A dose-response evaluation of spray-dried yeast cell wall supplementation of diets fed to adult dogs: Effects on nutrient digestibility, immune indices, and fecal microbial populations1

Middelbos, Ingmar S.; Godoy, María R C de; Fastinger, Nathan D.; Fahey, G. C.

doi:10.2527/jas.2007-0079

Cited by 80 publications

(71 citation statements)

References 38 publications

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“…In this study, leukocyte counts in peripheral blood were decreased in lactulosetreated calves and monocyte numbers were decreased in both treatment groups. A similar effect has been found when mannanoligosaccharides were fed to dogs (Middelbos et al, 2007). In addition, the expression of IL2RA -an activation marker on the surface of lymphocytes -tended to be lowered in the colon of lactulose-treated calves compared with the control.…”

Section: Discussionsupporting

confidence: 72%

“…Fleige et al (2009) found a similar lowering of its expression in the mesenteric lymph nodes of lactulose-treated calves. Middelbos et al (2007) suggested that a lowering of the infectious load in the intestine due to the feeding of mannan moieties may decrease the necessity of activated immune cells in the vicinity. This may also be reflected in peripheral blood.…”

Section: Discussionmentioning

confidence: 99%

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Effects of the prebiotics inulin and lactulose on intestinal immunology and hematology of preruminant calves

Masanetz

Preißinger

Meyer

et al. 2011

Animal

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Prebiotics are suggested as an alternative to antibiotics in animal rearing. Fermentable substances such as inulin or lactulose have been proposed to stimulate the immune system and health by modulation of the intestinal flora and its fermentation products. In this study, effects of inulin and lactulose on the intestinal health and hematology of calves have been investigated. Both prebiotics significantly decreased thrombocyte counts in peripheral blood. Only inulin was able to increase hemoglobin concentration and hematocrit. Total leukocyte count was decreased by lactulose while both prebiotics tended to lower monocyte proportions. mRNA expression of inflammation-related markers in the intestine was also affected by both prebiotics hinting at a decreased inflammatory status. This may be due to a possible decrease in intestinal pathogen load that remains to be verified. Only mRNA amounts of interleukin 8 were increased by lactulose in mesenteric lymph nodes. In the ileum, expression of a proliferation marker was increased by inulin while an apoptosis-related gene was increased by both prebiotics. The results of this study show a clear effect of prebiotics on certain parameters associated with animal health and performance that remain to be studied in detail in future investigations.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Effects of the prebiotics inulin and lactulose on intestinal immunology and hematology of preruminant calves

Masanetz

Preißinger

Meyer

et al. 2011

Animal

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“…The microbial population within the gut was determined by quantitative, real-time PCR based on a method as described by Middelbos et al (2007) with minor modifications. Briefly, genomic DNA was isolated from the ileum contents (stored at −80°C) using a DNA extraction kit (QIAamp DNA Stool Mini Kit, Qiagen, Valencia, CA; Faber et al, 2012) according to the manufacturer's instructions.…”

Section: Analysis Of Intestinal Microbiotamentioning

confidence: 99%

Feed supplementation with red seaweeds, Chondrus crispus and Sarcodiotheca gaudichaudii, affects performance, egg quality, and gut microbiota of layer hens

et al. 2014

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The aim of this study was to evaluate the effect of the inclusion of red seaweed supplementation to standard poultry diets on production performance, egg quality, intestinal histology, and cecal short-chain fatty acids in Lohmann Brown Classic laying hens. A total of 160 birds were randomly assigned to 8 treatment groups. Control hens were fed a basal layer diet; positive control hens were fed a diet containing 2% inulin; and 6 treatment groups were fed a diet containing one of the following; 0.5, 1, or 2% Chondrus crispus (CC0.5, CC1, and CC2, respectively) and one of the same 3 levels of Sarcodiotheca gaudichaudii (SG0.5, SG1, and SG2, respectively). Dietary supplementation had no significant effect on the feed intake, BW, egg production, fecal moisture content, and blood serum profile of the birds. The feed conversion ratio per gram of egg was significantly more efficient (P = 0.001) for CC2 and SG2 treatments. Moreover, SG1 supplementation increased egg yolk weight (P = 0.0035) and birds with CC1 supplementation had higher egg weight (P = 0.0006). The SG2 and CC2 groups had greater (P < 0.05) villus height and villus surface area compared with the control birds. Seaweed supplementation increased the abundance of beneficial bacteria [e.g., Bifidobacterium longum (4- to 14-fold), Streptococcus salivarius (4- to 15-fold)] and importantly reduced the prevalence of Clostridium perfringens in the gut of the chicken. Additionally, the concentrations of short-chain fatty acids, including acetic acid, propionic acid, n-butyric acid, and i-butyric acid, were significantly higher (P < 0.05) in CC and SG treatments than in the control. In conclusion, dietary supplementation using red seaweed inclusions can act as a potential prebiotic to improve performance, egg quality, and overall gut health in layer hens.

