A double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy with health-related quality of life as an outcome measure

Gillham, R. A.; Kane, Kevın; Bryant‐Comstock, Lynda; Brodie, Martin J.

doi:10.1053/seiz.2000.0428

Cited by 89 publications

(45 citation statements)

References 7 publications

(10 reference statements)

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“…1C, D and Supplementary Fig. S1), an autophagy inducer that was approved by the FDA to treat epilepsy and bipolar disorder (18,22). Based upon these preliminary findings, we performed experiments by using various short-term exposure models; we maintained the understanding that measurement of reference compounds will need to be conducted in media preparations to validate consistency of doses, requiring the standardization and evaluation of such compounds for future longitudinal studies.…”

Section: Discussionmentioning

confidence: 99%

Airway Exposure to E-Cigarette Vapors Impairs Autophagy and Induces Aggresome Formation

Shivalingappa

Hole

Westphal

et al. 2016

Antioxidants & Redox Signaling

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Aims: Electronic cigarettes (e-cigarettes) are proposed to be a safer alternative to tobacco cigarettes. Hence, we evaluated if e-cigarette vapors (eCV) impair cellular proteostasis similar to cigarette smoke exposure. Results: First, we evaluated the impact of eCV exposure (2.5 or 7.5 mg) on Beas2b cells that showed significant increase in accumulation of total polyubiquitinated proteins (Ub, insoluble fractions) with time-dependent decrease in proteasomal activities from 1 h ( p < 0.05), 3 h ( p < 0.001) to 6 h ( p < 0.001) of eCV exposure compared to room air control. We verified that even minimal eCV exposure (1 h) induces valosin-containing protein (VCP; p < 0.001), sequestosome-1/p62 (aberrant autophagy marker; p < 0.05), and aggresome formation (total polyUb-accumulation; p < 0.001) using immunoblotting (IB), fluorescence microscopy, and immunoprecipitation (IP). The inhibition of protein synthesis by 6 h of cycloheximide (50 lg/ml) treatment significantly ( p < 0.01) alleviates eCV-induced (1 h) aggresome bodies. We also observed that eCV (1 h)-induced protein aggregation can activate oxidative stress, apoptosis (caspase-3/7), and senescence ( p < 0.01) compared to room air controls. We verified using an autophagy inducer carbamazepine (20 lM, 6 h) or cysteamine (250 lM; 6 h, antioxidant) that eCV-induced changes in oxidative stress, poly-ub-accumulation, proteasomal activity, autophagy, apoptosis, and/or senescence could be controlled by autophagy induction. We further confirmed the role of acute eCV exposure on autophagy impairment in murine lungs (C57BL/6 and CD1) by IB (Ub, p62, VCP) and IP (VCP, p62), similar to in-vitro experiments. Innovation: In this study, we report for the first time that eCV exposure induces proteostasis/autophagy impairment leading to oxidative stress, apoptosis, and senescence that can be ameliorated by an autophagy inducer. Conclusion: eCV-induced autophagy impairment and aggresome formation suggest their potential role in chronic obstructive pulmonary disease-emphysema pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Airway Exposure to E-Cigarette Vapors Impairs Autophagy and Induces Aggresome Formation

Shivalingappa

Hole

Westphal

et al. 2016

Antioxidants & Redox Signaling

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“…45 Previous randomised studies comparing different drugs for epilepsy have either focused on clinical outcomes only or included only limited assessments of QoL. For example, Gillham and colleagues examined QoL in a 48-week study comparing LTG and CBZ 46 using the SEALS (Side Effects and Life Satisfaction) inventory, a 38-item questionnaire covering five QoL domains: worry, temper, cognition, dysphoria and tiredness. Overall, SEALS scores in the LTG group decreased significantly from baseline, with improvement across all five domains; patients taking CBZ experienced more short-term side-effects (first 4 weeks of treatment).…”

Section: Assessment Of Qol Outcomesmentioning

confidence: 99%

A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial

Marson¹,

Appleton²,

Ga³

et al. 2007

Health Technol Assess

101

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HTAHealth Technology Assessment NHS R&D HTA Programme www.hta.ac.uk HTAHow to obtain copies of this and other HTA Programme reports. An electronic version of this publication, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (http://www.hta.ac.uk). A fully searchable CD-ROM is also available (see below).Printed copies of HTA monographs cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our Despatch Agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide. Declared competing interests of authors: AG Marson has received speaker fees and reimbursement for attending conferences from Jannsen Cilag, Glaxo SmithKline, Novartis, Pfizer and Sanofi Synthelabo and research funding from Pfizer. DW Chadwick has received consultancy fees, speaker fees and reimbursement for attending conferences from Jannsen Cilag, Glaxo SmithKline, Novartis, Pfizer and Sanofi Synthelabo. DF Smith has received speaker fees and reimbursement for attending conferences from Jannsen Cilag, Glaxo SmithKline, Novartis, Pfizer and Sanofi Synthelabo and research funding from Glaxo SmithKline. R Appleton has received consultancy fees, speaker fees and reimbursement for attending conferences from Jannsen Cilag, Glaxo SmithKline and Sanofi Synthelabo. GA Baker has received research funding, speaker fees and reimbursement for attending conferences from Jannsen Cilag, Glaxo SmithKline, Novartis, Pfizer and Sanofi Synthelabo. A Jacoby has received research funding from Sanofi Synthelabo, GSK and Janssen-Cilag and has acted as a research consultant to Johnson and Johnson Pharmaceuticals. Published October 2007This report shoul...

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“…One compared LTG with CBZ, 77 one with PHT, 75 two with VPA 122,126 and two with conventional therapy. 114,118 Three studies used monotherapy OXC.…”

Section: Quality Of Lifementioning

confidence: 99%

“…Three of the six LTG trials were in newly diagnosed patients with either partial or generalised seizure types. 75,77,118 Two trials included patients with either refractory partial or generalised seizures. 114,122 One trial included both refractory and newly diagnosed patients who experienced either partial or generalised seizure types.…”

Section: Quality Of Lifementioning

confidence: 99%

Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation

Wilby¹,

Kainth²,

Hawkins³

et al. 2005

Health Technol Assess

199

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTA NHS R&D HTA ProgrammeT he research findings from the NHS R&D Health Technology Assessment (HTA) Programme directly influence key decision-making bodies such as the National Institute for Clinical Excellence (NICE) and the National Screening Committee (NSC) who rely on HTA outputs to help raise standards of care. HTA findings also help to improve the quality of the service in the NHS indirectly in that they form a key component of the 'National Knowledge Service' that is being developed to improve the evidence of clinical practice throughout the NHS.The HTA Programme was set up in 1993. Its role is to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined to include all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care, rather than settings of care.The HTA programme commissions research only on topics where it has identified key gaps in the evidence needed by the NHS. Suggestions for topics are actively sought from people working in the NHS, the public...

show abstract

A double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy with health-related quality of life as an outcome measure

Cited by 89 publications

References 7 publications

Airway Exposure to E-Cigarette Vapors Impairs Autophagy and Induces Aggresome Formation

Airway Exposure to E-Cigarette Vapors Impairs Autophagy and Induces Aggresome Formation

A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial

Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation

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