A Double-Blind Study of the Effect of Imipramine on Enuresis in 100 Naval Recruits

Hicks, W. R.; Barnes, Ellen

doi:10.1176/ajp.120.8.812

Cited by 21 publications

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“…Four of these unsuccessful studies (la, 14,3,19) included subjects over seventeen and as old as sixty-seven. In addition these studies used a dose of 25 or 50 mg. Fifty mg. has been given safely to children under five and it has been suggested by at least one author (39) that adults be treated with 100 mg. to 600 mg.…”

Section: Discussionmentioning

confidence: 99%

“…Noack (32) studied forty-four children and Poussaint and Ditman (34) studied fifty-four children (ages 5-16) and both found imipramine statistically superior to placebos in treating enuretic symptoms. On the negative side, Treffert (40), in double-blind study, found nine patients aged 6-18 did not do better on imipramine than placebos; Blackman and Benton (3) studied thirty-five army recruits (ages [17][18][19][20][21][22][23][24][25] and with a dose of 50 mg. reported imipramine was no more effective than a placebo or no medication; and Hicks and Barnes (19) studied 100 naval recruits in a double-blind study and found no difference between imipramine and placebo. The dose in this latter study was 25 mg. which prompted a letter from Leon Tee, M.D.…”

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The Use of Imipramine in the Treatment of Enuresis a Review of the Literature

Dinello

Champelli

1968

Canadian Psychiatric Association Journal

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

The Use of Imipramine in the Treatment of Enuresis a Review of the Literature

Dinello

Champelli

1968

Canadian Psychiatric Association Journal

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Imipramine (Tofranil) In the Control of Enuresis

Epstein¹

1965

Arch Pediatr Adolesc Med

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Imipramine Pamoate in the Treatment of Childhood Enuresis

Martin¹

1971

Am J Dis Child

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Imipramine pamoate suspension was administered orally to 57 healthy children in a double-blind crossover design study with dosage sequence randomized to determine whether 10 or 25 mg daily would be more effective in controlling nocturnal enuresis, when compared to treatment with a placebo. Both dosage levels of imipramine produced a statistically significant decrease in the number of wet nights when compared to placebo therapy (P<0.01). After the double-blind trial, imipramine treatment was continued in 18 patients at several dosage levels for three months. After discontinuing therapy, there was significantly fewer wet nights than during the final period of drug treatment. Complete monitoring of several laboratory determinations revealed no significant abnormalities at dosages employed. A unified concept concerning the action of imipramine in enuresis, with emphasis on micturition, maturation of neural pathways, and the level of sleep is discussed.Si nce the first observation by MacLean1 on the application of imipramine hydrochloride (Tofranil) in the management of enuresis, over 100 investigations have appeared on the subject. Statistical evaluation of well controlled investigations show that imipramine is superior to pla¬ cebo in decreasing wetting frequen¬ cy. Uncertainty still exists con¬ cerning the drug's proper dosage, length of administration, and meth¬ od of drug withdrawal. Accordingly, imipramine in the pa¬ moate suspension was administered to 57 healthy children in a doubleblind controlled trial to determine the appropriate dosage level in con¬ trolling nocturnal enuresis. In the second part of the investigation, the continuing effect of the pamoate sus¬ pension in various dosage levels was

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A Double-Blind Study of the Effect of Imipramine on Enuresis in 100 Naval Recruits

Cited by 21 publications

References 1 publication

The Use of Imipramine in the Treatment of Enuresis a Review of the Literature

The Use of Imipramine in the Treatment of Enuresis a Review of the Literature

Imipramine (Tofranil) In the Control of Enuresis

Imipramine Pamoate in the Treatment of Childhood Enuresis

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