A Double-blind, Randomized, Placebo-controlled Trial of Lactobacillus acidophilus for the Treatment of Acute Watery Diarrhea in Vietnamese Children

Chau, Tran Thi Hong; Chau, Nguyen Ngoc Minh; Le, Nikitina; Vinh, Phat Voong; To, Nguyen Thi Nguyen; Ngọc, Nguyễn Minh; Tuan, Ha Manh; Ngoc, Tang Le Chau; Kolader, Marion-Eliëtte; Farrar, Jeremy; Wolbers, Marcel; Thwaites, Guy; Baker, Stephen

doi:10.1097/inf.0000000000001712

Cited by 24 publications

(22 citation statements)

References 27 publications

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“…Furthermore, our yogurt contained LF and also lactic bacteria. Habitual yogurt consumption and food intake, including lactic bacteria, have been reported to alleviate gastrointestinal symptoms [30][31][32][33][34][35]. Yogurt containing lactic bacteria without LF might affect intestinal microbiota composition.…”

Section: Discussionmentioning

confidence: 99%

The Preventive Effect of Lactoferrin-Containing Yogurt on Gastroenteritis in Nursery School Children—Intervention Study for 15 Weeks

Tsukahara

Fujimori

Misawa

et al. 2020

IJERPH

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To evaluate the effects of bovine lactoferrin (LF)-containing yogurt on gastroenteritis in nursery school children during the winter season, we conducted a randomized prospective study. A total of 1296 children were randomized into a group in which LF was provided in yogurt (LF group, n = 661) and a non-LF consumption group (control group, n = 635). The LF group was given LF-containing yogurt (100 mg/day) on all 5 weekdays for approximately 15 weeks, and the control group consumed fruit jelly instead of the yogurt. The final totals of 578 children as the LF group and 584 as the control group were analyzed. The total number of children who were absent from school due to vomiting was significantly lower in the LF group compared to the control, accounting for ≥3 days in any week: 10/234 (4.3%) vs. 49/584 (8.4%), respectively; p = 0.04. Regarding the relationship between absences due to vomiting and the consumption of the LF-containing yogurt, the adjusted odds ratio for absence due to vomiting was 2.48 (95% CI: 1. 19-5.14) in the LF children who consumed LF-containing yogurt ≤2 days/week compared to the LF children who consumed the yogurt ≥3 days/week. The consumption of LF-containing yogurt (100 mg/day) for ≥3 days/week might help alleviate the symptom of vomiting in nursery school children during the winter.

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Section: Discussionmentioning

confidence: 99%

The Preventive Effect of Lactoferrin-Containing Yogurt on Gastroenteritis in Nursery School Children—Intervention Study for 15 Weeks

Tsukahara

Fujimori

Misawa

et al. 2020

IJERPH

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“…A study by Sur et al [5] involving children aged 1–5 years in an urban slum in India found that probiotics could help to prevent acute diarrhea. In addition, in an RCT conducted in Vietnam by Hong Chau et al [8], the time to the disappearance of diarrhea was shorter, albeit not significantly, in the group administered probiotics. On the other hand, Hatakka et al [15] found no association between lactobacillus rhamnosus consumption and respiratory infection in children attending daycare centers in Finland.…”

Section: Discussionmentioning

confidence: 99%

“…In a study in Finland of 40 patients with diarrhea, compared with placebo, Lactobacillus reuteri was associated with a smaller proportion of symptomatic patients on day 2 (26% vs 81%, p = 0.0005) and short treatment duration (1.7 days vs 2.9 days, p = 0.07) [7]. However, several randomized controlled trials (RCTs) showed that the frequency of diarrhea was slightly, but not significantly, lower in probiotic groups than in placebo groups [8–10]. As part of a cohort analysis of elderly individuals with proximal femur fractures, Mallina et al [11] reported no preventive effect of a probiotic against Clostridium difficile -associated diarrhea.…”

