A double-blind comparative study of soluble aspirin and diclofenac dispersible in the control of postextraction pain after removal of impacted third molars

Bailey, B.M.W.; Zaki, G.A.; Rotman, Helen; Woodwards, R.T.

doi:10.1016/s0901-5027(05)80645-9

Cited by 23 publications

(14 citation statements)

References 12 publications

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“…Based on clinical postoperative assessment, some surgeons have reported no significant difference in the rate of bone healing following administration of ibuprofen (48), aspirin, diclofenac (49) and flurbiprofen (50). Regarding these clinical observations, Godden (51) contested a previous recommendation by Stone and Richards (52) that more clinical trials would be required to confirm or refute the alleged harmful effects of NSAIDs on bone healing.…”

Section: Potential Risks and Benefits Of Prolonged Use Of Nsaids In Cmentioning

confidence: 99%

Prostaglandins and bone: potential risks and benefits related to the use of nonsteroidal anti-inflammatory drugs in clinical dentistry

et al. 2008

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In the skeleton, prostaglandins, mainly PGE 2 produced by osteoblasts under COX-2 stimulation, play either a stimulatory or an inhibitory role in bone metabolism, depending on the physiological or pathological conditions. The anabolic effect occurs largely in response to mechanical forces and in bone fracture healing, whereas PGE 2 -mediated resorption contributes significantly to bone loss in inflammatory diseases and in response to prolonged immobilization.

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Section: Potential Risks and Benefits Of Prolonged Use Of Nsaids In Cmentioning

confidence: 99%

Prostaglandins and bone: potential risks and benefits related to the use of nonsteroidal anti-inflammatory drugs in clinical dentistry

et al. 2008

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“…Monheim's local anaesthesia and pain control in dental practice, 7th edition 2. Zuniga JR, Phillips CL, Shugars D, Lyon JA, Peroutka SJ, Swarbrick J, Bon for good patient care [5]. Impaction of third molar teeth is a common disorder which often necessitates their removal [6].…”

Section: Discussionmentioning

confidence: 99%

A comparitive study of diclofenac transdermal patch against oral diclofenac for pain control following removal of mandibular impacted third molars

Bachalli

Nandakumar

Srinath

2009

J. Maxillofac. Oral Surg.

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Objective The objectives of this study was to evaluate subjectively the analgesic efficacy of Oral Diclofenac Sodium against Diclofenac Sodium Transdermal patch in the management of postoperative pain following surgical removal of impacted mandibular third molars. Materials and methods Twenty healthy subjects belonging to both the sexes in the age group of 18-40 years with bilateral mesioangular impactions of mandibular third molar teeth underwent surgical removal under local anaesthesia by administering an inferior alveolar nerve block on two different occasions with a minimum interval of 1 week in-between the procedures. The postoperative pain was recorded on visual analog scale, a verbal rating scale, a pain relief scale and a pain intensity scale. Readings were taken at 2 hours, 4 hours, 8 hours, 12 hours and 24 hours postoperatively, taking the time at which the surgery was completed as a reference. On the second and third days, the repeat medication was administered at that reference time and recordings taken at the same intervals for a total of 3 days. Patients received the study medication i.e. Diclofenac Sodium 100mg once a day for 3 days after performing surgery on one side and the same patients were given Diclofenac Sodium Transdermal Patch 100mg once a day for 3 days after performing surgery on the contralateral side. Results and observations Both the statistical analysis and clinical observation showed that on the first postoperative day diclofenac sodium administered orally has slightly more significant efficacy when compared to the drug administered transdermally. However, on the second and third postoperative days there was no statistical or clinical difference in the pain control by either route of administration. Conclusions The study concludes that transdermal diclofenac sodium can be used as an alternative form of pain control following removal of impacted mandibular third molars, however considering that the analgesic potency might be lesser in the immediate postoperative period, it might be prudent to use oral diclofenac sodium for immediate postoperative pain relief, following which transdermal route can be used for pain control.

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“…Not an original report of trials, and unable to ensure that participants (total of 75 treated with ibuprofen) were not in another included study Bailey 1993 No placebo control.…”

Section: Averbuch 2000mentioning

confidence: 99%

Single dose oral ibuprofen for acute postoperative pain in adults

Collins

Moore²,

McQuay³

et al. 1999

Cochrane Database of Systematic Reviews

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A double-blind comparative study of soluble aspirin and diclofenac dispersible in the control of postextraction pain after removal of impacted third molars

Cited by 23 publications

References 12 publications

Prostaglandins and bone: potential risks and benefits related to the use of nonsteroidal anti-inflammatory drugs in clinical dentistry

Prostaglandins and bone: potential risks and benefits related to the use of nonsteroidal anti-inflammatory drugs in clinical dentistry

A comparitive study of diclofenac transdermal patch against oral diclofenac for pain control following removal of mandibular impacted third molars

Single dose oral ibuprofen for acute postoperative pain in adults

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