A double-masked, placebo-controlled study of the efficacy and safety of premeal ranitidine in the prevention or reduction of heartburn

Pappa, Keith A.; Buaron, Kathy S.; Mandich, Malijana; Sirgo, Mark A.; Williams, Benjamin O.; Payne, John E.; Witham, Lori A.; Ciociola, Arthur A.

doi:10.1016/s0011-393x(98)85083-2

Cited by 3 publications

(11 citation statements)

References 14 publications

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“…Two trials evaluated the patients’ assessment of ‘improved’ symptoms at the end of the treatment period. The combined ABI of H2RAs over placebo was 16% (95% CI: 7.9–23.3%, P < 0.0001); the RBI was 0.29 (95% CI: 0.14–0.41); the NNT was 6 (95% CI: 4–13) 6, 15 …”

Section: Resultsmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10][11] A hand search of cited bibliographies resulted in four additional articles that met inclusion and exclusion criteria. [12][13][14][15] A contact of US manufacturers of antacids, alginates, and H2-blockers resulted in one unpublished study that met inclusion and exclusion criteria. 16 Overall, we reviewed 14 papers containing 18 comparisons.…”

Section: Resultsmentioning

confidence: 99%

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Meta‐analysis: the efficacy of over‐the‐counter gastro‐oesophageal reflux disease therapies

Tran

Lowry

El–Serag

2006

Aliment Pharmacol Ther

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Meta‐analysis: the efficacy of over‐the‐counter gastro‐oesophageal reflux disease therapies

Tran

Lowry

El–Serag

2006

Aliment Pharmacol Ther

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“…Research Triangle Park, NC: Glaxo Wellcome Inc., 1994) 17 . A subsequent trial 19 demonstrated the effectiveness of ranitidine 75 mg in reducing heartburn symptoms when administered 60 min prior to a challenge meal. The data in this investigation demonstrate that patients with a history of meal‐induced heartburn should find ranitidine 75 mg to be safe and effective in completely preventing or reducing heartburn symptoms when taken 30 min prior to consuming food and beverages anticipated to provoke heartburn.…”

Section: Discussionmentioning

confidence: 99%

“…The capacity of ranitidine to successfully reduce gastric acid secretion at lower than prescription doses, 16 display efficacy in the treatment of heartburn, 17 and its favourable safety profile 18 led to its approval for non‐prescription use in the relief of heartburn, acid indigestion and sour stomach in 1995. Subsequently, ranitidine 75 mg was shown to be effective in reducing heartburn symptoms when administered 60 min prior to a challenge meal 19 . In the current double‐blind study, the safety and effectiveness of ranitidine 75 mg in preventing or reducing heartburn symptoms was evaluated when taken 30 min prior to a provocative meal.…”

Section: Introductionmentioning

confidence: 98%

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A double‐blind, placebo‐controlled study of the efficacy and safety of non‐prescription ranitidine 75 mg in the prevention of meal‐induced heartburn

Pappa

Williams

Payne

et al. 1999

Aliment Pharmacol Ther

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Background : Ranitidine 75 mg (Zantac 75) has been shown to be effective for the treatment of pre‐existing heartburn symptoms. Aim : To compare the efficacy of dosing ranitidine 75 mg or placebo 30 min prior to a proven heartburn‐provoking meal in completely preventing or reducing subsequent heartburn symptoms. Methods : A randomized, double‐blind, parallel methodology was used at nine investigative centres. Following a screening visit, patients ate a standard test meal consisting of chilli, chips and a soft drink on two occasions. On the first occasion, patients received single‐blind placebo 30 min before the meal. This meal was used to qualify patients and to ensure the onset of a minimum level of heartburn. Patients who qualified were randomized (n = 284) to receive double‐blind ranitidine 75 mg or placebo 30 min before a second test meal administered 4–14 days later at the treatment visit. Patients recorded whether heartburn was present and rated heartburn severity by completing visual analogue scales at 15‐min intervals over the 4.5 h meal evaluation periods. Results : Statistically significant differences favouring ranitidine 75 mg were determined for complete prevention of heartburn (P < 0.006), heartburn severity area under the curve (P < 0.001), a clinical success end‐point (P < 0.001), and all other end‐points (P < 0.001). Conclusions : These data clearly demonstrate that ranitidine 75 mg is effective in completely preventing or decreasing heartburn when administered 30 min prior to a provocative meal.

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Theoretical ab initio study of ranitidine

Martins

Perez

Silva

et al. 2002

Int J of Quantum Chemistry

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ABSTRACT:The presence of a heterocyclic ring containing a basic center linked via a methylene chain to a substituted guanidine or thiourea polar side chain, such as found in the H2-antagonist metiamide, which has an imidazole heterocyclic ring, has often been identified as one of the requirements for H2-antagonist activity. In ranitidine, on the other hand, the imidazole ring is substituted for a furan ring, yielding a more active biological H2 antagonist. In this work, we have used the ab initio Hartree-Fock (HF) and second-order Møller-Plesset (MP2) methods in order to investigate the open and folded ranitidine conformations, of the type observed in metiamide. Five basis sets (3-21G, 3-21+G * * , 6-31G, 6-31+G * * , and 6-31+G * * ) were used in order to obtain fully optimized geometric parameters that indicated good agreement with the experimental crystallographic data. We have also investigated in this work the effects of solvents in both ranitidine and metiamide. Monocationic ranitidine was also investigated. All our results, indicate that, as in metiamide, the folded conformation is also preferred. We have investigated Mulliken and natural bond order (NBO) charge distributions, electrostatic and hydrogen bond effects on stabilizing the conformations and discussed the interactions of ranitidine with the biological receptor.

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A double-masked, placebo-controlled study of the efficacy and safety of premeal ranitidine in the prevention or reduction of heartburn

Cited by 3 publications

References 14 publications

Meta‐analysis: the efficacy of over‐the‐counter gastro‐oesophageal reflux disease therapies

Meta‐analysis: the efficacy of over‐the‐counter gastro‐oesophageal reflux disease therapies

A double‐blind, placebo‐controlled study of the efficacy and safety of non‐prescription ranitidine 75 mg in the prevention of meal‐induced heartburn

Theoretical ab initio study of ranitidine

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