A double-blind randomized placebo-controlled trial of topical intranasal mometasone furoate nasal spray in children of adenoidal hypertrophy with otitis media with effusion

Bhargava, Rahul; Chakravarti, Arunabha

doi:10.1016/j.amjoto.2014.06.006

Cited by 43 publications

(29 citation statements)

References 11 publications

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“…Durch Reduktion der Zellproliferation sowie der Produktion proinflammatorischer Zytokine kann die adenotonsilläre Hypertrophie zurückgehen. In einer doppelt verblindeten Studie an Kindern mit adenotonsillärer Hypertrophie und OME zeigte sich ein signifikanter Rückgang der OME mit gleichzeitiger Besserung der Hörleistung in der Gruppe, die über sechs Monate Mometason-Nasenspray angewendet hatte [9].…”

Section: Therapieunclassified

Otitis media – Definition, Pathogenese, Klinik, Diagnose und Therapie

Leichtle¹,

Hoffmann²,

Wigand³

2018

Laryngo-Rhino-Otol

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A number of diseases of the middle ear are summed up under the term otitis media: acute otitis media, recurrent acute otitis media, otitis media with effusion, chronic suppurative otitis media and chronic otitis media epitympanalis (= cholesteatoma). Acute otitis media belongs to the most common pediatric diseases and is often caused by bacterial infection. Since the advent of pneumococcal vaccines the quantity of AOM caused by pneumococci has declined; vaccination against NTHi and Moraxella catarrhalis are being developed. Main pillar of conservative treatment of AOM is symptomatic therapy of otalgia and fever as well as restoring the Eustachian tubal function. When indicated, amoxicillin represents antibiotic medication of choice. Acute mastoiditis, facial nerve paresis, labyrinthitis, Gradenigo syndrome, sinus vein thrombosis, meningitis and brain abscess belong to the complications of AOM among others. Both innate and adaptive immune system are involved in recovery of OM with innate immunity playing a critical role. Dysfunction of the Eustachian tube often underlies OM. Manometric measurement of Eustachian tube function may be useful for indication of balloon Eustachian tuboplasty. Several theories explain pathogenesis of cholesteatoma and multiple pro-inflammatory processes promote its progress in the course of the disease.

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Section: Therapieunclassified

Otitis media – Definition, Pathogenese, Klinik, Diagnose und Therapie

Leichtle¹,

Hoffmann²,

Wigand³

2018

Laryngo-Rhino-Otol

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“…In the past two decades, the use of topical nasal steroids has brought significant improvement for AH patients, and thus many children have avoided adenoidectomy1819202122. In 1995, Demain and Goetz described the first successful use of beclomethasone for AH in paediatric patients with a 29% decrease in the A/C ratio on average5.…”

Section: Discussionmentioning

confidence: 99%

Combination of mometasone furoate and oxymetazoline for the treatment of adenoid hypertrophy concomitant with allergic rhinitis: A randomized controlled trial

Liu

Zhou

Zeng

et al. 2017

Sci Rep

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In the clinic, approximately 30% of children with adenoid hypertrophy (AH) concomitant with allergic rhinitis (AR) report poor responses to intranasal steroids. To determine whether the combination of mometasone furoate (MF) and oxymetazoline (OXY) is more effective than either agent alone, we performed a two-stage, parallel, randomized, double-blind, double-dummy, clinical trial with 240 AH children with concomitant perennial AR. During the first stage, all children were randomly assigned to the MF or control group for six weeks of treatment. During the second stage, the non-responders from stage one were randomly assigned to 4 groups for 8 weeks of treatment that involved receiving the following treatments: MF/OXY, MF/placebo, placebo/OXY, or placebo/placebo. During the first stage of treatment, 39% of the responders treated with MF achieved greater reductions in total and individual symptom scores than did those on placebo. During the second stage of treatment, the nasal congestion scores of the MF/OXY group significantly decreased. The adenoid/choana ratio of the MF/OXY-treated group decreased and the nasal volume increased significantly. Our results suggest that the combination of OXY and MF is effective and safe for the treatment of AH children with concomitant AR and has a rapid onset of action.

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“…However, this therapy is not evidence-based according to the literature and it may be considered to be inferior to the current surgical procedures; epipharyngoscopy, adenoidectomy and paracentesis, with placement of grommets. Surgical procedures for enlarged adenoids and tonsils have been shown to lead to a significant improvement in the quality of life and a reduction in long-term consequences such as conductive hearing loss and speech delay [4,5,7].…”

Section: Introductionmentioning

confidence: 99%

“…Occasionally, these patients also show partial adenoid facies and in rare cases even suffer with malocclusion. The hyperplastic adenoids are also associated with chronic inflammation of the upper respiratory tract and chronic bronchitis [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%