A double-blind randomized placebo-controlled trial of probiotics in systemic sclerosis associated gastrointestinal disease

Low, Andrea; Teng, Gim Gee; Pettersson, Sven; Sessions, Paola Flórez de; Ho, Eliza Xin Pei; Fan, Qiao; Chu, Collins Wenhan; Law, Annie; Santosa, Amelia; Lim, Andrew Kean Seng; Wang, Yu Tien; Haaland, Benjamin; Thumboo, Julian

doi:10.1016/j.semarthrit.2019.05.006

Cited by 35 publications

(19 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Significant findings have been evidenced in another trial, where the efficacy of probiotics in systemic sclerosis-associated gastrointestinal disease was positively evaluated regarding gastrointestinal reflux. The SSc clinical outcomes were not, however, evaluated in that study [50].…”

Section: Systemic Sclerosis (Ssc)mentioning

confidence: 95%

The Influence of Dietary Intervention in Connective Tissue Diseases: Evidence from Randomized Clinical Trials

et al. 2021

View full text Add to dashboard Cite

The aim of this review is to identify and discuss randomized clinical trials conducted in patients with connective tissue diseases, including systemic lupus erythematosus, idiopathic inflammatory myopathies, vasculitis, Sjögren’s syndrome, and systemic sclerosis. Although limited, the results obtained with bioactive compounds, namely n-3 polyunsaturated and short-chain fatty acids, demonstrate that dietary intervention and nutritional counseling might have an important role as adjuvant therapy in patients with connective tissue diseases, particularly in the light of the comorbidities which characterize these conditions.

show abstract

Section: Systemic Sclerosis (Ssc)mentioning

confidence: 95%

The Influence of Dietary Intervention in Connective Tissue Diseases: Evidence from Randomized Clinical Trials

et al. 2021

View full text Add to dashboard Cite

show abstract

“…One of these has shown that an 8-week probiotics supplementation did not have any effect in reducing gastrointestinal symptoms but lead to a decrease in Th17 cell levels indicating an immunomodulatory capacity of the probiotic strains used ( Table 1) (17). Another trial confirmed the inefficacy of probiotics in systemic sclerosis associated gastrointestinal disease but SSc clinical outcomes were not addressed in that study (30).…”

Section: Other Rheumatic Diseasesmentioning

confidence: 97%

Benefits of Probiotics in Rheumatic Diseases

Oliviero

Spinella

2020

Front. Nutr.

View full text Add to dashboard Cite

Rheumatic diseases are chronic conditions which affect a large proportion of the population worldwide (1). Among them, inflammatory chronic diseases including rheumatoid arthritis (RA), spondyloarthritis (SpA), crystal-induced arthritis (CIA), and connective tissue autoimmune diseases, such as systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), are the most common. Chronic inflammation has been recognized to play a role also in osteoarthritis (OA), classically considered a non-inflammatory form of arthritis. Although different risk factors influence their onset and development, these heterogeneous conditions share common clinical outcome including joint pain, disability, and comorbidities (2). Over the last years increasing attention have been paid to the role of diet in the pathogenesis and progression of rheumatic diseases. It has been observed that healthy dietary habits and the consumption of foods rich in bioactive compounds, omega-3 fatty acids, and antioxidants are associated with a lower risk to develop these diseases and a less severe clinical outcome (3). In particular, an important link between gut microbiota and patients' clinical features highlighted the possibility to modulate disease progression and presentation through microbiota manipulation. In this setting, an emerging role might be attributed to probiotics, live microorganisms that, when administered in adequate amounts, confer a health benefit on the host (4). The most commonly used are Lactobacilli (L.), Bifidobacteria (B.), and Streptococci (S.), either as single species or in mixed culture. Their health effects are largely recognized and supported by randomized controlled clinical trials (RCTs) and meta-analyses conducted on infectious diseases, antibiotic-associated diarrhea, irritable bowel syndrome, abdominal pain, and colitis (5, 6).

show abstract

“…Additionally, it improved GI symptoms and had fewer adverse effects[ 103 ]. In general, after the administration of multistrain probiotics in patients with GI and SSc symptoms, adverse events are mild[ 104 ].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Gastrointestinal manifestations of systemic sclerosis: An updated review

Lúquez-Mindiola

Atuesta

Aldana

2021

WJCC

View full text Add to dashboard Cite

Systemic sclerosis is an autoimmune disease characterized by vascular disease, fibrosis of the skin, and internal organ dysfunction. Gastrointestinal involvement is the most frequent complication of internal organs, impacting up to 90% of patients. Gastrointestinal involvement can affect any region of the gastrointestinal tract from the mouth to the anus, with a predominance of disorders being observed at the level of the upper digestive tract. The gastrointestinal involvement primarily involves the esophagus, small bowel, and rectum. The severity of gastrointestinal involvement affects quality of life and is a marker of worse prognosis and mortality in these patients. In this review, we describe the current findings regarding gastrointestinal involvement by this entity.

show abstract

A double-blind randomized placebo-controlled trial of probiotics in systemic sclerosis associated gastrointestinal disease

Cited by 35 publications

References 33 publications

The Influence of Dietary Intervention in Connective Tissue Diseases: Evidence from Randomized Clinical Trials

The Influence of Dietary Intervention in Connective Tissue Diseases: Evidence from Randomized Clinical Trials

Benefits of Probiotics in Rheumatic Diseases

Gastrointestinal manifestations of systemic sclerosis: An updated review

Contact Info

Product

Resources

About