A Double‐Blind, Randomized, Placebo‐Controlled Trial of Macrolide in the Treatment of Chronic Rhinosinusitis

Wallwork, Ben; Coman, William B.; Mackay‐Sim, Alan; Greiff, Lennart; Cervin, Anders

doi:10.1097/01.mlg.0000191560.53555.08

Cited by 301 publications

(316 citation statements)

References 16 publications

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“…For example, a prospective open-label study of 17 patients with persistent sinusitis following sinus surgery, using erythromycin treatment, showed significant improvements in saccharin transit time and symptoms, including nasal congestion, rhinitis and headache, at 3 and 12 months of follow-up [41]. The first double-blind randomised placebo-controlled study examining the effects of low-dose macrolide therapy in chronic rhinosinusitis was reported in 2006 [43]. This study investigated the effects of 3 months' roxithromycin treatment in 64 patients with chronic rhinosinusitis.…”

Section: Chronic Rhinosinusitismentioning

confidence: 99%

Long-term macrolide therapy in chronic inflammatory airway diseases

Crosbie¹,

Woodhead²

2009

European Respiratory Journal

119

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In addition to direct antibacterial actions, 14-and 15-member-ring macrolides have immune modulating effects that appear to be the reason for clinical benefit in diffuse panbronchiolitis.A literature search was conducted for studies of the clinical effectiveness of macrolides in other chronic lung conditions.A number of studies were identified that showed short-term beneficial outcomes or the potential for such outcomes in cystic fibrosis, bronchiectasis, chronic obstructive pulmonary disease, asthma and post-transplant obliterative bronchiolitis. The studies were limited by small patient numbers, different outcome measures and short-term follow-up, and were not designed to assess potentially harmful effects.Further large prospective and long-term studies are required in order to identify potential benefit and harm before these agents can be recommended routinely for these conditions.

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Section: Chronic Rhinosinusitismentioning

confidence: 99%

Long-term macrolide therapy in chronic inflammatory airway diseases

Crosbie¹,

Woodhead²

2009

European Respiratory Journal

119

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“…It is a good alternative to Erythromycin for respiratory, aural, pharyngeal, nasal, skin, soft tissue and genital infections 5 . Apart from antibacterial activity, macrolides are documented to have anti-inflammatory actions, and the same has been documented in animal models 6 , as well as in clinical scenarios [7][8][9] .The anti-inflammatory activity of Roxithromycin and erythromycin are proposed to be independent of Cyclo-Oxygenase-2 (COX 2) inhibition 6 .…”

Section: Introductionmentioning

confidence: 99%

Analgesic and Anti-inflammatory Activity of Roxithromycin and Erythromycin, Alone and in Combination with Ibuprofen: An Animal Study

Khobragade¹

2011

iosrphr

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Background: Several in-vitro, animal and clinical studies have reported anti-inflammatory activity of macrolides. Antiinflammatory properties of macrolides form the basis for their experimental use in airway inflammatory and infective conditions like asthma Materials and Method: After animal ethics committee approval, the anti-inflammatory and analgesic potentials of erythromycin (40 mg/kg) and roxithromycin (20 mg/kg) were evaluated in carrageenan-induced rat paw edema model and rat tail flick model respectively, in comparison and combination with ibuprofen (100 mg/kg) in albino wistar rats. Results and Interpretation: Both the macrolides were found to have significant anti-inflammatory activity, roxithromycin being slightly more efficacious than erythromycin. Combination with ibuprofen failed to produce improved benefit. Both the macrolides neither showed significant analgesic property alone, nor enhanced analgesic effect of ibuprofen significantly. Conclusion:The macrolides have shown anti-inflammatory activity and a tendency towards analgesic potential; possible mechanisms are discussed. Further studies are required before any recommendations can be made.

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“…В последнее время в мировой литературе появился ряд исследований, свидетельствующих о положительном эффек-те терапии ХР длительным курсом макролидных анти-биотиков [27,28]. Это связано не только с антибактериаль-ным эффектом этой группы препаратов, но и с их противо-воспалительным и иммуномодулирующим действием.…”

Section: хронический риносинусит (хр)unclassified

Antibacterial Therapy for Acute and Chronic Diseases of the Upper Respiratory Tract in Adults

Дербенева¹

2017

Medicinskij sovet

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В статье представлены наиболее часто встречающиеся заболевания верхних дыхательных путей у взрослых, дифферен-циально-диагностические критерии острой респираторной вирусной инфекции, острого тонзиллофарингита, острого и хронического риносинусита. Обсуждаются необходимость, сроки назначения антибактериальной терапии, а также группы антибиотиков и их дозировки при этих заболеваниях.

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A Double‐Blind, Randomized, Placebo‐Controlled Trial of Macrolide in the Treatment of Chronic Rhinosinusitis

Cited by 301 publications

References 16 publications

Long-term macrolide therapy in chronic inflammatory airway diseases

Long-term macrolide therapy in chronic inflammatory airway diseases

Analgesic and Anti-inflammatory Activity of Roxithromycin and Erythromycin, Alone and in Combination with Ibuprofen: An Animal Study

Antibacterial Therapy for Acute and Chronic Diseases of the Upper Respiratory Tract in Adults

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