A double-blind study of the comparative incidence of malignancy and allergy

The common cold, allergy, and cancer

“…For this reason we wished to include questions additional to those concerning colds in the questionnaire. History of allergy seemed a good choice for inclusion because of the contradictory results obtained from earlier studies (Logan & Saker, 1955;Fisherman, 1960;Mackay, 1966;McKee et al, 1967;Ure, 1969;Shapiro et al, 1971;Gabriel et al, 1972;Meers, 1973;Alderson, 1974;Polednak, 1975;Allegra et al, 1976;Robinette & Fraumeni, 1978 analyses were repeated for the subset of cases and controls interviewed within 3 months of first diagnosis (81 cases and 145 controls); the results were similar to those reported in Table III. The relative risk of 6 found by Remy et al (1983) contrasts with our relative risk of 1.4.…”

“…The information in all but one of these studies was obtained (as in ours) by personal interview. Only two studies (McKee et al, 1967;Shapiro et al, 1971) fulfilled the essential requirements that the information should be collected 'blind' and under identical conditions for cases and controls, and that the age distributions of cases and controls should be similar. Neither of these studies find any relationship between allergy and cancer.…”

The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: efficacy, safety, and pharmacokinetics.

“…Volunteers were then monitored for signs of hemodynamic compromise over 30 min and, if stable, the remainder of the intravenous dose was administered over a further 30 min. Blood was drawn for measurements of IgE and CGP 51901 levels as well as immune and biochemical parameters after 30 min, 1, 2, 4, 6, 8, and 24 h and then at 5,8,11,15,22,29,43, 57 d and 3 mo after dosing. Volunteers were then seen at monthly intervals to monitor recovery of IgE levels.…”

Decreased blood histamine levels in patients with solid malignant tumours

“…High levels (Arbesman et al, 1973;Ford, 1978;Hallgren et al, 1981;Blondal & Nou, 1981), normal levels (Serrou et al, 1975;Pauwels & Van Der Straeten, 1975), or low values (Augustin & Chandradasa, 1971;Jacobs et al, 1972) have been found. Questionable criteria for atopy might perhaps explain why some authors do not endorse the negative association between atopy and malignant disease (Logan & Saker, 1953;McKee et al, 1967;Hugues & Raitz, 1979).…”