A Double-Blind Study of the Effect of Carbenoxolone Sodium in the Treatment of Gastric Ulcer

A Comparison of Carbenoxolone Sodium and Deglycyrrhizinated Liquorice in the Treatment of Gastric Ulcer in the Ambulant Patient

“…It is now 10 years since carbenoxolone sodium was first shown, by a controlled clinical trial, to promote gastric ulcer healing in the ｾ ｭ ｢ ｵ ｬ ｡ ｮ ｴ patient (Doll et al, 1962). This find-Ing has since been confirmed by a number of Workers (Doll, Hill and Hutton, 1965;Doll, Langman and Shawdon, 1968;Cocking and MacCaig, 1968;Montgomery, Mehta and Lawrence, 1969;Geismar and Mosbech, 1970), but the incidence of side-effects prompted a reduction in the dose initially recommended. This drug is synthesized from glycyrrhetinic acid, the aglycone of glycyrrhizic acid, which is obtained from liquorice root.…”