A Double-Blind Comparison of Ropivacaine, Bupivacaine, and Mepivacaine During Sciatic and Femoral Nerve Blockade

Fanelli, Guido; Casati, Andrea; Beccaria, Paolo; Aldegheri, Giorgio; Berti, Marco; Tarantino, Federica; Torri, G.

doi:10.1213/00000539-199809000-00019

Cited by 140 publications

(63 citation statements)

References 14 publications

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“…The present study showed that ropivacaine did not differ from bupivacaine with respect to duration of analgesia. This was in agreement with previous studies comparing the postoperative analgesic efficacy of ropivacaine and bupivacaine in different types of nerve block for knee and hand surgery [39][40][41].…”

Section: Discussionsupporting

confidence: 93%

Ropivacaine versus Bupivacaine in Postoperative Pain Control

Mansour¹

2012

J Biotechnol Biomaterial

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Objective: The aim of this study was to compare between 2 types of long acting anesthetics: bupivacaine 0.5% and ropivacaine 0.75%, in terms of their duration of anesthesia, duration of analgesia and their effect in controlling postoperative pain after surgical removal of impacted lower third molars. Material and Methods:This study was conducted on fifty subjects referred to the Oral Surgery Department, Faculty of Dentistry, Mansoura University, for surgical removal of impacted lower third molar. Subjects were randomly assigned prior to surgery into 2 nerve block injections; the first group (group A) for an inferior alveolar nerve block (IANB) using bupivacaine and the second group (group B) for an IANB using ropivacaine. In each group, the patient's age, sex, type of impaction, severity of impaction was recorded. Time from the start of surgery till removal of impacted molar was taken as duration of surgery. Patients were instructed not to take any analgesics until numbness of lip and tongue receded.The time from onset of anaesthesia to when numbness of the lip and tongue receded as assessed by pricking is taken as the duration of anaesthesia. The time from the start of numbness to when the subject first requested a dose of oral analgesic (NSAID) was taken as duration of analgesia. Pain was assessed preoperatively and postoperatively, then patients instructed to record the extent of their pain at 3, 6, 9, and 12 hours on the day of surgery (D1), on the second (D2) and third days (D3) postoperatively. Post-operative analgesic consumption, inability to sleep because of pain, degree of overall satisfaction with the anaesthetic efficacy and postoperative pain management were considered. Results:The median duration of anaesthesia for the 7.5 mg/ml concentration of ropivacaine was approximately 6 hours, and for bupivacaine 5 mg/ml was approximately 7 hours. Bupivacaine can provide analgesia for 10.3 hours while ropivacaine can provide analgesia during the first 9.6 hours which is the period of maximum pain after third molar surgery. Conclusion:As regards a comparison of the study drugs with respect to post-operative pain experience, analgesic need and consumption, bupivacaine and ropivacaine appear to have equivalent efficacy.

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Section: Discussionsupporting

confidence: 93%

Ropivacaine versus Bupivacaine in Postoperative Pain Control

Mansour¹

2012

J Biotechnol Biomaterial

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“…Duration of motor block in our study was comparable with studies by Conolly et al, 12 Fanelli G, 23 Laura Bertini et al, 20 Vaghadia et al, 19 Misiolek et al, 24 Tripathi et al 22 and Chandini M. Soni et al 18 and there was no statistically significant difference between two of the study drugs.…”

Section: Variablessupporting

confidence: 89%

A Prospective, Randomised, Double-Blind Comparative Clinical Study of 0.5% Bupivacaine and 0.75% Ropivacaine for Sciatic Nerve Block in Patients Undergoing Elective Below Knee Surgeries

Hegde¹,

Manjunath²

2016

jemds

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BACKGROUNDSciatic nerve block is a useful technique for unilateral lower limb surgeries. Bupivacaine is the most commonly used long acting amide local anaesthetic agent for peripheral nerve blockade. Ropivacaine, a newly introduced amide local anaesthetic is similar to Bupivacaine in structure, less potent than bupivacaine and lacks cardiotoxic potential of Bupivacaine. Hence, this study is taken up to compare the block characteristics of equipotent doses of Bupivacaine and Ropivacaine.

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“…With regard to the blocking effects of bupivacaine and ropivacaine on peripheral nerves, most studies have reported that the onset time and duration of blockade are comparable at similar doses [3,12,13,17]. However, Åker-man et al [1] administered comparable doses of bupivacaine or ropivacaine epidurally to guinea pigs and reported Fig.…”

Section: Discussionmentioning

confidence: 99%

Relative Nerve Blocking Properties of Bupivacaine and Ropivacaine in Dogs Undergoing Brachial Plexus Block Using a Nerve Stimulator

et al. 2009

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ABSTRACT. In the present study, the efficacy of a nerve stimulator in performing brachial plexus block (BPB) in dogs was investigated. The nerve blocking effects of bupivacaine and ropivacaine for BPB were also compared. Twelve beagles were allocated to groups based on the following treatments: conventional BPB with 0.5% bupivacaine (0.5% BupiM group) or BPB with 0.5% bupivacaine, 0.5% ropivacaine or 0.75% ropivacaine and a nerve stimulator (the 0.5% BupiS, 0.5% RopiS and 0.75% RopiS groups, respectively). After BPB, nerve blocking effects were assessed based on sensory blockade in several cutaneous areas and knuckling. The ratio of full block (blockade in all cutaneous areas) for 0.5% BupiM was 25%, and that for 0.5% BupiS was significantly higher, 75% (p<0.05). For the 0.5% BupiS, 0.5% RopiS and 0.75% RopiS groups, the average duration of full block was 387, 184 and 275 min, respectively, and the average duration of knuckling was 703, 460 and 421 min, respectively. The duration of full block and knuckling for the two ropivacaine groups was shorter compared with that of the 0.5% BupiS group. In conclusion, when using bupivacaine and ropivacaine for BPB in dogs, it is worth noting that there are differences in onset time and duration and that effective perioperative analgesia can be achieved depending on the intended use.KEY WORDS: brachial plexus block, bupivacaine, canine, nerve stimulator, ropivacaine.

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A Double-Blind Comparison of Ropivacaine, Bupivacaine, and Mepivacaine During Sciatic and Femoral Nerve Blockade

Cited by 140 publications

References 14 publications

Ropivacaine versus Bupivacaine in Postoperative Pain Control

Ropivacaine versus Bupivacaine in Postoperative Pain Control

A Prospective, Randomised, Double-Blind Comparative Clinical Study of 0.5% Bupivacaine and 0.75% Ropivacaine for Sciatic Nerve Block in Patients Undergoing Elective Below Knee Surgeries

Relative Nerve Blocking Properties of Bupivacaine and Ropivacaine in Dogs Undergoing Brachial Plexus Block Using a Nerve Stimulator

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