A double‐blind placebo‐controlled trial of azithromycin as an adjunct to non‐surgical treatment of periodontitis in adults: clinical results

Abstract

Azithromycin may be a useful adjunct in the treatment of adult periodontitis, particularly where deep pockets are present.

Microbiological and Clinical Effects of Sitafloxacin and Azithromycin in Periodontitis Patients Receiving Supportive Periodontal Therapy

“…A number of studies have supported the clinical and microbiological advantages of systemically administered AZM as an adjunct to scaling and root planing (16)(17)(18)(19)(20). The use of AZM in periodontal treatment has become popular in Japan (21) instead of metronidazole (22) and clindamycin (23), both of which are commonly used for periodontal therapy in the United States and Europe, but are not approved in Japan due to government regulations.…”

Clinical and Metabolic changes after the Non- surgical Periodontal Therapy in patients with Type-2 Diabetes Mellitus with Chronic periodontitis with or without the Systemic administration of Azithromycin - A Randomized Controlled Clinical Trial

“…The present study there was significant improvement in PI, GI, PD and HbA1cin both the groups but there was significant improvement in group II when compared to group I. In a randomized double-blind placebocontrolled parallel-designed studies by Emingil et al 10 Gomi et al 11 , Oteo et al 12 , Smith et al 13 …”

When and How to use Antibiotics in Periodontal Treatment?

“…Bugüne kadar yapılan araştırmalarda, mekanik tedavinin farklı aşamalarında ek antibiyotik kullanımı değerlendirilmiştir. 21,22,23,24 Bu konuda görüş ayrılıkları bulunmakla birlikte, biyofilm tabakasının mekanik tedavi ile parçalanması esasına dayanarak, mekanik tedavinin bittiği seansta antibiyotik tedavisine başlamak en uygun zamanlama olarak kabul edilmektedir. 24 Bu aşamada mikroorganizma sayısı azaltılmış, biyofilm tabakasının organizasyonu tüm diş bölgelerinde bozulmuş ve uzaklaştırılmış olacağı için ek olarak uygulanan antibiyotik daha fazla etki gösterebilir.…”