A double Philadelphia chromosome-positive chronic myeloid leukemia patient, co-expressing P210<sup>BCR-ABL1</sup> and P195<sup>BCR-ABL1</sup> isoforms

Vinhas, Raquel; Lourenço, Alexandra; Santos, Susana; Ribeiro, Patrícia Lisbôa Izetti; Silva, Madalena Pereira da; Sousa, Aïda Botelho de; Baptista, Pedro V.; Fernandes, Alexandra R.

doi:10.3324/haematol.2018.192534

Cited by 6 publications

(6 citation statements)

References 14 publications

(6 reference statements)

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“…The results presented here show the antiproliferative potential of Cu-P and Fe/Cu-P beads per se (particularly the first ones) in K562 cells, thus supporting the future incorporation of Imatinib in those beads towards increasing this antiproliferative effect and their potential for chronic myeloid leukemia (CML) therapy [37] . The Fe-P beads, on the other…”

Section: Cytotoxic Evaluation Of Fucopol Beadssupporting

confidence: 68%

Cation-mediated gelation of the fucose-rich polysaccharide FucoPol: preparation and characterization of hydrogel beads and their cytotoxicity assessment

Fialho

Araújo

Alves

et al. 2019

International Journal of Polymeric Materials and Polymeric Biom

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This study describes for the first time the iron-and copper-mediated gelation of FucoPol, fucose-rich bacterial polysaccharide. The ability of FucoPol to gel in the presence of metal cations, including iron(III) and copper(II), was used for the preparation of hydrogel beads. Iron mediated the formation of stable and not cytotoxic gel beads, while copper resulted in fragile and cytotoxic ones. Copper-mediated beads coated with an iron-mediated gel layer were more stable and had reduced cytotoxicity.The resulting polymeric structures had differing morphology, physical properties and cytotoxicity, which support their use in several applications, including biomedicine, agriculture and bioremediation.

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Section: Cytotoxic Evaluation Of Fucopol Beadssupporting

confidence: 68%

Cation-mediated gelation of the fucose-rich polysaccharide FucoPol: preparation and characterization of hydrogel beads and their cytotoxicity assessment

Fialho

Araújo

Alves

et al. 2019

International Journal of Polymeric Materials and Polymeric Biom

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“…The hybrid oncogenetic protein BCR-ABL1 is responsible for the persistently elevated tyrosine kinase activity that perturbs cell proliferation, differentiation, and survival pathways. 17 In ALL, t (9;22) often occurs in patients diagnosed with B-ALL, and most cases express the p190 BCR-ABL1 transcript. 18 Ph-positive ALL patients show an aggressive leukemia with poor prognosis and high relapse rates due to standard therapies resistance.…”

Section: Discussionmentioning

confidence: 99%

A prognostic approach on a case of pediatric Philadelphia chromosome‐positive acute lymphoblastic leukemia with monosomy‐7

Skhoun

Khattab²,

Belkhayat³

et al. 2021

Clinical Case Reports

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“…The prognostic impact of variant translocations has been reported [53,[59][60][61][62][63][64][65][66]. Most studies indicate no difference to prognosis between standard and variant translocations [53,[59][60][61][62][63], but there have been demonstrations of the association of Ph variations with poorer prognosis [64][65][66][67].…”

Section: Variations Of the Philadelphia Chromosomementioning

confidence: 99%

“…Vinhas and collaborators presented a patient with CML that initiated Imatinib with different dosages for several months and failed to induce a cytogenetic response [67]. After deeper analysis, the patient presented with a double Ph-positive cells and two isoforms of the gene: P210 (e14a2) and a rare P195 (e6a2) with no point mutations in the ABL1 domain; while at the protein level, it showed BCR-ABL1 expression and phosphorylation of ABL1 kinase domain, linked to the pathogenesis of CML [67]. The patient initiated bosutinib, and after monitoring attained a DMR to P210 and stable to P195 [67].…”

