanner based on plastic scintillators, consisting of 192 half-metre-long strips with readouts at both ends. Compared to crystal-based detectors, plastic scintillators are several times cheaper and could be considered as a more economical alternative to crystal scintillators in future PETs. JPET is also a first multi-photon PET prototype. For the development of multi-photon detection, with photon characterized by the continuous energy spectrum, it is important to estimate the efficiency of J-PET as a function of energy deposition. The aim of this work is to determine the registration efficiency of the J-PET tomograph as a function of energy deposition by incident photons and the intrinsic efficiency of the J-PET scanner in detecting photons of different incident energies. In this study, 3-hit events are investigated, where 2-hits are caused by 511 keV photons emitted in $$e^+e^-$$ e + e - annihilations, while the third hit is caused by one of the scattered photons. The scattered photon is used to accurately measure the scattering angle and thus the energy deposition. Two hits by a primary and a scattered photon are sufficient to calculate the scattering angle of a photon, while the third hit ensures the precise labeling of the 511 keV photons. Results By comparing experimental and simulated energy distribution spectra, the registration efficiency of the J-PET scanner was determined in the energy deposition range of 70–270 keV, where it varies between 20 and 100$$\%$$ % . In addition, the intrinsic efficiency of the J-PET was also determined as a function of the energy of the incident photons. Conclusion A method for determining registration efficiency as a function of energy deposition and intrinsic efficiency as a function of incident photon energy of the J-PET scanner was demonstrated. This study is crucial for evaluating the performance of the scanner based on plastic scintillators and its applications as a standard and multi-photon PET systems. The method may be also used in the calibration of Compton-cameras developed for the ion−beam therapy monitoring and simultaneous multi-radionuclide imaging in nuclear medicine.

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A double photon coincidence detection method for medical gamma-ray imaging

Cited by 10 publications

References 47 publications

Quantum Entanglement Filtering: A PET Feasibility Study in Imaging Dual-Positron and Prompt Gamma Emission via Monte Carlo Simulation

Quantum Entanglement Filtering: A PET Feasibility Study in Imaging Dual-Positron and Prompt Gamma Emission via Monte Carlo Simulation

Positron annihilation lifetime measurement with TOF-PET detectors: feasibility of Iodine-124 use

Efficiency determination of J-PET: first plastic scintillators-based PET scanner

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