“…Volunteers were then monitored for signs of hemodynamic compromise over 30 min and, if stable, the remainder of the intravenous dose was administered over a further 30 min. Blood was drawn for measurements of IgE and CGP 51901 levels as well as immune and biochemical parameters after 30 min, 1, 2, 4, 6, 8, and 24 h and then at 5,8,11,15,22,29,43, 57 d and 3 mo after dosing. Volunteers were then seen at monthly intervals to monitor recovery of IgE levels.…”