A Double-Blind Placebo Controlled Trial of Medroxyprogesterone Acetate and Cyproterone Acetate with Seven Pedophiles

Abstract

Seven of ten pedophiles in hospital completed a double-blind, placebo-controlled two-dose comparison of medroxyprogesterone acetate and cyproterone acetate. Sequential measures during the 28 week study were: patient self-reports, nurses' observations, phallometry, hormone levels and side-effects. The drugs, which performed equivalently, reduced sexual thoughts and fantasies, the frequency of early morning erections on awakening, the frequency and pleasure of masturbation, and level of sexual frustration. Penile responses were also reduced but to a lesser degree and were more variable. Serum testosterone FSH and LH all declined during drug administration, but by the end of the final placebo phase had essentially returned to (or exceeded) pre-drug values. Our experience suggests that only a minority of pedophiles are likely to accept libido-reducing drugs.

Protocols for the Use of Cyproterone, Medroxyprogesterone, and Leuprolide in the Treatment of Paraphilia

“…MPA and CPA have less dramatically and less consistently reduced testosterone levels (12,13) and have produced variable results when treating paraphilia (12).…”

Mirtazapine Treatment in a Subject with Autistic Disorder and Fetishism

“…2001;Albertini et al 2006). Furthermore, some reports on the psychopharmacological management of fetishism have mentioned the role of antidepressants such as clomipramine (Clayton 1993) and fluoxetine (Lorefice 1991;Kafka and Prentky 1992), antiandrogens, such as medroxyprogesterone acetate and cyproterone acetate (Cooper 1981;Cooper et al 1992), and some antiepileptics, such as topiramate (I-Shin Shiah et al 2006).…”

“…Although there are suggestions about educational and behavioral interventions (Koller 2000), medication treatment was preferable in this case due to the subject's inability to attend an educational program, the urgent need to abate this behavior, and the presence of other symptoms. A limited number of case reports show the efficacy of antiandrogen medication (Cooper 1981;Cooper et al 1992) and selective serotonin reuptake inhibitors (SSRIs) in the treatment of compulsive sexual behaviors. In particular, some case reports with mirtazapine stated the efficacy of this agent in abating hypersexual behaviors (Nguyen at al.…”

Review of Medical Reports on Pedophilia

“…149 In the same year, both cyproterone and medroxyprogesterone were reported to decease all sexual problems by decreasing the testosterone levels, but only the minority of pedophiles were likely to accept the libido-reducing drugs. 150 In 1993, one group concluded that there was no convincing evidence for success from drug treatment. 151 However, in the same year a more positive report was published of a decrease in recidivism, 152 and in 1995 a decrease in sex drive was claimed.…”