A Double-Blind Comparison of Naproxen with Indomethacin in Osteoarthritis

Cochrane, George M.

doi:10.3109/03009747309097105

Cited by 11 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only one pub lished study [1] has utilized DSM criteria for Organic Mood Syndrome or Substance-Induced Mood Disorder. [ 136] Carbamazepinc [ 137] Carbaryl [138] Choline [139] 13-m-retinoic acid therapy [140] Etretinate [141] Fluorouracil [142] Mefloquine [143,144] Metoclopramide [145,146] Metronidazole [147,148] Interferon-alpha [149][150][151][152] Isotretinoin [153][154][155] Lomefloxacin [ 156] Nonsteroidal anti-inflammatory medications [157,158] Ondansetron [ 159] Phenytoin [160] Physostigminc [161] Sumatriptan [162] Theophylline [163] Tretinoin [164] Vigabatrin [165] The avoidance of DSM diagnostic criteria by researchers may relate to the unusual nature of these specific sets of criteria, which depart from the DSM theme of nonre liance on clinical etiological judgements [2], The DSM-IV diagnostic criteria for Substance-Induced Mood Disorder rely heavily on clinical judgements about etiology.…”

Section: Introductionmentioning

confidence: 99%

Drug-Induced Depression

Patten

Love

1997

Psychother Psychosom

View full text Add to dashboard Cite

Background: Certain drugs may contribute to the etiology of depressive symptoms and depressive disorders. The objective of this review is to critically appraise the literature concerned with these potential etiological associations. Method: The review was based on papers uncovered in electronic literature searches using Medline, Psychlit and Psychological Abstracts. Statistical power calculations were used to assist in the interpretation of negative results. Results: A large number of publications were uncovered, but most of these were case reports. There were relatively few empirical studies. Corticosteroids, certain calcium channel blockers and digoxin have been associated with depression by replicated, well conducted studies. Psychostimulant withdrawal is also associated with prominent depressive symptoms. Preliminary evidence suggests that antihyperlipidemic agents, angiotensin converting enzyme inhibitors, sedative hypnotics, psychostimulants and certain hormonal agents may also cause depression. Despite an extensive literature, the potential association between β-blockers and depressive symptoms remains controversial. There is no substantial evidence that l-dopa or histamine-2-receptor blockers cause depression and the literature is relatively conclusive in determining that thiazide diuretics are not associated with depressive symptoms. Conclusions: A small, but growing, literature confirms that certain drug exposures can contribute to the biopsychosocial etiology of depressive symptoms and disorders. Current beliefs and diagnostic conventions classify drug-induced depression into a distinct category (Substance-Induced Mood Disorder): but this approach is not specifically supported by the existing literature.

show abstract

Section: Introductionmentioning

confidence: 99%

Drug-Induced Depression

Patten

Love

1997

Psychother Psychosom

View full text Add to dashboard Cite

show abstract

“…Clinical studies have shown it to be an effective, well tolerated drug for the treatment of rheumatoid arthritis (Helby-Peterson et al, 1973;Hill et al, 1974;Bowers et al, 1975;Huskisson et al, 1976). In addition, earlier studies have suggested that naproxen is also effective for the relief of the signs and symptoms of osteoarthrosis (Cochrane, 1973;Kageyama, 1973;Tanaka et al, 1976). Accordingly, this study was designed to further evaluate the efficacy and tolerance of nap-Accepted for publication July 5, 1977 Correspondence to Dr Carter Multz, Syntex Corporation, 3401 Hillview Avenue, Palo Alto, California 94304, USA roxen for the treatment of osteoarthrosis of the two commonly affected weight-bearing joints, the hip and knee.…”

mentioning

confidence: 99%

Naproxen in osteoarthrosis. Double-blind crossover trial.

Blechman¹,

Willkens²,

Boncaldo³

et al. 1978

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

SUMMARY In this double-blind crossover trial, naproxen (750 mg/day) was compared to placebo for the treatment of osteoarthrosis of the hip and knee. Patients were randomly assigned to treatment with either naproxen or placebo for 4 weeks and then to treatment with the alternate agent for a second 4-week period. 8 out of 9 objective and subjective measurements of drug efficacy clearly differentiated naproxen from placebo at highly significant levels (P=00001 to 0 0004). Patient daily check lists of osteoarthrotic symptoms also showed a statistically significant difference between naproxen and placebo therapy. Both physicians and patients, when asked to give a 'final drug preference', showed a significant preference for naproxen over placebo. In general, the incidence of side effects was low and approximately the same for both naproxen and placebo. Laboratory assessments showed little difference between groups. The trial showed naproxen to be an effective and well tolerated drug for the treatment of osteoarthrosis of the hip and knee.

show abstract

A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents

Pemberton

Strand

1979

Digest Dis Sci

View full text Add to dashboard Cite

Newer nonsteroidal antiinflammatory agents (NSAI's) such as ibuprofen, neproxen, fenoprofen, and tolmetin have broadened the therapeutic choice and increased the chances of providing optimum arthritis control, but require careful assessment of the possibilities for unwanted drug effects when long-term therapy is required. A review of the literature on the gastrointestinal effects of the promising newer NSAIs, as compared with the older agents, aspirin, indomethacin, and phenylbutazone, is presented, highlighting animal toxicology and human adverse reaction surveillance data and the evidence for various suggested pathophysiological mechanisms.

show abstract

A Double-Blind Comparison of Naproxen with Indomethacin in Osteoarthritis

Cited by 11 publications

References 0 publications

Drug-Induced Depression

Drug-Induced Depression

Naproxen in osteoarthrosis. Double-blind crossover trial.

A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents

Contact Info

Product

Resources

About