A double‐blind randomized clinical evaluation of enamel matrix derivative proteins for the treatment of proximal class‐II furcation involvements

Abstract

It may be concluded that the use of EMD in proximal furcations did not promote a superior reduction in PD or a gain in clinical and osseous attachment levels, but resulted in a higher rate of class-II to class-I furcation conversion.

Periodontal Regeneration – Furcation Defects: A Systematic Review From the AAP Regeneration Workshop

“…Thirty‐four articles were excluded after full‐text review (Table 3). 10‐12,16,30‐59 A final selection of 150 articles was made, of which six were systematic reviews, 2,60‐64 109 were clinical trials, 53,65‐172 27 were case series, 173‐199 and eight were case reports 200‐207 . No cohort studies were identified.…”

“…A total of 24 clinical trials 149‐172 and 13 case series 185‐197 were non‐classifiable, as defined in Materials and Methods (Tables 4 and 5). Of the 85 remaining clinical trials, 53,65‐148 eight reported outcomes after applying regenerative therapy on maxillary facial/interproximal Class II furcation defects, 76,87,92,100,105,140,148,208 68 on mandibular facial/lingual Class II furcation defects, 65‐68,70‐72,75,77,78,80‐85,87‐90,93‐99,101‐104,106,107,110‐112,114‐122,124‐139,141‐147 one on maxillary Class III furcation defects, 91 nine on mandibular Class III furcation defects, 69,73,74,77,86,108,109,113,123 and one on maxillary premolars presenting Class I and Class II furcation defects 79 . Of the 14 selected case series, two reported on the treatment of maxillary facial/interproximal Class II furcation defects, 177,180 11 on mandibular facial/lingual Class II furcation defects, 173‐176,178‐184 and two on mandibular Class III furcation defects 198,199 .…”

“…No study reported a sample size calculation. Five studies reported outcomes after a follow‐up period of 6 months, 76,87,92,148,208 one study had a duration of 9 months, 100 one study ran for 12 months, 105 and one article presented results after a 24‐month follow‐up period 140 . Two articles included the same patient population, so only the outcomes reported in the study with the longest follow‐up will be discussed 140 …”

Initial changes in alveolar bone volume for sham-operated and ovariectomized rats in ligature-induced experimental periodontitis

“…5). Once bone loss exceeds the furcation area, it is known that the regenerative potential of these teeth are much more limited with no guarantee that even with the use of the best available periodontal growth factors, these teeth maintain many uncertainties involving their ability to be restored [29][30][31]. Thus, the results from the present study demonstrate that there is a small window from which patients can change/modify their habits which may facilitate their necessary future periodontal regeneration further illustrating the need for medical practitioners to be aware of the patient's periodontal status and act upon the diseased state in a timely manner before furcation involvement is reached.…”

Use of cyanoacrylate as barrier in guided tissue regeneration in class II furcation defects

“…The furcation site is frequently affected by periodontal disease mainly due to its specific anatomy that complicates the effectiveness of calculus removal and decontamination of the area. [2] Factors such as root trunk length, furcation entrance, root separation, and root surface area can affect diagnosis, and consequently, the choice of the appropriate therapy for furcally involved molars. [3] Gottlow et al .…”