A Double-Blind, Randomized Trial of the Efficacy and Safety of Short-Course, Once-Daily Levofloxacin Versus Ofloxacin Twice Daily in Uncomplicated Urinary Tract Infections

Richard, George A.; DeAbate, C. Andrew; Ruoff, Gary; Corrado, Michael L.; Fowler, Cynthia; Morgan, Nancy

doi:10.1097/00019048-200009080-00006

Cited by 14 publications

(8 citation statements)

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“…In uncomplicated acute lower UTI, short-course three-day therapy with cefuroxime axetil or levofloxacin antibiotics is found to be effective, as shown by various studies. (13) The results of our study show that E.coli was the most common pathogen isolated, similar to the findings seen in other studies. (2,4,5) Also, cefuroxime axetil in a dose of 250 mg twice daily and levofloxacin 500 mg once daily were found to be equally efficacious in treating patients with uncomplicated lower UTI.…”

Section: Discussionsupporting

confidence: 92%

“…Our study showed similar response to levofloxacin, although the dose of levofloxacin used in this study was 500 mg od, as compared to 250 mg od in the previous study. (13) In a study by Lee et al in 2011, the susceptibility of E.coli to levofloxacin was 77.5 percent. (22) The current study shows the effect of cefuroxime axetil was also quite similar to that seen in previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…amoxicillin, trimethoprim-sulphamethoxazole (TMP-SMX). (5,11,12,13) The drug levofloxacin is well-absorbed, its bioavailability approaches 100 percent, and it is widely distributed throughout the body. (14) The drug is well-tolerated with a low incidence of resistance.…”

Section: Introductionmentioning

confidence: 99%

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A Study to Compare the Safety and Efficacy of Levofloxacin Versus Cefuroxime Axetil in Patients with Uncomplicated Lower UTI in a North Indian Medical College and Hospital

Garg¹,

Singh²,

Walia³

2014

MEJIM

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Background and Objectives: Uncomplicated lower UTI accounts for around 150 million cases worldwide, every year. Antibiotics commonly used for the treatment of uncomplicated lower UTI include fluoroquinolones, trimethoprim-sulphamethoxazole, nitrofurantoin, cephalosporins, and amoxicillin. No comparative study between levofloxacin and cefuroxime axetil in patients with uncomplicated lower UTI could be searched. So, this randomized study was designed to compare the efficacy and tolerability of levofloxacin 500 mg once daily with cefuroxime axetil 250 mg twice daily in the treatment of uncomplicated lower UTI in adult Indian patients. Methods: This prospective, parallel group comparative study was conducted in 100 patients with uncomplicated lower UTI. Patients were assessed for clinical and bacteriological success over the study period. Results: 89 patients of the total of 100 patients enrolled in the study completed the study. E.coli was the most common organism isolated in both the groups. Patients in levofloxacin group showed improvement in clinical symptoms by 95.35 percent, as compared to 89.13 percent in the cefuroxime group. However, the intergroup difference was not statistically significant (p>0.05). Levofloxacin group showed decrease in bacteriological scoring by 95.35 percent, and cefuroxime group showed decrease by 86.96 percent. The difference in bacteriological scoring between the two treatment groups was not significant (p>0.05). Conclusion: The results of our study show that cefuroxime axetil in a dose of 250 mg twice daily and levofloxacin 500 mg once daily for three days, are equally efficacious in treating patients with uncomplicated lower UTI. The comparative clinical and bacteriological successes between the two groups were statistically not significant, and both drugs were well-tolerated by the patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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A Study to Compare the Safety and Efficacy of Levofloxacin Versus Cefuroxime Axetil in Patients with Uncomplicated Lower UTI in a North Indian Medical College and Hospital

Garg¹,

Singh²,

Walia³

2014

MEJIM

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“…According to a Cochrane analysis [4] all fluoroquinolones suitable for the treatment of UTI showed the same effectiveness for this indication, but the tolerability differed. Levofloxacin, for example, is used as 250 mg qd for 3 days and is as effective as ofloxacin 200 mg bid for 3 days, but has better tolerance [32].…”

Section: Fluoroquinolonesmentioning

confidence: 99%

Antibiotic treatment of uncomplicated urinary tract infection in premenopausal women

Naber

Wullt

Wagenlehner

2011

International Journal of Antimicrobial Agents

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“…Levofloxacin is a fluoroquinolone antibacterial with substantial activity against Gram‐negative and Gram‐positive aerobic microorganisms, atypical pathogens, and some anaerobes (1–9). Levofloxacin has proven to be useful in the treatment of a wide variety of infections, including community‐acquired pneumonia (10, 11), acute exacerbation of chronic bronchitis (12, 13), acute maxillary sinusitis (14–17), uncomplicated skin and skin‐structure infections (SSSIs) (18, 19), uncomplicated urinary tract infections (20), complicated urinary tract infections (21, 22), and acute pyelonephritis (23). In patients with normal renal function, levofloxacin is administered at 500 mg doses once‐daily for respiratory and uncomplicated skin infections, and at 250 mg doses once‐daily for urinary tract infections (24).…”

Section: Introductionmentioning

confidence: 99%

Penetration of levofloxacin into skin tissue after oral administration of multiple 750 mg once-daily doses

et al. 2002

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A Double-Blind, Randomized Trial of the Efficacy and Safety of Short-Course, Once-Daily Levofloxacin Versus Ofloxacin Twice Daily in Uncomplicated Urinary Tract Infections

Cited by 14 publications

References 0 publications

A Study to Compare the Safety and Efficacy of Levofloxacin Versus Cefuroxime Axetil in Patients with Uncomplicated Lower UTI in a North Indian Medical College and Hospital

A Study to Compare the Safety and Efficacy of Levofloxacin Versus Cefuroxime Axetil in Patients with Uncomplicated Lower UTI in a North Indian Medical College and Hospital

Antibiotic treatment of uncomplicated urinary tract infection in premenopausal women

Penetration of levofloxacin into skin tissue after oral administration of multiple 750 mg once-daily doses

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