A Double-Blind Trial of Clomipramine in Premature Ejaculation

Girgis, S. M.; El-Haggar, Sahar Mohamed; El‐Hermouzy, S.

doi:10.1111/j.1439-0272.1982.tb02278.x

Cited by 68 publications

(19 citation statements)

References 4 publications

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“…The current treatment choice for PE is medical treatment. Systemic treatments have included adrenergic antagonists (Beretta et al, 1986), c-aminobutyric acid, and selective serotonin reuptake inhibitors (Girgis et al, 1982;Kara et al, 1996;McMahon, 1998;McMahon and Touma, 1999 a,b;Andersson et al, 2006). Success with these agents has been variable and is associated with side effects.…”

Section: Discussionmentioning

confidence: 99%

A Novel Treatment Modality in Patients With Premature Ejaculation Resistant to Conventional Methods: The Neuromodulation of Dorsal Penile Nerves by Pulsed Radiofrequency

Başal

Göktaş

Ergin

et al. 2010

Journal of Andrology

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Premature ejaculation (PE) is the most common sexual problem experienced by men, and it affects 20%-30% of them. Pulsed radiofrequency (PRF) neuromodulation has been shown to be an effective treatment for a wide range of pain conditions. We used PRF to treat PE by desensitizing dorsal penile nerves in patients resistant to conventional treatments. Fifteen patients with a lifelong history of PE, defined as an intravaginal ejaculatory latency time (IELT) of ,1 minute that occurred in more than 90% of acts of intercourse and was resistant to conventional treatments, were enrolled in this study. Patients with erectile dysfunction were excluded. The mean age of the patients was 39 6 9 years. Before and 3 weeks after the treatment, IELT and sexual satisfaction score (SSS; for patients and their partners) were obtained. The mean IELTs before and 3 weeks after procedure were 18.5 6 17.9 and 139.9 6 55.1 seconds, respectively. Side effects did not occur. Mean SSSs of patients before and after treatment were 1.3 6 0.3 and 4.6 6 0.5, and mean SSSs of partners before and after treatment were 1.3 6 0.4 and 4.4 6 0.5, respectively. In all cases, IELT and SSS were significantly increased (P , .05). None of the patients or their wives reported any treatment failure during the follow-up period. The mean follow-up time was 8.3 6 1.9 months. It is early to conclude that this new treatment modality might be used widely for the treatment of PE; however, because it is an innovative modality, placebo-controlled studies (eg, sham procedure), with larger numbers of patients and including assessment of penile sensitivity (eg, biothesiometry), are needed.

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Section: Discussionmentioning

confidence: 99%

A Novel Treatment Modality in Patients With Premature Ejaculation Resistant to Conventional Methods: The Neuromodulation of Dorsal Penile Nerves by Pulsed Radiofrequency

Başal

Göktaş

Ergin

et al. 2010

Journal of Andrology

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“…Delayed ejaculation is a common side-effect of many antidepressant drugs, particularly the serotoninergic antidepressant clomipramine [ 3 ] and the SSRIs fl uoxetine, paroxetine, and sertraline [ 4 -6 ] . These drugs increase the level of synaptic serotonin, presumably inhibiting the ejaculatory refl ex, and thereby prolong intra-vaginal ejaculatory latency time (IELT).…”

Section: Existing Treatment Optionsmentioning

confidence: 99%

The role of local anaesthetics in premature ejaculation

Wyllie

Powell²

2012

BJU International

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E 9 4 3What ' s known on the subject? and What does the study add? It is now accepted that both biological and psychological factors are important in the aetiology of premature ejaculation (PE). Of particular interest is the correlation between ejaculatory latency and penile sensory thresholds. Men with PE appear to have a heightened sensory response to penile stimulation and also generally exhibit other abnormal refl ex pathways within the ejaculatory process, suggesting a link between penile hypersensitivity and PE. Considering these sensory differences, drugs that selectively produce some degree of penile desensitization or act within the afferent-efferent refl ex could delay ejaculatory latency without adversely affecting the sensation of ejaculation.This review evaluates published clinical trial data for local anaesthetics used off-label in PE as well as novel topical agents in development. New analyses of the phase III data are presented for topical eutectic mixture for PE (TEMPE, also known as PSD502, Plethora Solutions Plc., London), a proprietary formulation of lidocaine and prilocaine in a metered-dose aerosol delivery system.

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“…27,28 PE has been treated with various modalities, including behavioural therapy 3 , topical anaesthetic creams or sprays, 29 and off-label use of oral pharmacotherapy, such as phosphodiesterase-5 inhibitors, 30 selective serotonin reuptake inhibitors (SSRIs) (fluoxetine, citalopram and duloxetine), 31 and a tricyclic antidepressant (clomipramine) that blocks serotonin, dopamine and norepinephrine transporters. 32 These modalities are associated with variable rates of success when taken daily, 33,34 and intracavernosal vasoactive drug injection has also been reported. 35 In contrast, some reports suggest that these drugs may be effective when received as needed.…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation

Eassa¹,

El-Shazly²

2012

Asian J Androl

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Premature ejaculation (PE) is the most common sexual disorder. It affects 20%-30% of adult men; the aetiology of this condition has not yet been elucidated. The aim of this study is to evaluate the efficacy, safety, tolerability, undesirable effects and improved satisfaction with sexual intercourse with tramadol hydrochloride at different dosages for the treatment of PE. A total of 300 patients who presented with lifelong (primary) PE were included in this study. The study was performed for 28 weeks, in which placebo (starch tablet) was given for 4 weeks, and active ingredient (tramadol hydrochloride) was administered at different therapeutic dosages for 24 weeks. Patients were divided into three equal groups, each consisting of 100 patients. The first group (A) was given tramadol hydrochloride capsule 25 mg. The second group (B) was given tramadol hydrochloride capsule 50 mg. The third group (C) was given tramadol hydrochloride capsule 100 mg. All of the 300 participants included completed the study voluntarily. The age of the patients varied from 25 to 50 years. After the treatment period, the recorded data were collected for each group and analysed. The results showed a highly significant increase in the mean intravaginal ejaculatory latency time (IELT) in all groups compared to baseline data (P,0.0001). We concluded that using tramadol hydrochloride at different doses on demand for the treatment of PE is effective, safe and tolerable, with minimal undesirable effects, and approval for this indication should be sought.

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A Double-Blind Trial of Clomipramine in Premature Ejaculation

Cited by 68 publications

References 4 publications

A Novel Treatment Modality in Patients With Premature Ejaculation Resistant to Conventional Methods: The Neuromodulation of Dorsal Penile Nerves by Pulsed Radiofrequency

A Novel Treatment Modality in Patients With Premature Ejaculation Resistant to Conventional Methods: The Neuromodulation of Dorsal Penile Nerves by Pulsed Radiofrequency

The role of local anaesthetics in premature ejaculation

Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation

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