A double-network strategy for the tough tissue adhesion of hydrogels with long-term stability under physiological environment

Wang, Shuyang; Li, Jieru; Pan, Yue; Liu, Fengkai; Zeng, Liangsong; Gao, Yang; Lu, Tongqing

doi:10.1039/d2sm00688j

Cited by 12 publications

(5 citation statements)

References 42 publications

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“…The DN strategy also allows hydrogels to covalently bond to tissues and endure large strains, preventing cohesive failures. [ 13 ] Although DN hydrogels are durable, mechanical damage may yet occur over the long term. Self‐healing hydrogels utilizing reversible cross‐linking networks have emerged as long‐lasting bioadhesives that can reconstruct damaged structures.…”

Section: Introductionmentioning

confidence: 99%

A Mechanically Resilient and Tissue‐Conformable Hydrogel with Hemostatic and Antibacterial Capabilities for Wound Care

Park,

Kim,

Kim

et al. 2023

Advanced Science

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Hydrogels are used in wound dressings because of their tissue‐like softness and biocompatibility. However, the clinical translation of hydrogels remains challenging because of their long‐term stability, water swellability, and poor tissue adhesiveness. Here, tannic acid (TA) is introduced into a double network (DN) hydrogel consisting of poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) to realize a tough, self‐healable, nonswellable, conformally tissue‐adhesive, hemostatic, and antibacterial hydrogel. The TA within the DN hydrogel forms a dynamic network, enabling rapid self‐healing (within 5 min) and offering effective energy dissipation for toughness and viscoelasticity. Furthermore, the hydrophobic moieties of TA provide a water‐shielding effect, rendering the hydrogel nonswellable. A simple chemical modification to the hydrogel further strengthens its interfacial adhesion with tissues (shear strength of ≈31 kPa). Interestingly, the TA also can serve as an effective hemostatic (blood‐clotting index of 58.40 ± 1.5) and antibacterial component, which are required for a successful wound dressing. The antibacterial effects of the hydrogel are tested against Escherichia coli and Staphylococcus aureus. Finally, the hydrogel is prepared in patch form and applied to a mouse model to test in vivo biocompatibility and hemostatic performances.

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Section: Introductionmentioning

confidence: 99%

A Mechanically Resilient and Tissue‐Conformable Hydrogel with Hemostatic and Antibacterial Capabilities for Wound Care

Park,

Kim,

Kim

et al. 2023

Advanced Science

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“…35 However, a high level of HS at wound sites may cause bleeding and the short therapeutic duration of HS requires multiple administrations; hence, slow and sustained administration of HS at wound sites is demanded for improved outcome. 21,36 In this research, we thus fabricated a novel HS-loaded hydrogel (i.e., P 338 /CMCS-heparin composite hydrogel (PCHgel)) consisting of P 338 , CMSC, and CaCl 2 . The physical properties and biosafety of PCHgel were assessed, and the tissue adhesion ameliorating ability was evaluated in detail using a rat abdominal and cecum tissue abrasion model 37 (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have shown that heparin sodium (HS) also displays excellent tissue adhesion blocking capability by inhibiting macrophage adhesion and aggregation at damaged sites . However, a high level of HS at wound sites may cause bleeding and the short therapeutic duration of HS requires multiple administrations; hence, slow and sustained administration of HS at wound sites is demanded for improved outcome. , …”

Section: Introductionmentioning

confidence: 99%

Degradable Temperature-Sensitive Hydrogel Loaded with Heparin Effectively Prevents Post-Operative Tissue Adhesions

Lang

Liu

Huang

et al. 2023

ACS Biomater. Sci. Eng.

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Tissue adhesions could occur following surgeries, and severe tissue adhesions can lead to serious complications. Medical hydrogels could be applied at surgical sites as a physical barrier to prevent tissue adhesion. For practical reasons, spreadable, degradable, and self-healable gels are highly demanded. To meet these requirements, we applied carboxymethyl chitosan (CMCS) to poloxamer-based hydrogels to generate low Poloxamer 338 (P 338 ) content gels displaying low viscosity at refrigerator temperature and improved mechanical strength at body temperature. Heparin, an effective adhesion inhibitor, was also added to construct P 338 /CMCS-heparin composite hydrogel (PCHgel). PCHgel presents as a flowable liquid below 20 °C and could rapidly transform into gel when spread on the surface of damaged tissue due to temperature change. The introduction of CMCS enabled hydrogels to form a stable self-healable barrier at injured positions and slowly release heparin during the wound healing period before being degraded after ∼14 days. Ultimately, PCHgel significantly reduced tissue adhesion in model rats and displayed higher efficiency than P 338 /CMCS gel without heparin. Its adhesion suppression mechanism was verified, and it also displayed good biosafety. Therefore, PCHgel showed good clinical transformation potential with high efficacy, good safety, and ease of use.

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“…Furthermore, considering the use of hydrogels inside a human body in diverse biomedical applications, understanding the mechanical properties of completely swollen and equilibrated hydrogels in warm saline physiological conditions is important from the engineering perspective. [11,[26][27][28] Therefore, it is necessary to develop synthetic hydrogels with similar mechanical performance to soft, elastic, and tough bio-hydrogels that stably function under physiological conditions without performance deterioration while exhibiting deformation-rate independence.…”

Section: Introductionmentioning

confidence: 99%

Hysteresis‐Free, Elastic, and Tough Hydrogel with Stretch‐Rate Independence and High Stability in Physiological Conditions

Ji,

Kim,

Fan

et al. 2023

Small

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Many existing synthetic hydrogels are inappropriate for repetitive motions because of large hysteresis, and their mechanical properties in warm and saline physiological conditions remain understudied. In this study, a stretch‐rate‐independent, hysteresis‐free, elastic, and tough nanocomposite hydrogel that can maintain its mechanical properties in phosphate‐buffered saline of 37 °C similar to warm and saline conditions of the human body is developed. The strength, stiffness, and toughness of the hydrogel are simultaneously reinforced by biomimetic silica nanoparticles with a surface of embedded circular polyamine chains. Such distinctive surfaces form robust interfacial interactions by local topological folding/entanglement with the polymer chains of the matrix. Load transfer from the soft polymer matrix to stiff nanoparticles, along with the elastic sliding/unfolding/disentanglement of polymer chains, overcomes the traditional trade‐off between strength/stiffness and toughness and allows for hysteresis‐free, strain‐rate‐independent, and elastic behavior. This robust reinforcement is sustained in warm phosphate‐buffered saline. These properties demonstrate the application potential of the developed hydrogel as a soft, elastic, and tough bio‐strain sensor that can detect dynamic motions across various deformation speeds and ranges. The findings provide a simple yet effective approach to developing practical hydrogels with a desirable combination of strength/stiffness and toughness, in a fully swollen and equilibrated state.

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A double-network strategy for the tough tissue adhesion of hydrogels with long-term stability under physiological environment

Abstract: Achieving tough and stable tissue adhesion under physiological environment is of great significance for the clinical applications of hydrogel adhesives. The current tough hydrogel adhesives face the challenge in preservation...

Cited by 12 publications

References 42 publications

A Mechanically Resilient and Tissue‐Conformable Hydrogel with Hemostatic and Antibacterial Capabilities for Wound Care

A Mechanically Resilient and Tissue‐Conformable Hydrogel with Hemostatic and Antibacterial Capabilities for Wound Care

Degradable Temperature-Sensitive Hydrogel Loaded with Heparin Effectively Prevents Post-Operative Tissue Adhesions

Hysteresis‐Free, Elastic, and Tough Hydrogel with Stretch‐Rate Independence and High Stability in Physiological Conditions

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