Section: Double Ph-positive Karyotype In CMLmentioning

confidence: 99%

“…After deeper analysis, the patient presented with a double Ph-positive cells and two isoforms of the gene: P210 (e14a2) and a rare P195 (e6a2) with no point mutations in the ABL1 domain; while at the protein level, it showed BCR-ABL1 expression and phosphorylation of ABL1 kinase domain, linked to the pathogenesis of CML [67]. The patient initiated bosutinib, and after monitoring attained a DMR to P210 and stable to P195 [67]. This study highlighted the importance of identification of more than one transcript to promote a more appropriate TKI regimen for improved response in CML patients [67].…”

Section: Double Ph-positive Karyotype In CMLmentioning

confidence: 99%

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Genetic Biomarkers in Chronic Myeloid Leukemia: What Have We Learned So Far?

Abdulmawjood

Costa

Roma‐Rodrigues

et al. 2021

IJMS

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Chronic Myeloid Leukemia (CML) is a rare malignant proliferative disease of the hematopoietic system, whose molecular hallmark is the Philadelphia chromosome (Ph). The Ph chromosome originates an aberrant fusion gene with abnormal kinase activity, leading to the buildup of reactive oxygen species and genetic instability of relevance in disease progression. Several genetic abnormalities have been correlated with CML in the blast phase, including chromosomal aberrations and common altered genes. Some of these genes are involved in the regulation of cell apoptosis and proliferation, such as the epidermal growth factor receptor (EGFR), tumor protein p53 (TP53), or Schmidt-Ruppin A-2 proto-oncogene (SRC); cell adhesion, e.g., catenin beta 1 (CTNNB1); or genes associated to TGF-β, such as SKI like proto-oncogene (SKIL), transforming growth factor beta 1 (TGFB1) or transforming growth factor beta 2 (TGFB2); and TNF-α pathways, such as Tumor necrosis factor (TNFA) or Nuclear factor kappa B subunit 1 (NFKB1). The involvement of miRNAs in CML is also gaining momentum, where dysregulation of some critical miRNAs, such as miRNA-451 and miRNA-21, which have been associated to the molecular modulation of pathogenesis, progression of disease states, and response to therapeutics. In this review, the most relevant genomic alterations found in CML will be addressed.

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A double Philadelphia chromosome-positive chronic myeloid leukemia patient, co-expressing P210^BCR-ABL1 and P195^BCR-ABL1 isoforms

Cited by 6 publications

References 14 publications

Cation-mediated gelation of the fucose-rich polysaccharide FucoPol: preparation and characterization of hydrogel beads and their cytotoxicity assessment

Cation-mediated gelation of the fucose-rich polysaccharide FucoPol: preparation and characterization of hydrogel beads and their cytotoxicity assessment

A prognostic approach on a case of pediatric Philadelphia chromosome‐positive acute lymphoblastic leukemia with monosomy‐7

Genetic Biomarkers in Chronic Myeloid Leukemia: What Have We Learned So Far?

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A double Philadelphia chromosome-positive chronic myeloid leukemia patient, co-expressing P210BCR-ABL1 and P195BCR-ABL1 isoforms

Cited by 6 publications

References 14 publications

Cation-mediated gelation of the fucose-rich polysaccharide FucoPol: preparation and characterization of hydrogel beads and their cytotoxicity assessment

Cation-mediated gelation of the fucose-rich polysaccharide FucoPol: preparation and characterization of hydrogel beads and their cytotoxicity assessment

A prognostic approach on a case of pediatric Philadelphia chromosome‐positive acute lymphoblastic leukemia with monosomy‐7

Genetic Biomarkers in Chronic Myeloid Leukemia: What Have We Learned So Far?

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A double Philadelphia chromosome-positive chronic myeloid leukemia patient, co-expressing P210^BCR-ABL1 and P195^BCR-ABL1 isoforms