A double blind randomised trial of low power laser treatment in rheumatoid arthritis.

Heussler, Judith; Hinchey, G; Margiotta, Ezio; Quinn, Russell; Butler, Peter; Martín, Juan; Sturgess, A.

doi:10.1136/ard.52.10.703

Cited by 46 publications

(24 citation statements)

References 13 publications

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“…Table 1 summarizes some of excluded studies. Studies performed by Carvalho et al, 21 Gur et al (lower back), 22 and Heussler et al 23 were excluded because they had no placebo group. Studies by de Bie et al, 24 Ekim et al, 25 Rogvi-Hansen et al, 26 Aigner et al, 27 Yurtkuran et al, 28 and Shen et al 16 were excluded because there was no description of irradiation on the joint area or irradiation was performed only on the acupuncture points.…”

Section: Excluded Studiesmentioning

confidence: 99%

Meta-Analysis of Pain Relief Effects by Laser Irradiation on Joint Areas

Jang

Lee

2012

Photomedicine and Laser Surgery

104

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Background: Laser therapy has been proposed as a physical therapy for musculoskeletal disorders and has attained popularity because no side effects have been reported after treatment. However, its true effectiveness is still controversial because several clinical trials have reported the ineffectiveness of lasers in treating pain. Methods: In this systematic review, we investigate the clinical effectiveness of low-level laser therapy (LLLT) on joint pain. Clinical trials on joint pain satisfying the following conditions are included: the laser is irradiated on the joint area, the PEDro scale score is at least 5, and the effectiveness of the trial is measured using a visual analogue scale (VAS). To estimate the overall effectiveness of all included clinical trials, a mean weighted difference in change of pain on VAS was used. Results: MEDLINE is the main source of the literature search. After the literature search, 22 trials related to joint pain were selected. The average methodological quality score of the 22 trials consisting of 1014 patients was 7.96 on the PEDro scale; 11 trials reported positive effects and 11 trials reported negative effects. The mean weighted difference in change of pain on VAS was 13.96 mm (95% CI, 7.24-20.69) in favor of the active LLLT groups. When we only considered the clinical trials in which the energy dose was within the dose range suggested in the review by Bjordal et al. in 2003 and in World Association for Laser Therapy (WALT) dose recommendation, the mean effect sizes were 19.88 and 21.05 mm in favor of the true LLLT groups, respectively. Conclusions: The review shows that laser therapy on the joint reduces pain in patients. Moreover, when we restrict the energy doses of the laser therapy into the dose window suggested in the previous study, we can expect more reliable pain relief treatments.

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Section: Excluded Studiesmentioning

confidence: 99%

Meta-Analysis of Pain Relief Effects by Laser Irradiation on Joint Areas

Jang

Lee

2012

Photomedicine and Laser Surgery

104

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“…osteoarthritis, myofascial pain, and carpal tunnel syndrome. 3,[12][13][14][15] Nonetheless, consistent investigation has demonstrated that red and NIR low-intensity phototherapy can influence cells and tissues in a wavelength-specific, intensityspecific, energy dose-specific, and pulse frequency-specific manner. 10,11,[16][17][18][19] These effects are generally oxygen dependent and involve the generation of ROS.…”

Section: Introductionmentioning

confidence: 99%

Biophoton Detection and Low-Intensity Light Therapy: A Potential Clinical Partnership

Tafur

Wijk

et al. 2010

Photomedicine and Laser Surgery

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Low-intensity light therapy (LILT) is showing promise in the treatment of a wide variety of medical conditions. Concurrently, our knowledge of LILT mechanisms continues to expand. We are now aware of LILT's potential to induce cellular effects through, for example, accelerated ATP production and the mitigation of oxidative stress. In clinical use, however, it is often difficult to predict patient response to LILT. It appears that cellular reduction= oxidation (redox) state may play a central role in determining sensitivity to LILT and may help explain variability in patient responsiveness. In LILT, conditions associated with elevated reactive oxygen species (ROS) production, e.g. diabetic hyperglycemia, demonstrate increased sensitivity to LILT. Consequently, assessment of tissue redox conditions in vivo may prove helpful in identifying responsive tissues. A noninvasive redox measure may be useful in advancing investigation in LILT and may one day be helpful in better identifying responsive patients. The detection of biophotons, the production of which is associated with cellular redox state and the generation of ROS, represents just such an opportunity. In this review, we will present the case for pursuing further investigation into the potential clinical partnership between biophoton detection and LILT.

