A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis

Gabrielian, E.; Shukarian, A.K.; Goukasova, G.I.; Chandanian, G.L.; Panossian, Alexander; Wikman, G.; Wagner, Hildebert

doi:10.1078/094471102321616391

Cited by 111 publications

(78 citation statements)

References 7 publications

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“…Moreover, Andrographis paniculata accelerated recuperation of common cold patients with symptoms including nasal discharge, nasal stuffiness, sore throat, earache, cough, fever, headache, and malaise. 5,75,76) The mechanism of action of Andrographis paniculata in treatment of URI remains unclear to date. The apparent effectiveness of the plant may be based either on its anti-inflammatory properties or on its immunomodulatory properties.…”

Section: Respiratory System Benefitsmentioning

confidence: 99%

Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide

Jarukamjorn

Nemoto

2008

JOURNAL OF HEALTH SCIENCE

197

111

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Nowadays, research on medicinal plants has attracted a lot of attention globally. A number of evidence has been accumulated to demonstrate promising potential of medicinal plants used in various traditional, complementary, and alternative systems. In recent years, a medicinal plant, Andrographis paniculata, and its major active phytochemicals have been extensively studied for several pharmacological activities. To understand the mechanism of action, researches have to be carried out at molecular levels. The present review aims at compiling consequential compendium of pharmacological benefits of health on this plant and its major diterpenoid constituent andrographolide that have been tested in various experimental models using modern scientific methodologies.

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Section: Respiratory System Benefitsmentioning

confidence: 99%

Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide

Jarukamjorn

Nemoto

2008

JOURNAL OF HEALTH SCIENCE

197

111

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“…Whole-plant extracts have been used as a popular remedy for the treatment of various disorders and recently shown to have antitumoral (Rajagopal et al, 2003), anti-inflammatory (Gabrielian et al, 2002), and antiviral properties (Calabrese et al, 2000). Diterpenoid chemicals are the primary constituents present in the extracts of A. paniculata, where andrographolide, a bicyclic diterpenoid lactone, is the major constituent.…”

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confidence: 99%

Andrographolide Interferes with T Cell Activation and Reduces Experimental Autoimmune Encephalomyelitis in the Mouse

Iruretagoyena

Tobar²,

González³

et al. 2004

J Pharmacol Exp Ther

163

108

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Andrographolide is a bicyclic diterpenoid lactone derived from extracts of Andrographis paniculata, a plant indigenous to South Asian countries that shows anti-inflammatory properties. The molecular and cellular bases for this immunomodulatory capacity remain unknown. Here, we show that andrographolide is able to down-modulate both humoral and cellular adaptive immune responses. In vitro, this molecule was able to interfere with T cell proliferation and cytokine release in response to allogenic stimulation. These results were consistent with the observation that T cell activation by dendritic cells (DCs) was completely abolished by exposing DCs to andrographolide during antigen pulse. This molecule was able to interfere with maturation of DCs and with their ability to present antigens to T cells. Furthermore, in vivo immune responses such as antibody response to a thymus-dependent antigen and delayed-type hypersensitivity were drastically diminished in mice by andrographolide treatment. Finally, the ability of andrographolide to inhibit T cell activation was applied to interfere with the onset of experimental autoimmune encephalomyelitis (EAE), an inflammatory demyelinating disease of the central nervous system that is primarily mediated by CD4 ϩ T cells and serves as an animal model for human multiple sclerosis. Treatment with andrographolide was able to significantly reduce EAE symptoms in mice by inhibiting T cell and antibody responses directed to myelin antigens. Our data suggest that andrographolide is able to efficiently block T cell activation in vitro, as well as in vivo, a feature that could be useful for interfering with detrimental T cell responses.

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“…The dissolution studies were carried out in two different dissolution media such as acidic buffer of pH 1.2 and phosphate buffer of pH 6.8. Samples were withdrawn at 5,10,15, 30, 45, 60, 90 and 120 min and replaced with fresh dissolution media. After filtration through Whatman filter paper, required quantity of methanol was added and concentration of andrographolide was determined UV-spectrophotometrically at 224 nm.…”

Section: In-vitro Drug Release Studies 22mentioning

confidence: 99%

Formulation and Evaluation of Solid Dispersion Tablet of Andrographis paniculata Extract

Nitave¹,

Chougule²,

Koumaravelou³

2018

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Objective: To enhance solubility of ethanolic extract of Andrographis paniculata by solid dispersion technique and to perform formulation and evaluation of solid dispersion tablet. Materials and Methods: Solid dispersion of Andrographis paniculata extract has been prepared by solvent evaporation technique using soluplus and PEG 6000. Prepared solid dispersions have been evaluated for various micromeritic properties. The tablets of solid dispersion were prepared by direct compression technique and were evaluated for various physical tests and in-vitro dissolution study. Results: The study showed that prepared solid dispersion has good flow property and compressibility. The solubility of extract was found to be more from solid dispersion prepared by using soluplus than that of prepared by using PEG 6000. The rate of drug release was found to be higher in acidic buffer at pH 1.2 as compared to that of in phosphate buffer at pH 6.8. Conclusion: The study concludes that the solid dispersion tablet of ethanolic extract of Andrographis paniculata can be effectively prepared using soluplus by solvent evaporation technique so as to increase solubility, dissolution and hence oral bioavailability of andrographolide. enhanced its importance in the arena of medicinal plants. [7][8][9][10][11][12] Authors have already done phytochemical investigation, analgesic and antipyretic activities of ethanolic extract of Andrographis paniculata. The findings of study indicated that ethanolic extract of Andrographis paniculata have significant analgesic and antipyretic activity. 13 The extracted andrographolide has poor water solubility hence need to enhance solubility so as to increase the absorption and oral bioavailability. Hence the objective of present study is to enhance solubility of ethanolic extract of Andrographis paniculata by solid dispersion technique and to perform formulation and evaluation of solid dispersion tablet. MATERIALS AND METHODS MaterialsEthanolic extract of Andrographis paniculata aerial part was prepared and used. Lactose and starch were procured from Loba Chemie Pvt. Ltd., Mumbai. Soluplus was procured from BASF, Mumbai. PEG 6000 was obtained from Merck India Ltd., Mumbai. All other chemicals used were of analytical grade. Methods Preparation of Solid dispersion of Andrographis paniculata extracts using solvent evaporation techniqueSolid dispersions of Andrographis paniculata extract and polymer such as soluplus and PEG-6000 were prepared by solvent evaporation method. The ratio of Andrographis paniculata extract (equivalent to 50 mg of andrographolide) to polymer was taken as 1:1, 1:2 and 1:3. Composition of each ingredient is shown in Table 1. The Andrographis paniculata extract and polymer were separately dissolved in sufficient quantity of methanol. The clear solutions of extract and polymer were mixed and then the solvent was evaporated in water bath at 50°C till dryness. The dried sample of dispersion was kept in desiccator until further study. To this dried dispersion required quantity of micr...

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A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis

Cited by 111 publications

References 7 publications

Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide

Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide

Andrographolide Interferes with T Cell Activation and Reduces Experimental Autoimmune Encephalomyelitis in the Mouse

Formulation and Evaluation of Solid Dispersion Tablet of Andrographis paniculata Extract

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