A Double-Edged Sword: Roles of Helicobacter Pylori in Gastric Carcinoma

Xue, Lijun; Su, Qi; Mao, Xiaobei; Liu, Xiao-Bei; Lin, Qiang; Liu, Chang; Lin, Yunfeng; Yang, Jihong; Yu, Hong-Ju; Chen, Xiaoyuan

doi:10.5772/16691

Search citation statements

Order By: Relevance

Paper Sections

Select...

Ii22 Helicobacter Pylori1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2014

2018

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 182 publications

(156 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This immune-genicity is thought to be enhanced by the discovery that Cpn60 is a H. pylori cell surface protein [34]. However, of particular interest are the reports that the cell surface H. pylori Cpn60 protein may be involved in the process of gastric carcinoma formation [35] and its function as an adhesion for binding to human epithelial cells [4]. II.2.3 M. tuberculosis: Two Cpn60 proteins (60.1 and 60.2), with 60% sequence identity, are found in this bacterium [43].…”

Section: Ii22 Helicobacter Pylorimentioning

confidence: 99%

Multitasking Bacterial Moonlighting Proteins in Bacterial Virulence and Infectious Disease

Molan¹

2014

IOSRJDMS

View full text Add to dashboard Cite

Section: Ii22 Helicobacter Pylorimentioning

confidence: 99%

Multitasking Bacterial Moonlighting Proteins in Bacterial Virulence and Infectious Disease

Molan¹

2014

IOSRJDMS

View full text Add to dashboard Cite

InsideHelicobacter pylori: A Serious Threat to Humans

Rehman¹

2018

Avicenna J Clin Microbiol Infect

View full text Add to dashboard Cite

Helicobacter pylori is a close relative of Campylobacter species, with the ability to colonize the human gastrointestinal tract. This gastric pathogen is a flagellated, Gram-negative bacterium. Chronic gastritis, mucosa-associated lymphoid tissue (MALT) lymphoma, duodenal ulcer, and gastric ulcer are the outcomes of persistent infection with this pathogen. Recent studies have shown a direct relationship between H. pylori and development of gastric adenocarcinoma. A 7-to 14-day course of broad-spectrum antibiotics is required for the elimination of H. pylori. Treatment failure due to chromosomally encoded antibiotic resistance is increasing rapidly, which underlines the importance of new regimens against this pathogen. The vast diversity of natural compounds in living microorganisms such as algae, as well as various dietary components in herbs and foods, provides a new opportunity for the establishment of therapeutic compounds. The majority of intra-and extracellular metabolites in algae have potent inhibitory effects on H. pylori, leading to the development of novel therapeutic agents for gastric ulcer. Application of bioinformatics-based tools has encouraged the scientific community to find novel targets and have led to the development of in silico drugs against the pathogenic elements of H. pylori. Further research on metabolite-based therapeutic agents with the aid of modern tools can be a milestone in the management of the emerging risk of gastric ulcer.

show abstract

A Double-Edged Sword: Roles of Helicobacter Pylori in Gastric Carcinoma

Cited by 2 publications

References 182 publications

Multitasking Bacterial Moonlighting Proteins in Bacterial Virulence and Infectious Disease

Multitasking Bacterial Moonlighting Proteins in Bacterial Virulence and Infectious Disease

InsideHelicobacter pylori: A Serious Threat to Humans

Contact Info

Product

Resources

About