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“…For instance, Field et al (1999) reported that the fermentable fibres altered the canine gutassociated lymphoid tissue composition and activity, but no changes were noted in blood. It has been suggested that the full benefit of prebiotic supplementation may not be detectable unless the immune system is challenged during supplementation (Middelbos et al, 2007a). There is evidence that the feeding of FOS increased the mucosal dendritic cell function associated with immune system in patients with Crohn's disease (Lindsay et al, 2006).…”

Section: Microbial Counts and Serum Ig Concentrationsmentioning

confidence: 99%

Responses of feeding prebiotics on nutrient digestibility, faecal microbiota composition and short-chain fatty acid concentrations in dogs: a meta-analysis

Patra

2011

Animal

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The effects of prebiotics on digestibility, short-chain fatty acid (SCFA) concentrations and bacterial populations in the faeces and immunity in dogs were evaluated by meta-analyses. Overall, data from 15 published studies containing 65 different treatment means of 418 observations from different breeds of dogs were included in the data set. Feeding of prebiotics to dogs did not affect the nutrient intake (P . 0.10), nor did prebiotics change (P . 0.10) the digestibility of dry matter (DM) and fat. However, crude protein (CP) digestibility tended to decrease quadratically (P 5 0.06) with increasing dosages of prebiotics, although the degree of prediction was low (R 2 5 0.33). The concentration of total SCFA (P 5 0.08; R 2 5 0.90) tended to increase linearly, whereas concentration of acetate (R 2 5 0.25), propionate (R 2 5 0.88) and butyrate (R 2 5 0.85) increased quadratically with increasing dosage of prebiotics in the faeces of dogs. The numbers of beneficial bifidobacteria (P , 0.01; R 2 5 0.62) increased quadratically, but lactobacilli (P , 0.01; R 2 5 0.66) increased linearly with increasing supplementation of prebiotics. The changes in healthy bacterial numbers were affected by the interaction of initial bacterial numbers and dose of prebiotics; bacterial numbers increased relatively more when initial bacterial numbers were low. Dietary composition did not influence the response of prebiotics on lactobacilli and bifidobacterial numbers in this study. The numbers of pathogenic Clostridium perfringens and Escherichia coli were not affected by prebiotics. Prebiotics did not affect the serum immunoglobulin (Ig) concentrations such as IgG, IgA and IgM in dogs. Although prebiotics may tend to have an adverse effect on CP digestibility, prebiotics at doses up to 1.40% food intake (DM basis) might increase the beneficial bacterial populations and SCFA concentrations in the faeces of dogs. Thus, the feeding of prebiotics has a great prospective to improve the intestinal health of dogs.

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A dose-response evaluation of spray-dried yeast cell wall supplementation of diets fed to adult dogs: Effects on nutrient digestibility, immune indices, and fecal microbial populations1

Cited by 80 publications

References 38 publications

Effects of the prebiotics inulin and lactulose on intestinal immunology and hematology of preruminant calves

Effects of the prebiotics inulin and lactulose on intestinal immunology and hematology of preruminant calves

Feed supplementation with red seaweeds, Chondrus crispus and Sarcodiotheca gaudichaudii, affects performance, egg quality, and gut microbiota of layer hens

Responses of feeding prebiotics on nutrient digestibility, faecal microbiota composition and short-chain fatty acid concentrations in dogs: a meta-analysis

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