A double‐blind, placebo‐controlled trial of TRH in amyotrophic lateral sclerosis

Caroscio, James T.; Cohen, Jeffrey A.; Zawodniak, Janet; Takai, Valerie L.; Shapiro, Arthur M.; Blaustein, Steve; Mulvihill, Michael; Loucas, Spiro P.; Gudesblatt, Mark; Rube, David M.; Yahr, Melvin D.

doi:10.1212/wnl.36.2.141

Cited by 78 publications

(12 citation statements)

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“…Further, patients were divided into subgroups depending on the degree of bulbar involvement at the time of measurement. According to a bulbar involvement score [8]2 groups were differentiated, 1 with no or mild bulbar impairment (score 0–7), and the other with moderate to marked impairment (score 8–15). The disease duration (in months), the total score of the Norris scale [9], and upper motor neuron involvement [8]were correlated with gastric emptying half time (t½) and peak time (t peak ).…”

Section: Methodsmentioning

confidence: 99%

Noninvasive <sup>13</sup>C-Octanoic Acid Breath Test Shows Delayed Gastric Emptying in Patients with Amyotrophic Lateral Sclerosis

et al. 1999

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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of motor neurons. However, ALS has been recognized to also involve non-motor systems. Subclinical involvement of the autonomic system in ALS has been described. The recently developed ¹³C-octanoic acid breath test allows the noninvasive measurement of gastric emptying. With this new technique we investigated 18 patients with ALS and 14 healthy volunteers. None of the patients had diabetes mellitus or other disorders known to cause autonomic dysfunction. The participants received a solid standard test meal labeled with ¹³C-octanoic acid. Breath samples were taken at 15-min intervals for 5 h and were analyzed for ¹³CO₂ by isotope selective nondispersive infrared spectrometry. Gastric emptying peak time (t_peak) and emptying half time (t½) were determined. All healthy volunteers displayed normal gastric emptying with a mean emptying t½ of 138 ± 34 (range 68–172) min. Gastric emptying was delayed (t½ > 160 min) in 15 of 18 patients with ALS. Emptying t½ in ALS patients was 218 ± 48 (range 126–278) min (p < 0.001). These results are compatible with autonomic involvement in patients with ALS, causing delayed gastric emptying of solids and encouraging the theory that ALS is a multisystem disease rather than a disease of the motor neurons only.

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Section: Methodsmentioning

confidence: 99%

Noninvasive <sup>13</sup>C-Octanoic Acid Breath Test Shows Delayed Gastric Emptying in Patients with Amyotrophic Lateral Sclerosis

et al. 1999

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“…A muscle power rating by manual testing of the left biceps brachii muscle underlying the biopsied specimens of the skin was obtained by the following scale: 5 = normal strength; 4 = able to overcome moderate resistance; 3 = able to overcome gravity but not resistance; 2 = able to contract muscle with gravity eliminated; 1 = flicker of movement; 0 = no movement [14]. All ratings which were performed by the same examiner in individual patients were reproducible.…”

Section: Methodsmentioning

confidence: 99%

Serum Markers of Type I Collagen Synthesis and Degradation in Amyotrophic Lateral Sclerosis

Ono¹,

Imai²,

Shimizu³

et al. 2000

Eur Neurol

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Collagen abnormalities in the skin and spinal cord have been reported in amyotrophic lateral sclerosis (ALS) patients. Serum carboxyterminal propeptide of type I procollagen (PICP) and the carboxyterminal cross-linked telopeptide of type I collagen (ICTP) reflect type I collagen synthesis and degradation, respectively. However, there has been no study concerning PICP or ICTP in ALS. We studied collagen contents of the skin and measured serum levels of PICP and ICTP in patients with ALS and control subjects. Serum PICP levels were significantly lower in ALS patients than in controls. Serum ICTP levels were significantly higher in ALS patients than in controls, and there was an appreciable positive correlation between serum ICTP levels and the duration of illness in ALS patients. In ALS patients, the collagen content of the skin was significantly smaller than in controls and indicated a progressive decrease in relation to illness. In addition, there was a significant negative correlation between serum ICTP concentrations and the collagen content of the skin in ALS patients. These data suggest that increased ICTP levels and decreased serum PICP levels may reflect unique changes in the skin, with a predominance of degradation compared to the synthesis of type I collagen in ALS.

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“…Further, patients were divided into subgroups depending on the degree of bulbar involvement at the time of measurement. According to a bulbar involvement score [8] 2 groups were differentiated, 1 with no or mild bulbar impairment (score 0-7), and the other with moderate to marked impairment (score [8][9][10][11][12][13][14][15]. The disease duration (in months), the total score of the Norris scale [9], and upper motor neuron involvement [8] were correlated with gastric emptying half time (t½) and peak time (t peak ).…”

Section: Methodsmentioning

confidence: 99%

Noninvasive 13C-octanoic acid breath test shows delayed gastric emptying in patients with amyotrophic lateral sclerosis

Toepfer¹,

Riepl²,

Müller‐Felber³

et al. 1998

Gastroenterology

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ABC AbstractAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of motor neurons. However, ALS has been recognized to also involve non-motor systems. Subclinical involvement of the autonomic system in ALS has been described. The recently developed 13 C-octanoic acid breath test allows the noninvasive measurement of gastric emptying. With this new technique we investigated 18 patients with ALS and 14 healthy volunteers. None of the patients had diabetes mellitus or other disorders known to cause autonomic dysfunction. The participants received a solid standard test meal labeled with 13 C-octanoic acid. Breath samples were taken at 15-min intervals for 5 h and were analyzed for 13 CO 2 by isotope selective nondispersive infrared spectrometry. Gastric emptying peak time (t peak ) and emptying half time (t½) were determined. All healthy volunteers displayed normal gastric emptying with a mean emptying t½ of 138 B 34 (range 68-172) min. Gastric emptying was delayed (t½ 1 160 min) in 15 of 18 patients with ALS. Emptying t½ in ALS patients was 218 B 48 (range 126-278) min (p ! 0.001). These results are compatible with autonomic involvement in patients with ALS, causing delayed gastric emptying of solids and encouraging the theory that ALS is a multisystem disease rather than a disease of the motor neurons only.

show abstract

A double‐blind, placebo‐controlled trial of TRH in amyotrophic lateral sclerosis

Cited by 78 publications

References 1 publication

Noninvasive <sup>13</sup>C-Octanoic Acid Breath Test Shows Delayed Gastric Emptying in Patients with Amyotrophic Lateral Sclerosis

Noninvasive <sup>13</sup>C-Octanoic Acid Breath Test Shows Delayed Gastric Emptying in Patients with Amyotrophic Lateral Sclerosis

Serum Markers of Type I Collagen Synthesis and Degradation in Amyotrophic Lateral Sclerosis

Noninvasive 13C-octanoic acid breath test shows delayed gastric emptying in patients with amyotrophic lateral sclerosis

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