A Double-Blind Placebo-controlled Trial of Ursodeoxycholic Acid in the Prevention of Gallstones during Weight Loss after Vertical Banded Gastroplasty

Williams, C. N.; Gowan, R; Perey, Bernard

doi:10.1381/096089293765559278

Cited by 44 publications

(29 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The risk is at the maximum level during rapid weight loss and around 24 months, and decreases to a minimum once the weight has stabilized (22). Our results were also consistent with the literature, gallstones were mainly identified within the first 24 months.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

The evaluation of gallstone formation in patients undergoing Roux-en -Y gastric bypass due to morbid obesity

Karadeniz¹,

Görgün²,

Kara³

2014

UCD

View full text Add to dashboard Cite

Objective: This study aimed to evaluate gallstone formation, prophylactic and selective cholecystectomy and the effectiveness of ursodeoxycholic acid treatment following laparoscopic Roux-en -Y gastric bypass (LRYGB) in morbid obese patients. Results: Fifty-three (88.3%) patients were female and seven (11.7%) were male. Eight of the 60 patients (13.3%) had previously undergone cholecystectomy. Six patients (11.5%) underwent cholecystectomy in addition to LRYGB due to preoperatively detected gallstones by ultrasonography. The remaining 46 patients were followed up for a mean duration of 28.57 months (5-56 months). In 10 (21.7%) of these patients, gallstones were detected and five patients with symptomatic gallstones underwent cholecystectomy. Patients who did and did not develop gallstones after LRYGB did not show a significant difference regarding age, gender and the new body mass index (BMI). Three patients were started on ursodeoxycholic acid and the treatment was continued for six months. Gallstones were not detected in these patients. Conclusion:In light of these data, since only a very small portion of patients develops symptomatic gallstones after LRYGB, we recommend cholecystectomy in patients with symptomatic gallstones or the use of ursodeoxycholic acid rather than a prophylactic approach. Prospective randomized controlled studies in larger series are required to support these results.

show abstract

Section: Discussionsupporting

confidence: 92%

“…A meta-analysis focusing on the side effects of UDCA treatment after bariatric surgery has not been published so far. However, it is stated that mild to moderate side effects are observed in most of the patients who use UDCA (22)(23)(24). UDCA was applied in the last three patients after LRYGB in our study and none developed gallstones.…”

Section: Discussionmentioning

confidence: 53%

The evaluation of gallstone formation in patients undergoing Roux-en -Y gastric bypass due to morbid obesity

Karadeniz¹,

Görgün²,

Kara³

2014

UCD

View full text Add to dashboard Cite

show abstract

“…The risk factors for gallstone formation include diminished bile acid and phospholipids secretions, high biliary cholesterol and nucleating factor secretions [6], increased presence of prostaglandins and arachidonic acid [3], and gallbladder stasis. All these act in various combinations to promote gallstone formation.…”

Section: Discussionmentioning

confidence: 99%

“…No meta-analysis on the incidence of symptomatic gallstones could be performed, because only one study ( [1][2][3][4]6].…”

Section: Sensitivity Analysismentioning

confidence: 99%

Ursodeoxycholic Acid in the Prevention of Gallstone Formation after Bariatric Surgery: A Meta-analysis

et al. 2008

View full text Add to dashboard Cite

show abstract

“…qd to prevent cholelithiasis. 35 Subjects were allowed to eat ad libitum, and neither dietary nor exercise interventions were recommended.…”

Section: Interventionmentioning

confidence: 99%

Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults

et al. 2003

View full text Add to dashboard Cite

PURPOSE:Hyperinsulinemia is a common feature of many obesity syndromes. We investigated whether suppression of insulin secretion, without dietary or exercise intervention, could promote weight loss and alter food intake and preference in obese adults. METHODS: Suppression of insulin secretion was achieved using octreotide-LAR 40 mg IM q28d for 24 weeks in 44 severely obese adults (89% female, 39% minority). Oral glucose tolerance testing was performed before and after treatment, indices of b-cell activity (CIRgp), insulin sensitivity (CISI), and clearance (CP/I AUC) were computed, and leptin levels, 3-day food records and carbohydrate-craving measurements were obtained. DEXA evaluations were performed pre-and post-therapy in an evaluable subgroup. RESULTS: For the entire cohort, significant insulin suppression was achieved with simultaneous improvements in insulin sensitivity, weight loss, and body mass index (BMI). Leptin, fat mass, total caloric intake, and carbohydrate craving significantly decreased. When grouped by BMI response, high responders (HR; DBMIoÀ3 kg/m 2 ) and low responders (LR; DBMI between À3 and À0.5) exhibited higher suppression of CIRgp and IAUC than nonresponders (NR; DBMI > À0.5). CISI improved and significant declines in leptin and fat mass occurred only in HR and LR. Conversely, both leptin and fat mass increased in NR. Carbohydrate intake was markedly suppressed in HR only, while carbohydrate-craving scores decreased in HR and LR. For the entire cohort, DBMI correlated with DCISI, Dfat mass, and Dleptin. DFat mass also correlated with DIAUC and DCISI. CONCLUSIONS: In a subcohort of obese adults, suppression of insulin secretion was associated with loss of body weight and fat mass and with concomitant modulation of caloric intake and macronutrient preference.

show abstract

A Double-Blind Placebo-controlled Trial of Ursodeoxycholic Acid in the Prevention of Gallstones during Weight Loss after Vertical Banded Gastroplasty

Cited by 44 publications

References 8 publications

The evaluation of gallstone formation in patients undergoing Roux-en -Y gastric bypass due to morbid obesity

The evaluation of gallstone formation in patients undergoing Roux-en -Y gastric bypass due to morbid obesity

Ursodeoxycholic Acid in the Prevention of Gallstone Formation after Bariatric Surgery: A Meta-analysis

Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults

Contact Info

Product

Resources

About