A Dose-Response Study on the Effects of Purified Lycopene Supplementation on Biomarkers of Oxidative Stress

Devaraj, Sridevi; Mathur, Surekha; Basu, Arpita; Aung, Hnin Hnin; Vasu, Vihas T.; Meyers, Stuart A.; Jialal, Ishwarlal

doi:10.1080/07315724.2008.10719699

Cited by 119 publications

(114 citation statements)

References 38 publications

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“…Despite these increases, no significant changes in lipid profiles or levels of other biomarkers of lipid peroxidation were observed. Only the subjects receiving 30 mg of lycopene per day exhibited significant decreases in DNA oxidative damage and urinary 8-hydroxydeoxyguanosine levels 22 . Interestingly, carotenoid supplementation has recently been shown to have beneficial effects on semen quality in a bird model.…”

Section: Discussionmentioning

confidence: 99%

“…Devaraj et al 22 tested the effects of daily dietary supplementation with 6.5, 15 or 30 mg of purified lycopene over the course of 8 weeks on the blood lipid profile in a Legend: P* (before/after lycopene) comparisons between the two respective MPIR groups in relation to pregnancy P** (before/after lycopene) multiple comparisons between each group vs. FV group double-blind, randomized, placebo-controlled trial which included 77 healthy volunteers. The treatment increased the levels of lycopene in blood plasma compared to placebo.…”

Section: Discussionmentioning

confidence: 99%

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Lycopene improves the distorted ratio between AA/DHA in the seminal plasma of infertile males and increases the likelihood of successful pregnancy

Filipčíková

Oborná²,

Březinová³

et al. 2015

BIOMED PAP

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Aims. Male infertility has been associated with imbalance in the polyunsaturated fatty acids arachidonic acid/docosahexaenoic acid (AA/DHA) ratio. This study aimed to assess whether use of the potent antioxidant, lycopene, would affect this imbalance in seminal plasma and to test whether modulation of the AA/DHA ratio correlates with male fertility. Methods. The study included 44 males from infertile couples who were treated with lycopene for three months before scheduled IVF treatment. The control group was 13 fertile males who were also treated with lycopene for three months. AA and DHA levels were measured in seminal plasma before and after treatment. The outcome of IVF treatment after lycopene use in of males from infertile couples was recorded. Results. The subjects were subdivided into 21 normozoospermic males from couples with idiopathic infertility and 23 males with semen abnormalities. Prior to the treatment with lycopene, the AA/DHA ratios in both subgroups of patients were significantly higher than in fertile controls and improved following treatment with lycopene. Improvement was more marked in the normospermic males. Seven spontaneous pregnancies (16%) occurred before the scheduled IVF treatment and 15 couples (42%) achieved pregnancy after IVF. Conclusions. Three months of treatment with lycopene led to a significant improvement in the AA/DHA ratio in seminal plasma of males from infertile couples and facilitated the spontaneous as well as IVF conception.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lycopene improves the distorted ratio between AA/DHA in the seminal plasma of infertile males and increases the likelihood of successful pregnancy

Filipčíková

Oborná²,

Březinová³

et al. 2015

BIOMED PAP

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“…This is because reactive oxygen species (ROS)-induced DNA base damage leads to the formation of abasic sites during base-excision repair which are detectable in the alkaline Comet assay and MN and NPB in the CBMN Cyt assay are efficiently induced by ROS such as H 2 O 2 , superoxide, and activated neutrophils [Umegaki and Fenech, 2000;Dotan et al, 2004;Muth et al, 2004;Devaraj et al, 2008]. Furthermore, we felt that it was imEnvironmental and Molecular Mutagenesis.…”

Section: Discussionmentioning

confidence: 99%

“…Results were mean 6 SEM (>). NS, nonsignificant. portant to use any additional effort and resources to measure other biomarker of oxidative stress such as protein carbonyls and F2-isoprostanes because it is evident that measurement with DNA end-points alone is not sufficient to obtain the full spectrum of ROS-induced damage to the organism [Dotan et al, 2004;Muth et al, 2004;Devaraj et al, 2008]. We did not conduct the challenge assay with ROS because our in vitro studies with human peripheral blood lymphocytes with Se-met, the predominant organic form of selenium, covering both physiological and supraphysiological concentrations, showed no impact on ionizing radiation-induced DNA damage and chromosome aberrations measured using the Comet and the CBMN Cyt assay, respectively [Wu et al, in press].…”

