A double-blind controlled cross-over trial of cyproterone acetate in females with hidradenitis suppurativa

Abstract

In order to examine whether anti-androgen therapy was effective in hidradenitis suppurativa (HS), ethinyloestradiol 50 micrograms/cyproterone acetate 50 mg in a reverse sequential regimen was compared with ethinyloestradiol 50 micrograms/norgestrel 500 micrograms (Eugynon 50) in 24 female patients. Both treatments produced substantial improvement in disease activity. Seven patients cleared and have remained free of disease for 18 months, five patients improved, four remained unchanged, while two deteriorated. Cyproterone acetate was not clinically significantly more effective than E50, and both gave a similar reduction in free androgen index. Anti-androgen therapy appears to be beneficial in the treatment of hidradenitis suppurativa.

Recurrence after surgical treatment of hidradenitis suppurativa

“…Recurrent disease-Disease recurred locally at 21 sites in 19 patients, developing from three to 72 months (median 24 months) after operation in 15 patients after inguinoperineal surgery, in three after axillary excision, and in three after mammary excisions, giving recurrence rates of 37%, 3%, and 50%, respectively. There was no local recurrence after operation for perianal disease.…”

“…Anatomy and subversion: 150th anniversary of Georg Buchner's death J L CRIGHTON Karl Georg Buchner died of typhus in Zurich on 19 February 1837 in his 24th year. Like the friends in whose home he had been cared for, and like Schonlein, one of the physicians who attended him, he was a refugee from the political oppression prevailing in the German states ofthe post-Metternich era.…”

An Update on Medical Treatment Options for Hidradenitis Suppurativa

“…However, a doubleblind controlled trial comparing ethinyloestradiol 50 lg/cyproterone 50 mg with ethinyloestradiol 50 lg/ norgestrel 500 lg showed no difference between the two groups. However, of the 18 patients from both groups that completed the trial, 12 showed a good response, suggesting that both hormonal therapies can be effective in HS [131]. However, larger, well powered studies on the use of hormonal therapy in HS are lacking.…”

Promising long-term outcomes of the reused skin-graft technique for chronic gluteal hidradenitis suppurativa

“…Chronic lesions, on the other hand, can be treated in a number of ways, including antibiotics 3,4,17,18 , hormones 19 and biologics 20,21 . However, non-surgical approaches provide only temporary improvement and relief.…”