A double-blind randomized study comparing intramuscular (i.m.) granisetron with i.m. granisetron plus dexamethasone in the prevention of delayed emesis induced by cisplatin

We performed a systematic review of the eŠectiveness of anti-emetics for prophylaxis of cisplatin-induced delayed emesis using meta-analysis. We selected 12 reports of randomized controlled trials from MEDLINE (1966 2003 and The Cochrane Library Issue 1, 2003. Nine of these reports were evaluated as high quality and the others as low quality according to the evaluation criteria of Jadad et al., and only the high-quality reports were subjected to meta-analysis. The statistical results obtained from all 12 reports were also compared with those obtained from the 9 reports of high quality. Corticosteroids signiˆcantly reduced the occurrence of delayed emesis. Metoclopramide tended to reduce the occurrence of delayed emesis, although not to a signiˆcant extent. In contrast, 5-HT 3 receptor antagonists did not show a signiˆcant prophylactic eŠect on delayed emesis. Combination treatments using corticosteroids with metoclopramide or 5-HT 3 receptor antagonists did not show signiˆcant additional beneˆts over corticosteroids alone. In conclusion, treatment with corticosteroids without additional metoclopramide or 5-HT 3 receptor antagonists appears to be preferable for the prevention of delayed emesis induced by cisplatin.

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A double-blind randomized study comparing intramuscular (i.m.) granisetron with i.m. granisetron plus dexamethasone in the prevention of delayed emesis induced by cisplatin

Cited by 4 publications

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Effectiveness of palonosetron versus granisetron in preventing chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis

Effectiveness of palonosetron versus granisetron in preventing chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis

Comparative activity of antiemetic drugs

Effectiveness of Anti-emetics for the Prophylaxis of Cisplatin-Induced Delayed Emesis : A Systematic Review

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