A double-chamber rotating bioreactor for the development of tissue-engineered hollow organs: From concept to clinical trial

Asnaghi, M. Adelaide; Jungebluth, Philipp; Raimondi, Manuela Teresa; Dickinson, Sally C.; Rees, Len; Go, Tetsuhiko; Cogan, Tristan A; Dodson, A; Parnigotto, Pier Paolo; Hollander, Anthony P.; Birchall, Martin A.; Conconi, Maria Teresa; Macchiarini, Paolo; Mantero, Sara

doi:10.1016/j.biomaterials.2009.07.018

Cited by 95 publications

(71 citation statements)

References 36 publications

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“…An alternative prevailing approach has been the application of mesenchymal stem cellderived chondrocytes. 27,36,37 Despite the major advantages of clinical availability and processing protocols, results remain unsatisfactory. Since mesenchymal stem cells reside in adipose tissue and provide an effortless source for harvest, multiple studies have attempted to use adipose-derived mesenchymal stem cells.…”

Section: Cell Sourcesmentioning

confidence: 99%

Tissue Engineering of the Trachea: What is the Hold-up?

Siddiqi¹,

Wit²,

Timman³

et al. 2017

MOJCSR

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Tissue-engineering of the trachea is called for based on the clinical consequences of airway pathology. Recent years have witnessed various reports from the tissueengineering field including a few cases of clinical patients receiving an engineered airway. Multiple fields have accelerated in parallel with the concept of tissue decellularization, isolation of stem cells and possible insights in the biology of different stem cells. Yet, a clinical trial using a tissue-engineered trachea is yet to be initiated. What is the hold-up? Are the hurdles predominantly in the matrix field or cellular regeneration field or both? This systematic review is an attempt to evoke question on what the hold-up might be in the journey of successful regeneration of a functional airway.

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Section: Cell Sourcesmentioning

confidence: 99%

Tissue Engineering of the Trachea: What is the Hold-up?

Siddiqi¹,

Wit²,

Timman³

et al. 2017

MOJCSR

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“…In vitro systems include physiologic, metabolic and biomechanical parameters required for the target tissue [4,9]. Various kinds of bioreactors have been developed including spinner-flask, rotating-wall, compression, strain, hydrostatic, flow-perfusion, and combinatorial bioreactors for clinical transplantation of the scaffolds [2,[26][27][28]. In vivo bioreactor concept was based on the use of the own body as a natural bioreactor.…”

Section: Bioreactorsmentioning

confidence: 99%

Current status of tracheal tissue engineering

Kumbasar¹,

Uysal²

2017

Curr Thorac Surg

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Management of large airway defects is challenging for clinicians due to lack of effective treatment modalities and eventually interest has turned to the field of airway tissue engineering. Considerable progress has been made within the field of airway tissue engineering in recent years and herein we review these recent advances within this field as applied to regeneration and/or replacement of the trachea. Although there are many encouraging researches, we are still far from any routine clinical application of tissue engineered tracheal grafts and it is essential to perform further experimental and clinical researches in order to improve current results and to broaden the clinical application of airway tissue engineering.

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“…In the first example, seeding of tubular, biodegradable scaffolds with autologous urothelial and smooth muscle cells was shown to catalyze regeneration of a complete bladder with laminarly organized histology and associated urologic functionality upon implantation within seven pediatric patients (Atala et al, 2006). In the second example, a tissue engineered, functional human trachea was created using a decellularized, cadaveric tracheal segment as scaffold and seeded with autologous respiratory epithelial cells and chondrocytes generated by the directed differentiation of the patient's own bone marrow cells (Asnaghi et al, 2009;Macchiarini et al, 2008). Both studies leveraged a scaffold seeded with autologous cells to trigger a regenerative response within the patient, ultimately leading to complementation of organ functionality with concomitant histogenesis of laminarly organized tissue structures.…”

Section: Tissue Engineering Of Tubular Organsmentioning

confidence: 99%