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“…This fact also should be considered when interpreting the actual findings, since a placebo group was not used as control, which is a limitation of the present study. Some authors 11,20,33,34 have reported good results for placebo control groups when compared to "real" electrotherapy. Feine and Lund 8 (1997), after a critical analysis of review articles about the efficacy of physical therapy for the control of chronic musculoskeletal pain, concluded that patients are helped during the period that they are being treated with most forms of physical therapy, however, most of these therapies have not been shown to be more efficacious than placebo.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the efficacy of low-level laser therapy (LLLT) and the microelectric neurostimulation (MENS) in the treatment of myogenic temporomandibular disorders: a randomized clinical trial

et al. 2005

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RESUMOwww.fob.usp.br/revista or www.scielo.br/jaos bjective: The aim of the present study was to evaluate the efficacy of low-level laser therapy (LLLT) and the microelectric neurostimulation (MENS) in the treatment of patients with temporomandibular disorders (TMD). Material and methods: A sample of 19 individuals presenting with signs and symptoms of myogenic TMD was randomly divided into two groups (I -LLLT and II -MENS). Therapy was done in 10 sessions, three times a week, for one month. Patients were evaluated by the Visual Analogue Scale (VAS), measurement of active range of motion (AROM) and muscle palpation, performed immediately before and 5 minutes after each therapeutic session by a blinded TMD specialist. The ANOVA for repeated measurements and Mann-Whitney tests were used for the statistical analysis. Results: The results showed an increase in maximum mouth opening and a decrease in tenderness to palpation for both groups. The VAS reduced for both groups, although more evident for the laser group (p<0.05). Conclusion: Authors concluded that both therapies were effective as part of the TMD treatment, and the cumulative effect may have been responsible for this fact. However, caution is recommended when judging the results due to the self-limiting aspect of musculoskeletal conditions such as TMD. Uniterms: Low-level laser therapy (LLLT); Temporomandibular joint disorders; Randomized controlled trials; Microelectric neurostimulation. bjetivo: Avaliar a efetividade do laser de baixa freqüência e do estímulo muscular microelétrico (MENS) no tratamento de pacientes com disfunções temporomandibulares (DTM). Material e Métodos: Uma amostra de 19 indivíduos com sinais e sintomas de DTM de origem muscular, foi dividida em dois grupos (I -laser e II -MENS). O tratamento consistiu de 10 sessões, três vezes por semana, durante um mês. Os critérios de avaliação dos pacientes foram: escala de análise visual (EAV), mensuração de abertura máxima bucal e palpação muscular, estes foram avaliados imediatamente antes e 5 minutos após cada sessão terapêutica, num estudo do tipo controlado. Para análise estatística, foram aplicados ANOVA para mensurações repetidas e Mann-Whitney. Resultados: Os resultados demonstraram aumento da abertura bucal máxima e diminuição na sensibilidade à palpação em ambos os grupos e, em relação à EAV, ambos os grupos demonstraram decréscimo, mas houve uma diferença estatisticamente significante entre os grupos, já que o grupo laser apresentou os melhores resultados p<0,05. Conclusão: Os autores concluíram que as duas terapias foram efetivas como parte do tratamento das DTM, e o efeito cumulativo podem ter sido responsável pela melhora. Porém sugere-se cautela quando se analisam os resultados devido ao aspecto autolimitante das condições músculo-esqueletais como as DTM. Unitermos: Terapia a laser de baixa intensidade; Transtornos da articulação temporomandibular; Ensaios controlados aleatórios. 2005; 13(3): 280-5 EVALUATION OF THE EFFICACY OF LOW-LEVEL LASER THERAPY (LLLT) AND THE MI...

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A double blind randomised trial of low power laser treatment in rheumatoid arthritis.

Cited by 46 publications

References 13 publications

Meta-Analysis of Pain Relief Effects by Laser Irradiation on Joint Areas

Meta-Analysis of Pain Relief Effects by Laser Irradiation on Joint Areas

Biophoton Detection and Low-Intensity Light Therapy: A Potential Clinical Partnership

Evaluation of the efficacy of low-level laser therapy (LLLT) and the microelectric neurostimulation (MENS) in the treatment of myogenic temporomandibular disorders: a randomized clinical trial

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