A double-blind comparison of topical therapy of chlamydial ocular infection (TRIC infection) with rifampicin or chlortetracycline.

Darougar, S; Viswalingam, N D; El-Sheikh, H.; Hunter, P A; Yearsley, P

doi:10.1136/bjo.65.8.549

Cited by 19 publications

(7 citation statements)

References 3 publications

(2 reference statements)

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“…This and previous studies indicated that one should not refrain from trying to establish an etiological diagnosis, even if topical treatment with either chloramphenicol or fusidic acid has been given previously (Stenberg et al 1989;). After local tetracycline and erythro-656 mycin therapy chlamydial diagnostic tests may remain positive which is generally in contrast to cases given oral therapy with these two drugs (Darougar et al 1981). As the nasopharynx is also often colonized both in neonatal and adult chlamydial conjunctivitis cases (Schachter et al 1975;Beem & Saxon 1977;Stenberg et al 1988), local treatment is likely to fail.…”

Section: Discussionmentioning

confidence: 99%

Chlamydial conjunctivitis in neonates and adults History, clinical findings and follow‐up

Stenberg

1990

Acta Ophthalmologica

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This study presents data from 73 neonatal and 60 adult patients with chlamydial conjunctivitis who were studied by culture, enzyme-linked immunosorbent assay (ELISA) and immunofluorescence (IF) tests. All patients had visited three or more doctors before the diagnosis was established. Fourteen of the adults had consulted an ophthalmological emergency unit complaining of a foreign body sensation in the eye. The symptoms started monocularly in all 133 cases, however, the fellow eye was affected after 2-7 days in 54 of the neonates and in 5-30 days in 20 of the adult patients. The duration of symptoms before the etiological diagnosis was established was 5-198 days (mean 24 and median 15 days) in the neonates and 7-120 (mean 29 and median 22 days) in the adults. The conjunctivitis was mild, moderate and severe in 7, 72 and 48 of the neonatal eyes, when the etiological diagnosis was established. The corresponding figures for severity of conjunctivitis in the adult group were 9, 57 and 14. Nasopharyngeal colonization occurred in 56 (77%) of the children and in 35 (58%) of the adults. In the adults, only two males complained of symptoms of genital infection. In 46 (77%) adults one or more of the chlamydial diagnostic tests performed on genital samples was positive for Chlamydia trachomatis. Forty-five of the neonates were treated with erythromycin 40-50 mg per kg body weight divided in four daily doses for 14 days, while 35 of the adults were given 250 mg x 4 x 14 of erythromycin.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Chlamydial conjunctivitis in neonates and adults History, clinical findings and follow‐up

Stenberg

1990

Acta Ophthalmologica

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“…Since the disease is multifocal, systemic antibiotic treatment is favored over topical antibiotics for adult and neonatal chlamydial keratoconjunctivitis [23]. In these disorders, topical antibiotic treatment has been proven ineffective when given alone [24].…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Azithromycinin Rabbit Lacrimal Glands and Conjunctiv a

Karcioglu

Ahmed²,

Raines³

et al. 1998

Ophthalmic Res

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Purpose and Background: To measure azithromycin levels in rabbit lacrimal and Harder glands, conjunctiva and plasma after a single oral dose of 20 mg/kg. Drug levels in lacrimal gland tissue are significant in trachoma because the gland may be involved in the disease process and it is the source of tears by which the drug is carried to the external eye. Methods: Lacrimal and Harder glands, conjunctiva and plasma were collected from New Zealand white female rabbits at 24, 48, 72, 96 and 144 h following a single oral dose of azithromycin (20 mg/kg). Azithromycin levels in tissue and plasma were measured using high-performance liquid chromatography (HPLC) electrochemical detection. Results: Azithromycin levels peaked within the first 24 h in all tissues and plasma assayed. The highest concentration was in the lacrimal gland (6.2 µg/g, SD ± 0.8), followed by Harder gland (4.4 µg/g, SD ± 0.8), conjunctiva (0.9 µg/g, SD ± 0.5) and plasma (0.06 µg/g, SD ± 0.03). These concentrations reached their lowest measured levels at 120 and 144 h. Conclusion: Azithromycin levels measured throughout the 144 h after dosing were consistently above the minimum inhibitory range (MIC) for Chlamydia trachomatis (0.03–0.25 µg/ml) in the lacrimal glands, while the conjunctiva maintained a concentration above the MIC for 96 h and stayed within MIC levels for 144 h.

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“…Nach einem Behandlungszeitraum von 6 bzw. 7 Wochen wurde eine Verbesserung der klinischen Symptome, aber keine Erregerelimination erzielt (18,19). Rifampicin kam bisher nicht in der Tiermedizin zum Einsatz.…”

Section: Figunclassified

Chlamydophila-felis-Infektion bei Katzen

Hartmann¹,

Hartmann²

2010

Tierarztl Prax Ausg K

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Zusammenfassung Chlamydophila felis ist ein bei Katzen weit verbreiteter Erreger, der bei bis zu 60% der Katzen mit Konjunktivitis oder Katzenschnupfen vorkommt. Die Verbreitung erfolgt nicht nur durch klinisch kranke Katzen; auch asymptomatische Träger scheiden den Erreger aus. Die Behandlung der Infektion ist insofern problematisch, als es sich häufig um Katzen handelt, die im engen Kontakt zu anderen infizierten Katzen leben, und somit die Gefahr einer permanenten Reinfektion besteht. Zudem müssen die verabreichten Antibiotika bestimmte Anforderungen erfüllen, wie z. B. eine gute intrazelluläre Wirksamkeit, da der Erreger obligat intrazellulär vorkommt. Mit diesem Übersichtsartikel sollen verschiedene Therapieschemata und Managementoptionen bei Katzen mit Katzenschnupfen beschrieben, verglichen und kritisch gegenübergestellt werden.

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A double-blind comparison of topical therapy of chlamydial ocular infection (TRIC infection) with rifampicin or chlortetracycline.

Cited by 19 publications

References 3 publications

Chlamydial conjunctivitis in neonates and adults History, clinical findings and follow‐up

Chlamydial conjunctivitis in neonates and adults History, clinical findings and follow‐up

Pharmacokinetics of Azithromycinin Rabbit Lacrimal Glands and Conjunctiv a

Chlamydophila-felis-Infektion bei Katzen

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