A double-blind trial of four medications to treat severe premenstrual syndrome

Diêgoli, Mara Solange Carvalho; Fonseca, Ângela Maggio da; Diegoli, Carlos Alberto; Pinotti, José Aristodemo

doi:10.1016/s0020-7292(98)00035-6

Cited by 52 publications

(21 citation statements)

References 4 publications

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“…Thus, it is not thought that the medications cause the symptoms, but that their use is a consequence of PMS. Good results in relation to PMS are being obtained today through treatment using antidepressives 6 and, during some symptomatic periods, anxiolytics, 10 since the symptoms of PMS have the same nature as those of depression and anxiety. The fact that only 20% of the women with PMS as defined in the present study were utilizing some form of treatment can be highlighted.…”

Section: Discussionmentioning

confidence: 99%

Estudo populacional de síndrome pré-menstrual

et al. 2006

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ObjectiveTo study the prevalence of premenstrual syndrome and the factors associated with this, by comparing the obtained frequency with the self-reported frequency. Methods This was a cross-sectional population-based study, involving 1,395 women aged 15 to 49 years old in a medium-sized municipality in Southern Brazil, carried out in 2003. Questionnaires were applied to measure the prevalence of premenstrual syndrome by means of a score based on five premenstrual symptoms that interfered with family life or led to absence from work or school. Associations with socioeconomic, demographic and behavioral variables were investigated. Self-reported syndrome was investigated with regard to its sensitivity and specificity, taking the score as the gold standard. The statistical analyses performed were Pearson χ 2 , Mantel-Haenszel and Poisson regression, with Kappa coefficients to verify the concordance of the responses. ResultsThe obtained prevalence was 25.2% (95% CI: 22.5-27.9) and the self-reported prevalence was 60.3% (95% CI: 57.4-63.3). The principal premenstrual symptoms found were: irritability, abdominal discomfort, nervousness, headache, fatigue and breast pain; all of these showed prevalence of over 50%. Higher risk was presented by women of higher socioeconomic level, better schooling level, aged under 30 years and with white skin color. Psychotropic drug users and women who were not using any hormonal contraceptive presented higher prevalence of the syndrome. The sensitivity of the test was 94%, specificity 51% and accuracy 62%. Conclusions A high prevalence of premenstrual syndrome was found. Even though the women's perception of the syndrome was higher than the result measured by the symptom score, one quarter of the women presented this health problem.symptoms during the premenstrual period that are presented by the majority of women, and which do not interfere in the daily routine, are not considered to form part of the diagnosis of PMS. For the symptoms to be considered to represent the syndrome, it is necessary that some impediment be reported with regard to routine activities at work, at school or in social activities.

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Section: Discussionmentioning

confidence: 99%

Estudo populacional de síndrome pré-menstrual

et al. 2006

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“…All of them are efficacious in no more than 60% of women with PMDD. The selective preference between Sertraline [29][30][31][32][33][34][35][36][37][38], paroxetine [39][40][41], fluoxetine [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57], citalopram [58,59] and venlafaxine [60] is actually per the clinician's experience and personal preference. Intermittent luteal dosing has been demonstrated to be as effective as continuous dosing [31,33,36,37,57,61].…”

Section: The Recommended Treatment Algorithmmentioning

confidence: 99%

Algorithm for treatment of Premenstrual Syndromes (PMS): Experts' recommendations and limitations

Halbreich¹

2005

Gynecological Endocrinology

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The number of women who seek treatment for Premenstrual Syndromes (PMS) is continually increasing. To meet their needs there are many treatment modalities that have been introduced to clinical practice. In order to assist the clinician in choosing treatment for his/her patients, treatment recommendations by experts in the field are not only available but they may also be prioritized and sequenced as treatment algorithm. Such an algorithm for treatment of women with PMS is presented here. The algorithm is the author's summary and common denominator of several experts' consensus building group processes. The strengths as well as shortcomings of the experts' opinions processes are discussed. Substantial clinically-relevant research and assessments are still needed.

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“…Although anxiolytics such as alprazolam have been shown to be somewhat effective in patients with PMS (Berger & Presser 1994;Freeman et al 1995b;Diegoli et al 1998), treatment using anxiolytic agents is not recommended because of their potential for drug dependence and the variable effectiveness for the relief of PMS symptoms over time.…”

Section: Non-pharmacologic Treatments Of Pmsmentioning

confidence: 99%

A Controlled Trial of Chinese Herbal Medicine for Premenstrual Syndrome

Chou¹,

Morse²,

Xu³

et al. 2009

Deutsche Zeitschrift für Akupunktur

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Premenstrual syndrome is a common disorder troubling many women during their reproductive years. The Chinese have been using herbal medicines to treat menstrual cycle related symptoms for centuries. Traditional Chinese medicine provides the aetiology and pathogenesis of the symptoms of this disorder by applying Pattern Identification to diagnose the signs and symptoms of individual patients and to design individualised treatments which seek to address the entire pattern/s of disharmony. It follows that PMS, which has many symptoms and an idiosyncratic nature, is precisely an area for which Chinese medicine is most suitable. The aim of this study is to scientifically evaluate the effectiveness of Chinese herbal medicine on Australian women for the treatment of PMS within the theoretical frame-work of TCM. A double-blind randomized placebo-controlled crossover clinical trial was conducted by a qualified Chinese herbal practitioner and pharmacist. Following two months confirmatory assessment, sixty-one subjects were assigned randomly into two groups within different TCM patterns of Liver Qi Stagnation, Liver and Kidney Yin Deficiency, Liver and Spleen Disharmony and Heart and Spleen Deficiency. Herbal medicine (n=31) and placebo (n=30) were provided sequentially for a period of three months. There were significant differences (p < .01) in scores after three months of treatment between Chinese herbal medicine and placebo in premenstrual physical and psychological symptoms, depression, anxiety and anger, but with no difference in perceived stress (p > .05). There were highly significant reductions (p< .001) in all assessments in both groups except that a significant result (p < .05) was recorded on perceived

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A double-blind trial of four medications to treat severe premenstrual syndrome

Abstract: Fluoxetine in 10-mg doses presented the best results for treating premenstrual syndrome.

Cited by 52 publications

References 4 publications

Estudo populacional de síndrome pré-menstrual

Estudo populacional de síndrome pré-menstrual

Algorithm for treatment of Premenstrual Syndromes (PMS): Experts' recommendations and limitations

A Controlled Trial of Chinese Herbal Medicine for Premenstrual Syndrome

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