A double blind study comparing two dosages of enoxacin for the treatment of uncomplicated urogenital gonorrhoea

Abstract

A double blind pilot study was done to compare the efficacy and safety of treatment of uncomplicated gonorrhoea with two dosages of enoxacin. Eleven patients were treated with 600 mg enoxacin as a single oral dose and eleven patients were given 400 mg twice with an interval of 4 h. A cure rate of 100% was found with both dosages. No side effects were noted and there were no abnormalities in haematological tests or renal and hepatic function tests after treatment. MIC's of enoxacin and other relevant antibiotics were determined. A single oral dose of 600 mg enoxacin seems sufficient to cure uncomplicated gonorrhoea and warrants further investigation in more patients.

Treatment of genitourinary tract infections with fluoroquinolones: clinical efficacy in genital infections and adverse effects

“…Other open or comparative studies with single doses of norfloxacin (800 mg) (9, 44), ciprofloxacin (100 to 500 mg) (30,48,56), ofloxacin (200 to 600 mg) (3,14,33,42), enoxacin (200 to 600 mg) (4,38,50,55,60), or fleroxacin (400 mg) (8) confirmed the efficacy of fluoroquinolones in the treatment of uncomplicated gonorrhea. Treatment failures for gonococcal urethritis or cervicitis have been rare with these agents, except for patients treated with lower doses of enoxacin.…”

“…Infections caused by penicillinase-producing N. gonorrhoeae strains (3,4,9,11,15,27,30,38,39,46,48,50,55,56,60) and strains with chromosomally mediated resistance to penicillin (11) responded similarly to those caused by penicillin-susceptible strains.…”

“…None of the currently available antimicrobial agents, including fluoroquinolones, is effective as a single dose in eradicating C. trachomatis genital infections, which most often occur as the syndrome of nongonococcal urethritis (NGU) or mucopurulent cervicitis. Studies which used single doses of norfloxacin (44), ciprofloxacin (30,43,48), ofloxacin (6,42), enoxacin (55,60), or fleroxacin (29) for the treatment of gonorrhea uniformly reported the substantial persistence of C. trachomatis or the development of postgonococcal urethritis (3,9,38,46,56), which is often caused by C. trachomatis.…”

Norfloxacin versus thiamphenicol for treatment of uncomplicated gonorrhea in Rwanda

“…Thiamphenicol is inexpensive and can be given as a single oral dose. Much research has been done on its toxicity and efficacy in the treatment of uncomplicated gonorrhea (11), with failures being correlated with MICs of -1 ,ug/ml (4,6,8,12).…”

“…It shows very high in vitro activity against N. gonorrhoeae (3,9) and has been used with success in uncomplicated gonorrhea (1), like other newer quinolones (2,6,7,10). In vitro resistance to this group of antibiotics has not been reported until now.…”