A Double-Blind, Randomized, Saline-Controlled Study of the Efficacy and Safety of EUFLEXXA® for Treatment of Painful Osteoarthritis of the Knee, With an Open-Label Safety Extension (The FLEXX Trial)

Altman, Roy D.; Rosen, Jeffrey; Blöch, D.; Hatoum, Hind T.; Korner, Paul I.

doi:10.1016/j.semarthrit.2009.04.001

Cited by 113 publications

(116 citation statements)

References 28 publications

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“…3,9,53 Rates of cardiovascular and gastrointestinal (GI) side effects with VS are also similar to those observed with controls. 27 Additionally, the incidence of GI side effects is lower with VS plus conventional therapy than with conventional therapy alone.…”

Section: Efficacy and Safety In Knee Osteoarthiritissupporting

confidence: 55%

“…1-3,9,13,17,19,21,22,28,31,34,35,41,44,46,50,53,57,66 Pain improved from 28% to 54% and function from 9% to 32% at 5 to 13 weeks postinjection compared with baseline. 8 The most recent review found a moderate benefit of VS for pain reduction (effect size [ES], −0.37; 95% CI, 0.46 to −0.28) compared with placebo or no intervention.…”

Section: Efficacy and Safety In Knee Osteoarthiritismentioning

confidence: 94%

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Viscosupplementation During Rehabilitation

Silvers

2014

Sports Health

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Context:Viscosupplementation (VS) and physical therapy are both used to treat pain associated with knee osteoarthritis (OA).Evidence Acquisition:PubMed and EMBASE searches were performed to July 2013. Search terms included hyaluronic acid OR hylan, physical therapy OR exercise, AND osteoarthritis.Study Design:Clinical review.Level of Evidence:Level 4.Results:The efficacy and safety of VS in painful knee OA is well documented, as are the appropriate candidates for this intervention. Studies suggest that adding VS to physical therapy and therapeutic exercise may lead to improved pain reduction and increased functionality compared with physical therapy alone.Conclusion:Appropriately selected patients undergoing physical therapy for knee OA may benefit from VS.

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Section: Efficacy and Safety In Knee Osteoarthiritissupporting

confidence: 55%

Section: Efficacy and Safety In Knee Osteoarthiritismentioning

confidence: 94%

Viscosupplementation During Rehabilitation

Silvers

2014

Sports Health

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“…31 A closer examination of this review from 2012 revealed that the most recent meta-analysis quoted in this article was published in 2009, and there were 7 trials published outside of this metaanalysis. [32][33][34][35][36][37][38] The American Academy of Orthopedic Surgeons recently published a meta-analysis that included all those recent trials. Unlike other systematic reviews, they excluded those studies that recruited fewer than 30 patients in each treatment group and included only those trials that demonstrated clinical efficacy beyond 4-week treatment period.…”

Section: Efficacy Of Ia Knee Injectionsmentioning

confidence: 99%

Ultrasound-Guided Interventional Procedures in Pain Medicine

Peng

Shankar

2014

Regional Anesthesia and Pain Medicine

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Ultrasound-guided injection in pain medicine is emerging as a popular technique for pain intervention. It can be applied to the intra-articular injection of the knee joint. The first objective of this review was to describe and summarize the anatomy and sonoanatomy of the knee and associated structures relevant for intra-articular injection. The second objective was to examine the feasibility, accuracy, and effectiveness of injections as well as injection techniques.

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“…Several clinical trials have been conducted in recent years proposing hyaluronic acid preparations as potential treatments for relieving pain in OA. A number of formulations have been subjected to clinical trials, including hylan and hyaluronic acid derivatives [58][59][60]. Most of the clinical trials have been conducted in subjects with established painful knee OA.…”

Section: Hyaluronic Acid Preparationsmentioning

confidence: 99%

“…More recent studies have included placebo arms e.g. with saline treatment to show that the analgesic effect is greater in the hyaluronan treated group [60]. More recent trials have compared hyaluronan head-tohead with corticosteroids to obtain good therapeutic effect [61].…”

Section: Hyaluronic Acid Preparationsmentioning

confidence: 99%

Recent Clinical Evidence for the Treatment of Osteoarthritis: What we have Learned

Sofat

Beith²,

Anilkumar³

et al. 2011

RRCT

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Osteoarthritis (OA) is a chronic arthritis affecting growing numbers of the ageing population. Patients diagnosed with OA place a large burden on access to healthcare services, including primary care, prescription of analgesic drugs, physiotherapy and joint replacement surgery. Not all patients diagnosed with OA will require joint replacement surgery, and therefore avenues for non-surgical treatment for such patients need to be explored in many cases. In this review we discuss current concepts underlying the pathophysiology of OA. These form a basis to understanding the rationale for new and existing therapies based on recent evidence available from clinical studies and trials in OA. In particular, we discuss the evidence for use of pharmacological treatments, including NSAIDs (non-steroidal anti-inflammatory drugs), chondroitin sulphate and glucosamine, hyaluronan, potential disease-modifying drugs and other interventions such as weight reduction and physiotherapy. Finally, we discuss new developments from clinical evidence for surgical options, including ACL repair surgery and joint replacement surgery.

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A Double-Blind, Randomized, Saline-Controlled Study of the Efficacy and Safety of EUFLEXXA® for Treatment of Painful Osteoarthritis of the Knee, With an Open-Label Safety Extension (The FLEXX Trial)

Cited by 113 publications

References 28 publications

Viscosupplementation During Rehabilitation

Viscosupplementation During Rehabilitation

Ultrasound-Guided Interventional Procedures in Pain Medicine

Recent Clinical Evidence for the Treatment of Osteoarthritis: What we have Learned

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