A Double‐Blind Placebo‐Controlled Pilot Study of Sublingual Feverfew and Ginger (LipiGesic<sup>TM</sup>M) in the Treatment of Migraine

Cady, Roger; Goldstein, Jerome; Nett, Robert; Mitchell, Russell; Beach, M.E.; Browning, Rebecca

doi:10.1111/j.1526-4610.2011.01910.x

Cited by 65 publications

(30 citation statements)

References 18 publications

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“…The underlying pharmacokinetic and/or pharmacodynamic mechanism responsible for the neuronal defunctionalization of TRPA1-expressing neurons by parthenolide remains to be elucidated. Nevertheless, this novel property of parthenolide may add up to previously described anti-inflammatory actions of the compound [18, 36, 38] to account for the ability of chronically or acutely administered feverfew to prevent migraine attacks [12–14]. …”

Section: Discussionmentioning

confidence: 99%

“…Positive well-powered, randomized clinical trials [14, 37] have led to the recommendation of MIG-99, a relatively stable extract manufactured with supercritical CO 2 from feverfew, for migraine prevention with a level B of evidence [22]. More recently, two similar sublingually administered products containing feverfew and ginger have been successfully tested as an acute treatment for migraine attacks [12, 13]. However, the underlying mechanism of the antimigraine action of feverfew remains unknown.…”

Section: Introductionmentioning

confidence: 99%

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Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel

Materazzi

Benemei²,

Fusi

et al. 2013

Pain

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While feverfew has been used for centuries to treat pain and headaches and is recommended for migraine treatment, the mechanism for its protective action remains unknown. Migraine is triggered by calcitonin gene-related peptide (CGRP) release from trigeminal neurons. Peptidergic sensory neurons, express a series of transient receptor potential (TRP) channels, including the ankyrin 1 (TRPA1) channel. Recent findings have identified agents either inhaled from the environment or produced endogenously, which are known to trigger migraine or cluster headache attacks, as TRPA1 simulants. A major constituent of feverfew, parthenolide, may interact with TRPA1 nucleophilic sites, suggesting that feverfew antimigraine effect derives from its ability to target TRPA1. We found that parthenolide stimulates recombinant (transfected cells) or natively expressed (rat/mouse trigeminal neurons) TRPA1, where it, however, behaves as a partial agonist. Furthermore, in rodents, after initial stimulation, parthenolide desensitizes the TRPA1 channel, and renders peptidergic, TRPA1-expressing nerve terminals unresponsive to any stimulus. This effect of parthenolide abrogates nociceptive responses evoked by stimulation of peripheral trigeminal endings. TRPA1 targeting and neuronal desensitization by parthenolide inhibits CGRP release from trigeminal neurons and CGRP-mediated meningeal vasodilatation, evoked by either TRPA1 agonists or other unspecific stimuli. TRPA1 partial agonism, together with desensitization and nociceptor defunctionalization, ultimately resulting in inhibition of CGRP release within the trigeminovascular system, may contribute to the antimigraine effect of parthenolide.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel

Materazzi

Benemei²,

Fusi

et al. 2013

Pain

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“…Cady et al [40] reported that ginger administration caused a significant deceleration in severity of headache in patients with migraine [40]. One of the symptoms of PMS is incidence of headache and exacerbation of migraine.…”

Section: Discussionmentioning

confidence: 99%

Effect of Treatment with Ginger on the Severity of Premenstrual Syndrome Symptoms

Khayat

Kheirkhah

Moghadam

et al. 2014

ISRN Obstetrics and Gynecology

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Premenstrual syndrome (PMS) is a common disorder. Although the etiology of PMS is not clear, to relieve from this syndrome different methods are recommended. One of them is use of medicinal herbs. This study was carried out to evaluate effects of ginger on severity of symptoms of PMS. This study was a clinical trial, double-blinded work, and participants were randomly allocated to intervention (n = 35) and control (n = 35) groups. To determine persons suffering from PMS, participants completed daily record scale questionnaire for two consecutive cycles. After identification, each participant received two ginger capsules daily from seven days before menstruation to three days after menstruation for three cycles and they recorded severity of the symptoms by daily record scale questionnaire. Data before intervention were compared with date 1, 2, and 3 months after intervention. Before intervention, there were no significant differences between the mean scores of PMS symptoms in the two groups, but after 1, 2, and 3 months of treatment, there was a significant difference between the two groups (P < 0.0001). Based on the results of this study, maybe ginger is effective in the reduction of severity of mood and physical and behavioral symptoms of PMS and we suggest ginger as treatment for PMS.

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“…The combination, compared with placebo over 208 attacks treated at the onset of mild pain, resulted in greater pain reduction and pain relief at two hours (pain level feverfew-ginger 1.41 to 1.17 v control 1.67 to 1.70 (P<0.05); no pain feverfew-ginger 32.19% v control 15.79% (P<0.05)). 67 Several other botanicals have been studied for the treatment of headache, including in two RCTs reviewed. Lavender oil was inhaled for 15 minutes at the onset of headache symptoms for up to six consecutive headaches in 47 patients with migraine while symptoms were monitored at 30 minute intervals for two hours.…”

Section: Mind-bodymentioning

confidence: 99%

Complementary and integrative medicine in the management of headache

Millstine

Chen

Bauer

2017

BMJ

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Headaches, including primary headaches such as migraine and tension-type headache, are a common clinical problem. Complementary and integrative medicine (CIM), formerly known as complementary and alternative medicine (CAM), uses evidence informed modalities to assist in the health and healing of patients. CIM commonly includes the use of nutrition, movement practices, manual therapy, traditional Chinese medicine, and mind-body strategies. This review summarizes the literature on the use of CIM for primary headache and is based on five meta-analyses, seven systematic reviews, and 34 randomized controlled trials (RCTs). The overall quality of the evidence for CIM in headache management is generally low and occasionally moderate. Available evidence suggests that traditional Chinese medicine including acupuncture, massage, yoga, biofeedback, and meditation have a positive effect on migraine and tension headaches. Spinal manipulation, chiropractic care, some supplements and botanicals, diet alteration, and hydrotherapy may also be beneficial in migraine headache. CIM has not been studied or it is not effective for cluster headache. Further research is needed to determine the most effective role for CIM in patients with headache.

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A Double‐Blind Placebo‐Controlled Pilot Study of Sublingual Feverfew and Ginger (LipiGesic^TMM) in the Treatment of Migraine

Abstract: Sublingual feverfew/ginger appears safe and effective as a first-line abortive treatment for a population of migraineurs who frequently experience mild headache prior to the onset of moderate to severe headache.

Cited by 65 publications

References 18 publications

Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel

Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel

Effect of Treatment with Ginger on the Severity of Premenstrual Syndrome Symptoms

Complementary and integrative medicine in the management of headache

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A Double‐Blind Placebo‐Controlled Pilot Study of Sublingual Feverfew and Ginger (LipiGesicTMM) in the Treatment of Migraine

Abstract: Sublingual feverfew/ginger appears safe and effective as a first-line abortive treatment for a population of migraineurs who frequently experience mild headache prior to the onset of moderate to severe headache.

Cited by 65 publications

References 18 publications

Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel

Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel

Effect of Treatment with Ginger on the Severity of Premenstrual Syndrome Symptoms

Complementary and integrative medicine in the management of headache

Contact Info

Product

Resources

About

A Double‐Blind Placebo‐Controlled Pilot Study of Sublingual Feverfew and Ginger (LipiGesic^TMM) in the Treatment of Migraine