A Double-blind, Placebo-controlled Trial of Transdermal Fentanyl after Abdominal Hysterectomy Analgesic, Respiratory, and Pharmacokinetic Effects

Six- versus 12-h conversion method from intravenous to transdermal fentanyl in chronic cancer pain: a randomized study

“…The construction of the fentanyl patch, that allowed the continuous transdermal application of a potent opioid, has provided new options, and its benefit, for example, for patients unable to take oral medications is evident. The therapeutic window of transdermal fentanyl varies widely between patients, serum fentanyl concentrations increase gradually following initial application, and peak serum concentrations of fentanyl generally occurred between 12 and 48 h after initial application, all of which explain the difficulties of adjusting the conversion [5][6][7]. A few reports are available on the conversion from intravenous fentanyl to transdermal fentanyl [8][9][10].…”

Efficacy and Safety of Transdermal Fentanyl in the Control of Postoperative Pain After Photorefractive Keratectomy

“…Previous studies have administered premedication with TDF 1-2 h before surgery; this resulted in mostly favorable outcomes. 10,[29][30][31][32][33] In our study, TDF was administered 2 h preoperatively. However, our results suggest the need for further evaluation of earlier premedication with TDF and/or additional adjuvant medication to efficiently cope with early postoperative pain after PRK.…”

Multicenter clinical study for evaluation of efficacy and safety of transdermal fentanyl matrix patch in treatment of moderate to severe cancer pain in 474 Chinese cancer patients

“…The most frequent AEs during TDF treatment were constipation, nausea, vomiting, stomach discomfort, dizziness, drowsiness and dysuria, most of which involved the gastrointestinal system and central nervous system. [33][34][35] . Consequently, patient with hypoventilation should be carefully observed and their respiratory rate must be monitored until respiratory status has stabilized.…”