Section: Introductionmentioning

confidence: 99%

Infant dietary intake of yogurt and cheese and gastroenteritis at 1 year of age: The Japan Environment and Children’s Study

et al. 2019

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BackgroundThe important role played by intestinal bacterial flora in human health has recently attracted public attention worldwide. Although yogurt is thought to help in preventing the onset of gastroenteritis, this property has rarely been examined in epidemiological studies.MethodThis study analyzed data obtained by the Japan Environment and Children’s Study. From a dataset of 103,062 pregnancies, 82,485 were selected for this analysis. Dietary intake of fermented foods (yogurt and cheese) in 1-year-old infants was assessed with a food frequency questionnaire. Parent-reported physician-diagnosed gastroenteritis in early childhood was determined from a questionnaire conducted when the child was 1 year old.ResultThe incidence of gastroenteritis was significantly lower in infants who consumed yogurt ≥ 7 and 3–6 times/week than in infants who consumed yogurt < 1 time/week in crude models (n = 82,485) and after adjustment for covariates (adjusted odds ratio [95% confidence interval], 0.78 [0.70–0.86] versus 0.82 [0.76–0.89], respectively; n = 65,051). Frequency of weekly cheese consumption was not associated with the incidence of gastroenteritis.ConclusionConsumption of yogurt, but not cheese, at 1 year of age was associated with a reduced risk of gastroenteritis. Further studies of this association, including interventional studies, are warranted.

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“…When reported, the standard deviation (SD) was utilized or computed from the median and interquartile range (IQR). In four trials reporting median and IQR [ 10 , 11 , 16 , 17 ], missing means and SDs were estimated using the formula recommended by Wan et al [ 18 ] and McGrath et al [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

“…However, in the light of recent null studies, there is still controversy as to whether the efficacy of Lactobacillus acidophilus has been established. A relatively large, prospective randomized controlled trial (RCT) carried out in Vietnam, including 290 children aged 11.8 months to 21.5 months, compared the operation of Lactobacillus acidophilus , at a dose of 4 × 10 8 CFU twice daily, to a matching placebo, found no differences in outcomes, including duration of diarrhea and stool frequency in the first three days after enrollment, between groups [ 10 ]. Moreover, in several additional randomized controlled trials (RCTs), no difference in diarrhea duration was reported across groups [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review and Meta-Analysis: Lactobacillus acidophilus for Treating Acute Gastroenteritis in Children

Cheng

Liu

et al. 2022

Nutrients

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The efficacy of probiotic strains of Lactobacillus acidophilus to manage acute gastroenteritis in children is still not established. We searched the Cochrane Library, PubMed, EMBASE, and three Chinese literature databases (CNKI, WanFang, and CBM) from their inception to February 2021 for RCTs that compared the use of Lactobacillus acidophilus with no Lactobacillus acidophilus. The grey literature was searched through Google Scholar. Authors of the original papers were contacted for additional data. The study included a total of 15 RCTs involving 1765 patients. Compared with placebo or no treatment, Lactobacillus acidophilus was associated with a reduced duration of diarrhea (moderate quality of evidence), but the effect was not statistically significant when only the individual probiotic strain was provided. Lactobacillus acidophilus was effective when used at a daily dose ≥ 109 CFU. There was no difference in the effect of Lactobacillus acidophilus on diarrhea duration among Asian, European, or American countries. Lactobacillus acidophilus reduced the frequency of diarrhea on day 2 to day 5. However, it was statistically significant on day 3. When administered at a dosage of more than 109 CFU to children with acute gastroenteritis, moderate- to low-quality data showed that Lactobacillus acidophilus reduced the duration of diarrhea and conferred a benefit for frequency of diarrhea.

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A Double-blind, Randomized, Placebo-controlled Trial of Lactobacillus acidophilus for the Treatment of Acute Watery Diarrhea in Vietnamese Children

Abstract: This was a large double-blind, placebo-controlled trial in which the probiotic underwent longitudinal quality control. We found under these conditions that L. acidophilus was not beneficial in treating children with acute watery diarrhea.

Cited by 24 publications

References 27 publications

The Preventive Effect of Lactoferrin-Containing Yogurt on Gastroenteritis in Nursery School Children—Intervention Study for 15 Weeks

The Preventive Effect of Lactoferrin-Containing Yogurt on Gastroenteritis in Nursery School Children—Intervention Study for 15 Weeks

Infant dietary intake of yogurt and cheese and gastroenteritis at 1 year of age: The Japan Environment and Children’s Study

A Systematic Review and Meta-Analysis: Lactobacillus acidophilus for Treating Acute Gastroenteritis in Children

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