A Double‐blind Study on the Influence of Tranexamic Acid on the Intraocular Pressure and the Central Corneal Thickness After Trabeculectomy for Glaucoma Simplex

Self Cite

In 172 patients the thickness of the corneal graft was followed with frequent measurements during the first 14 days after operation. Three different graft thickness time courses were observed. Patients with keratitis, stromal dystrophy and corrosion or mechanical lesion showed a secondary rise in graft thickness on the 6th postoperative day, while patients with keratoconus and those treated with tranexamic acid showed no rise on the 6th day. Patients with Fuchs' dystrophy differed from the other groups in not reaching the maximal thickness until the 3rd postoperative day. The possible correlation of these three time courses with changes in the fibrinolytic system is discussed.

mentioning

confidence: 99%

EARLY POSTOPERATIVE CHANGES IN GRAFT THICKNESS AFTER PENETRATING KERATOPLASTY: Influence of Host Corneal Disorder on Time Course

Bramsen¹,

Ehlers²

1979

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“…The purpose of the present investigation has been to estimate the ocular function of such patients in an attempt to demonstrate any possible toxic damages. The investigation has a special ophthalmological interest as tranexamic acid is used in the treatment of hyphaema (Bramsen 1980) and of certain types of corneal oedema (Bramsen & Ehlers 1977;Bramsen et al 1978;Bramsen 1978) and in patients with Fuchs' endothelial dystrophy also for long periods of time.…”

mentioning

confidence: 99%

Ophthalmological Examination of Patients in Long‐term Treatment With Tranexamic Acid

Theil

1981

Fourteen patients with hereditary angioneurotic oedema (Quincke' oedema) treated for an average period of 6 years (ranging from 15 months to 8 years) with tranexamic acid were given an ophthalmological examination in order to reveal any possible toxic damages caused by the treatment. As large doses of tranexamic acid given to animals have been shown to result in retinal degeneration, the examination was focused on checking the retinal function. A complete ophthalmic examination revealed no toxic effects in the eyes of any of the patients. No retinal damages were found that could have been caused by the tranexamic acid. The central corneal thickness was normal.

“…Antifibrinolytic treatment has been shown to reduce corneal oedema (Bramsen & Ehlers 1977;Bramsen et al 1978;Bramsen 1978) while activation of fibrinolysis in patients with vitreous haemorrhages induces corneal oedema (Bramsen 1978a).…”

mentioning

confidence: 99%

Influence of Tranexamic Acid and Acetylsalicylic Acid on the Thickness of the Normal Cornea

Olsen

Ehlers

Bramsen

1980

Self Cite

In a masked cross-over study ten normal subjects were treated with tranexamic acid and acetylsalicylic acid one g three times daily for seven days. The central corneal thickness. was found to increase in response to acetylsalicylic acid and to decrease in response to tranexamic acid. This finding provides evidence for the involvement of the fibrinolytic system in the regulation of the normal corneal thickness. The endothelial morphology, as seen with the specular microscope, was unchanged during treatment with either drug.