A double-blind trial of methocarbamol versus placebo in painful muscle spasm

Valtonen, Elisa

doi:10.1185/03007997509114791

Cited by 38 publications

(12 citation statements)

References 5 publications

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“…Internists have used this drug effectively for many years for patients with low back pain [5]. Considered a good treatment for muscle spasm [14], methocarbamol is a centrally acting muscle relaxant with a mildly sedating and anxiolytic effect at the central nervous system level [4]. This agent has a low likelihood for abuse [11], and has been used effectively in combination with narcotics for relief of postoperative chest pain after surgical placement of breast implants [12].…”

Section: Discussionmentioning

confidence: 99%

Reduced hospitalization cost for patients with pectus excavatum treated using minimally invasive surgery

et al. 2003

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These data demonstrate for the first time that the use of an alternate pain management strategy including, narcotics, NSAIDs, and methocarbamol, but without epidural catheters, results in reduced hospital length of stay and decreased overall hospitalization costs for MIRPE, as compared with open pectus repair. This cost benefit was achieved without compromising pain management or patient satisfaction with surgical care.

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Section: Discussionmentioning

confidence: 99%

Reduced hospitalization cost for patients with pectus excavatum treated using minimally invasive surgery

et al. 2003

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“…Theimprovements were significant for sevent onine days of therapy butdecreased in magnitudeo vert ime.T he authors hypothesized thatthis wasdue to the self-limiting nature of the injuriesstudied. Asimilarstudy (29) found similari mprovements with the incidenceo fs ide effectse qualt ot hato ft he placebo.…”

Section: Vetcomp Orthoptraumatol4/2005mentioning

confidence: 70%

“…Methocarbamol is ac entrallya cting musclerelaxantthatselectivelyblocks polysynapticreflexpathwaysinthe spinalcord without anye ffect on monosynapticp athways.I td oesn ot have anyd irect effect on the contractile elements of skeletal muscle, the somatic nerves, or the motor endp late (29),and itspharmacokinetics in dogs have been established ( 8). One early placebocontrolled study evaluated the efficacyo f methocarbamol in humans with acute musclepaindue to traumatic or inflammatoryi njury ( 28).…”

Section: Vetcomp Orthoptraumatol4/2005mentioning

confidence: 99%

Diagnosis and treatment of hind limb muscle strain injuries in 22 dogs

Nielsen¹,

Pluhar

2005

Vet Comp Orthop Traumatol

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The anamnesis was obtained from the medical records of 22 dogs diagnosed with hind limb muscle strain injury over a four-year period. The signalment, history, diagnostic imaging and clinical findings, treatment and outcome are described. The affected dogs were primarily from large breeds. Although only a few clients reported a specific injury, 11 dogs were admitted for an acute onset of lameness of unknown origin. The hip adductor muscles were affected in 21 dogs, and 11 dogs had previously undergone orthopaedic surgery of the affected limb. The dogs were primarily diagnosed by physical examination, although the diagnosis was confirmed with ultrasound imaging in the two most recent cases. Neither concurrent orthopoedic nor neurological disease was found during the study period in four of 22 dogs, and another three dogs had only mild radiographic coxofemoral osteoarthritis that did not cause any clinical signs during the study period. All of the dogs were treated medically with some combination of rest, physical therapy, methocarbamol, and a non-steroidol anti-inflammatory drug (NSAID). The injury-associated lameness improved, or completely resolved, with conservative, non-surgical therapy in most dogs. Of the 15 dogs available for follow-up (mean 577 days), eight had complete resolution of their clinical signs, two showed significant improvement, and one showed some improvement. Muscle strain injury may be an under-diagnosed cause or contributor to acute hind limb lameness in large breed dogs, either alone or following orthopoedic surgery.

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“…Relief of acute painful musculoskeletal conditions Dosage 1500 mg,four times daily Oral Physician's Desk Reference (2003), Valtonen (1975), Tisdale and Ervin (1975) Reduce dose to 750 mg every 4 h or 1500 mg three times daily for maintenance.…”

Section: Reference Commentsmentioning

confidence: 99%

Methocarbamol

Scholar¹

2007

xPharm: The Comprehensive Pharmacology Reference

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A double-blind trial of methocarbamol versus placebo in painful muscle spasm

Cited by 38 publications

References 5 publications

Reduced hospitalization cost for patients with pectus excavatum treated using minimally invasive surgery

Reduced hospitalization cost for patients with pectus excavatum treated using minimally invasive surgery

Diagnosis and treatment of hind limb muscle strain injuries in 22 dogs

Methocarbamol

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