A double‐blind randomized study comparing the association of Retinol and LR2412 with tretinoin 0.025% in photoaged skin

Abstract

Introduction Topical tretinoin is considered the gold standard to treat photoaged skin, but it is associated with side effects and only available upon prescription. Aim of the study To compare the efficacy, tolerance, and perception of a fixed proprietary combination (Retinol 0.2%/LR2412 2%) vs. tretinoin 0.025% cream in women with photoaged skin. Material/Methods In this randomized, parallel, double-blind, controlled clinical study, women applied to the entire face for 3 months in the morning a SPF 50 sunscreen and in the evening either the association of Retinol 0.2%/LR2412 2% or tretinoin 0.025%. Clinical and instrumental parameters were assessed at days 0, 28, 56, and 84. Subject perception of the efficacy, tolerance and cosmeticity of the tested products were assessed at days 28, 56, and 84. Results A total of 120 women (60 to Retinol 0.2%/LR2412 2% cream and 60 to tretinoin 0.025% cream) were included in the study. Both products improved considerably wrinkles, mottled pigmentation, pores, and global photodamage. No statistically significant differences were noted between Retinol 0.2%/LR2412 2% cream and tretinoin 0.025% cream. Adverse effects were mostly graded mild. Overall, Retinol 0.2%/LR2412 2% cream was better tolerated than tretinoin 0.025% cream. At all visits, subject perception of the association of Retinol 0.2%/LR2412 2% was either comparable to or better than tretinoin 0.025% cream. Conclusion The treatment outcome of Retinol 0.2%/LR2412 2% cream does not differ from the one of tretinoin 0.025% cream. Clinical results were not statistically different. Furthermore, Retinol 0.2%/LR2412 2% cream is better tolerated and better perceived by women used to rejuvenation procedures.

A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skin

“…Enhanced collagen synthesis is a contributing factor for improved and younger looking skin, in part, through wrinkle reduction . A recent study showed that the clinical outcome following retinol treatment did not differ from one using retinoic acid to treat photoaging . The results from our clinical study show similar effects following 12‐weeks of retinol treatment as demonstrated by significant wrinkle reduction.…”

A blinded study assessment of the efficacy of an original formula with retinol in combination with sonophoresis

“…Both products yielded reduced skin changes and discoloration, and resulted in a general improvement of skin condition by inhibiting photoaging. No differences were noticed between them, except that the cream with retinol was better tolerated by the skin (Bouloc & Vergnanini, 2014).…”

“…No differences were noticed between them, except that the cream with retinol was better tolerated by the skin (Bouloc & Vergnanini, 2014). For 3 months, the study participants applied a cream consisting of a proprietary combination of 0.2% retinol with 0.025% tretinoin at night, and then SPF-50 sunscreen during the day.…”

Antiaging efficacy of a retinaldehyde‐based cream compared with glycolic acid peel sessions: A randomized controlled study

“…Many retinoid‐based regimens have been compared alone, or in combination with other compounds . Novel retinol formulations have also been the focus of attention .…”