A double-blind study of the effects of bacterial vaccine on infective asthma

Allergic asthma in childhood.

“…Skin testing with bacterial extracts is generally regarded as of no value (Barr et al, 1965;Wilken-Jensen, 1959). Better evidence is provided when an injection of a bacterial extract leads to an asthmatic reaction, though this may also be due to other factors, such as extraneous allergens in the bacterial vaccine (Aas, 1963).…”

“…Wellcontrolled investigations have failed to support the empirical idea of treating asthma with bacterial extracts, a placebo having proved equally effective (Aas et al, 1963;Fontana et al, 1965;Frankland, Hughes, and Gorrill, 1955;Helander, 1959;Johnstone, 1959;Weil, 1960), except in one study (Barr et al, 1965).…”

The Release of Histamine From Blood Corpuscles by Antigen‐antibody Reactions

“…No effect of the vaccine treatment was observed. There are contradicting reports in the literature as to the effecti\'en€ss of vaccines in the reduction of the symptoms in asthma (i, 2,6,7,8,9). As previously, we were ahle to show that injections of staphylococcus vaccine given to the allergic degrees of freedom »>o.o5 probability us^ed for mrai^uring ^ig^ificancc patients improved their condition.…”

Purification of specific precipitinogen and extraction of endotoxin from Haemophilus influenzae.

“…Gram-negative bacteria are commonly used in skin and bronchial provocation tests (Barr et al, 1965;Brown, 1934;Haj6s, 1963;Haj6s and Hajds, 1964;Herxheimer, 1951;Hirdes, 1969;Ricci et al, 1967). Seemingly, however, no thought was given to the possibility that the reaction could be due to endotoxin rather than an antibody-antigen mediated reaction.…”