Section: Discussionmentioning

confidence: 99%

Increased consumption of wheat biofortified with selenium does not modify biomarkers of cancer risk, oxidative stress, or immune function in healthy Australian males

Salisbury

Graham

et al. 2009

Environ and Mol Mutagen

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Increased intake of selenium (Se) may reduce the risk of degenerative diseases including cancer but excessive intake may be toxic. Wheat is a major source of dietary Se in humans. However, the effect of Se from wheat that is agronomically biofortified with Se on biomarkers of human health status is unknown. This study aimed to investigate whether improving Se status, by increased dietary intake of Se‐biofortified wheat, affects biomarkers of cancer risk, cardiovascular disease risk, oxidative stress, and immune function in healthy South Australian men. A 24‐week placebo‐controlled double‐blind intervention was performed in healthy older men (n = 62), with increased dose of Se intake every 8 weeks. Wheat was provided as 1, 2, and 3 puffed wheat biscuits, during weeks 1–8, 9–16, and 17–24, respectively. Blood was collected to measure a wide range of disease risk biomarkers. Consumption of Se‐biofortified wheat was found to increase plasma Se concentration from a baseline level of 122 to 192 μg/L following intake of three biscuits/day, which provided 267 μg Se. Platelet glutathione peroxidase, chromosome aberrations, and DNA damage in lymphocytes measured using the cytokinesis‐block micronucleus cytome assay and with the Comet assay, plasma F2‐isoprostanes, protein carbonyls, plasma C‐reactive protein, and leukocyte number were unaffected by the improved Se status. Improvement of Se status by consumption of Se‐biofortified wheat did not substantially modify the selected biomarkers of degenerative disease risk and health status in this apparently selenium‐replete cohort of healthy older men in South Australia. Environ. Mol. Mutagen. 2009. © 2009 Wiley‐Liss, Inc.

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“…Lycopene is an acyclic symmetric hydrocarbon, containing eleven conjugated and two unconjugated double bonds [12,13]. Because of its unique structure (high number of conjugated double bonds) lycopene indicates greater biological significance in human antioxidant defense system among the natural carotenoids [10].…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effect of Lycopene on Lipid Peroxidation and Certain Antioxidant Enzymes in Diabetic Patients

Singh¹,

Bs²

2012

J Diabetes Metab

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Objectives: To study the ameliorative properties of lycopene in diabetic patients by measuring oxidative stress biomarkers such as malondialdehyde (MDA), antioxidant enzymes like xanthine oxidase (XOD), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and low molecular weight antioxidant compound that is reduced glutathione (GSH) in diabetic patients. Materials and Methods:The subjects were divided into three groups: Group-1: Normal healthy subjects (Control); Group-2: Diabetic patients and Group-3: 4 mg lycopene ingested diabetic patients. The levels of MDA, XOD, SOD, GPx, GR and GSH were determined in blood samples in all the groups for evaluation of oxidantantioxidant status.Results: A significant (p<0.001) elevation in MDA and XOD levels while a significant (p<0.01) reduction in SOD, GPx, GR and GSH levels was observed in diabetic patients. Oral administration of lycopene (4 mg once daily for 3 months) to diabetic patients attenuated the oxidative stress by significantly (p<0.01) decreasing the levels of MDA and XOD. In addition, lycopene significantly (p<0.01) increased the SOD, GSH, GPx and GR levels in lycopene ingested diabetic patients. Conclusion:Aforementioned observations suggested that oxidative stress increased in diabetics while ingestion of lycopene (4 mg/day for 3 months) might alleviate oxidative stress in diabetic patients and warrants further investigations with large clinical trials.

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A Dose-Response Study on the Effects of Purified Lycopene Supplementation on Biomarkers of Oxidative Stress

Abstract: Thus, purified lycopene was bioavailable and was shown to decrease DNA oxidative damage and urinary 8-OHdG at the high dose.

Cited by 119 publications

References 38 publications

Lycopene improves the distorted ratio between AA/DHA in the seminal plasma of infertile males and increases the likelihood of successful pregnancy

Lycopene improves the distorted ratio between AA/DHA in the seminal plasma of infertile males and increases the likelihood of successful pregnancy

Increased consumption of wheat biofortified with selenium does not modify biomarkers of cancer risk, oxidative stress, or immune function in healthy Australian males

Ameliorative Effect of Lycopene on Lipid Peroxidation and Certain Antioxidant Enzymes in Diabetic Patients

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